DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and Arhgef5

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_038964580.1 Gene:Arhgef5 / 140898 RGDID:620718 Length:1589 Species:Rattus norvegicus


Alignment Length:2069 Identity:387/2069 - (18%)
Similarity:646/2069 - (31%) Gaps:714/2069 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 DRENQNAVP------PQTPPLPPSYKQNQ------MNGDSTAAAGGGVSAPATPTTAN------- 184
            |.|...|:|      .|.|.|.|..::.|      .:|..:......|....:..|.|       
  Rat    16 DIEELGAIPEGIMRSSQIPALDPEAQEGQDPSYKWTDGHRSLMDQSKVLRDVSDHTPNSVAIFFK 80

  Fly   185 -NNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQES--TTPATTPS 246
             :::|...:..|:....: :.:|....|.|:..:|  |:.|..:.:|.|...||.  ..|:...|
  Rat    81 KDSSAMATSQEILLAEAR-DTADQQEAVTQSLQDR--LSTTVAAPELLGCAVQEEWLDIPSKLDS 142

  Fly   247 TPSLALPKNFQYLTLTVRKDSNGYGMKVSGDNPVF--VESVKPGGAAEIAGLVAGDMILR----- 304
            .....|......|||.|.|:............|.|  ...:.||...:..|  :|..:||     
  Rat   143 RVEAELQPELMSLTLAVSKEKEEEESSPDTSTPGFWPPSKIHPGETDQTEG--SGMELLRQGKQL 205

  Fly   305 -------------------------VNGHEVRLEKHPTV------VGLIKASTTVELAV---KRS 335
                                     ..|.||.:::..|:      .||:.....||...   |..
  Rat   206 QLEATQENRGQQGLLQPQEAQGLEEQEGQEVEIQEEGTLREDICFGGLLGEQKEVEEDFNDNKEE 270

  Fly   336 QKLTRPSSVSVVTP--STPILSG------------RDRTASITGPQPVDSIKR------REMETY 380
            ||..:..|..::..  .:..|||            .:|...:.|.:  ||.:.      ||:|..
  Rat   271 QKQEQIQSYMLLGGQWESEGLSGELEGLNYNERSQEERERRVCGQR--DSKEEGQDQELREVEER 333

  Fly   381 KIQTL---QKMLEQEKLNLERLKSDQNNPSYKLSEANIRKL-----REQLHQVGAEDA--PTVKL 435
            ::.|.   .:|||:...|:.|.:.|.:.....:...:.:::     |||    |..|:  ...:.
  Rat   334 RVGTQCAENQMLEEISENVRRRQEDHDQAGQAMHVGDQKEVVDSGDREQ----GTWDSGGQAAEE 394

  Fly   436 QAAAGNKNTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSLLPRS 500
            ::..|..|...|....|.                           |....|.:..||    :|.|
  Rat   395 RSRTGEDNKPCLPMTSIA---------------------------PGVLSPGTLFPA----IPSS 428

  Fly   501 LSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQ-- 563
            :..:| ..::....::|||.:|              ..|...::..|||.|.|.|   |...:  
  Rat   429 VDDMS-QIQREPVPEELTTQAP--------------TPAPEPTEWSHQHISPPAS---FATEEAL 475

  Fly   564 -------QQHRFKETGPTSKGKNKFLISRSL-IEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSH 620
                   ||..||....|...:....:|.|: :.....|.||...||   |:.......|...|.
  Rat   476 DNRTHDSQQEEFKLRKGTISNQGTENVSASISVAPSGTPDLPPFTPP---NVFPTTATFSLVSSS 537

  Fly   621 LVAPVSDLDRATSPQLNRSQQQQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQMESASA 685
            ::.|                                                        |..:.
  Rat   538 VILP--------------------------------------------------------EKETP 546

  Fly   686 AGAAGGSIEVDGGPPPLPPRLPGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQNDNLNI 750
            |.:....|....||...|| ||...|.|....|  :.|.|:|       ||.|.|...|:...| 
  Rat   547 AASISADISPHYGPCETPP-LPAKSTRDPCATS--DTANPHS-------PLTSYTGVTQHLRSN- 600

  Fly   751 AFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITK 815
            :||.|.|..                          |||:       .:|.|....|...|.|   
  Rat   601 SFPGSHRTE--------------------------QTPD-------SMGMSLSFSHLELPQR--- 629

  Fly   816 TTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPNENNRG--------AAAAGPGVFIESHQ 872
                                ||...:..|.:     |..|.|.        ::||...:..:|.:
  Rat   630 --------------------PPKTAIYGSLI-----PRRNRRSRDGVVFSESSAALFALKQDSEE 669

  Fly   873 FTPMAGASSPIPISLHSSHMHAAQS---------------NDTQKEIISMEDENSDLDEP----- 917
            ||     |:|    ..||:.|.:|.               |.:....:||:..:..|..|     
  Rat   670 FT-----SNP----ESSSNPHGSQPWGSPQNSAFAIGSPVNVSSPPTVSMDMIHEALPPPPPEKR 725

  Fly   918 -----FIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWA 977
                 .::.:|.|:.:...|:               .:|.|.||.  |.:.|::....       
  Rat   726 HSYSHIVERDGLFHEVAATLK---------------RHSHPPPLT--LSSGLHRSPKG------- 766

  Fly   978 YEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQ 1042
                |..|||.:.::  ||...|....:                   .....:..|..:||    
  Rat   767 ----SFSLVPDSVVA--RQHRPLPSTPE-------------------GSHHTQTSIPSRLR---- 802

  Fly  1043 KRTAGLGTIYG----PTDDKLAEAKTDKLREQIIDKYLMPN-LHALIEDENGSPPEDVRKVALCS 1102
                     |.    ||.|                   ||. .|:.|...|              
  Rat   803 ---------YNKPLPPTPD-------------------MPEPCHSSISSSN-------------- 825

  Fly  1103 ALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHC 1167
                 |.||:...||.                                 |:              
  Rat   826 -----ISRIYRPLPPV---------------------------------PI-------------- 838

  Fly  1168 QTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIG 1232
                          ||             ..|.|.|||...|                       
  Rat   839 --------------TD-------------PSSEPPPLPPKSR----------------------- 853

  Fly  1233 NEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSC-NTSGLNTTDLQSSFHGS 1296
              :|||   .:.|.:....|||:    |.....|..:|..|.|.||. ..:|.:|..|..:   |
  Rat   854 --ERSR---SVQVGVMHSMGQAN----PRTTGQDWTVSTLSVGRTSWPPATGRSTESLPPT---S 906

  Fly  1297 CANDSINPGGGAGCNMDLSTSVASTTPST------SGSVAAGLSAFAELNALDTVDKEARRERYS 1355
            ..|..::||.......:|.:..:.|||.:      :....:||:..:......:..:.|.:|.::
  Rat   907 RCNSEVSPGLAFSNMTNLLSPSSPTTPWSPELQIPTSKDESGLTEESAPPVRGSFRRPALQEEFN 971

  Fly  1356 QHPKHKSAPVSVNRSES---YK-ERLSNKRNRNSRRKTSDPS-----LSSRPNDEQ--LDLGLSN 1409
            .  ..:||..|..:||.   |: |:.|:..:|....:||:.|     |...||.::  ...||..
  Rat   972 N--TRRSALGSRKKSEKPIHYQLEKASSWPHRRDTARTSESSSEQVVLGQAPNKQKGWNRQGLRR 1034

  Fly  1410 ATYVGSSNSSLSSAGGSESPSTS-----MEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHA--- 1466
            .:.:..|:|.|.:......|.:|     .|.....|..|..:.....:|.:|   ||.|:::   
  Rat  1035 PSILPESSSDLRNPAAGRLPGSSDSVVFREKKPKEGMGGFSRRCSKLINSSQ---LLYQEYSDVV 1096

  Fly  1467 -----QQYCQQDSFQAGLAGAAGSSA--------------------ASNSSFWNAGHPLPVARWT 1506
                 |...:.||    ||...|.|:                    ||:.|.|   ..:||.|  
  Rat  1097 LNKEIQSQQRLDS----LAEPPGISSPRYRRKALVSSDSYLQRLSMASSGSLW---QEIPVVR-- 1152

  Fly  1507 LESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKL-LDRLFFLPLYE 1570
                              .:.||.::|..::|.||...|:..:|.:::|:|.: :|.........
  Rat  1153 ------------------NSTVLLSMTHEDQKLQEAKFELIVSEASYLRSLNIAVDHFQHSTQLR 1199

  Fly  1571 SGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA 1635
            :.|.:|||..|.  ..|..:|::...|...|:: ..|:|.....:.|::.|.......|.|    
  Rat  1200 ATLSNQDHQWLF--SRLQDVRDVSTTFLSDLEE-NFENNIFSFQVCDVVLDHAPDFHRVYL---- 1257

  Fly  1636 AQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYK 1700
             .:...|.......:...|.:...:::|:|.||...|:||.||..|....||:|:..||.:|:.|
  Rat  1258 -PYVTNQTYQERTFQSLMNSNSSFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILK 1321

  Fly  1701 VTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDL 1765
               |..|.::.|||| .:|..:.::::.:.|..|:......:|..:.:|::   ::.:.|..:..
  Rat  1322 ---RTQPGSSEEAEA-TKAHHALEKLIRDCNSNVQRMRRTEELIYLSQKIE---FECKIFPLISQ 1379

  Fly  1766 TQHHLIHDGNLT---------IKKNPS---VQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITN 1818
            :: .|:..|.||         :|:..:   |.||  ||.:.::|...::...:|...|.|.|   
  Rat  1380 SR-WLVKSGELTALEFSVSPGLKRKLTTRPVHLH--LFNDCLLLSRPREGSRFLVFDHAPFS--- 1438

  Fly  1819 KPVSPIMSIDADTL-IRQEAADKNSFFLIKMKTSQMLE----LRAPSSSECKTWFKHFSDVAARQ 1878
                   ||..:.. ::...|.||.|.|..:..:|..:    .|..:.||...|      ::|..
  Rat  1439 -------SIRGEKCEMKLHGAHKNLFRLFLLHNAQGTQAEFLFRTETQSEKLRW------ISALA 1490

  Fly  1879 SKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTP 1943
            ......:....:|:.......|..|..|.:.:|| ..|.|.                        
  Rat  1491 MPREELDLLECYDSPQVQCLRAYKPRENDELALE-KADVVM------------------------ 1530

  Fly  1944 APATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPR-SSQNEVNRTMSIR 1996
              .|..|:...|.||:|.:.::.....: ..::::.|:.| .:..|.:|..:.:
  Rat  1531 --VTQQSSDGWLEGVRLSDGEQGWFPLQ-QVEFISNPEVRVQNLKEAHRVKTAK 1581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 20/114 (18%)
RGS_GEF_like 934..1055 CDD:188710 17/124 (14%)
C1_1 1151..1202 CDD:278556 4/50 (8%)
RhoGEF 1539..1731 CDD:238091 48/192 (25%)
PH_RhoGEF 1770..1875 CDD:275411 27/121 (22%)
DUF2413 2242..>2378 CDD:287302
Arhgef5XP_038964580.1 ARHGEF5_35 1..478 CDD:406010 98/521 (19%)
PHA03247 <395..840 CDD:223021 128/794 (16%)
RhoGEF 1172..1348 CDD:395496 46/187 (25%)
PH_ephexin 1370..1496 CDD:269929 29/144 (20%)
SH3_ARHGEF5_19 1506..1560 CDD:212873 13/81 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.