DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and ARHGEF19

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_694945.2	Gene:	ARHGEF19 / 128272	HGNCID:	26604	Length:	802	Species:	Homo sapiens

Alignment Length:	786	Identity:	156/786 - (19%)
Similarity:	271/786 - (34%)	Gaps:	224/786 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 QTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQA-------------KRLAHNDKISKF 1219
            |.::|.:||.|.. |:......|.........|||..|.|             :|.:|
Human    74 QGLLWPLSPGGSD-TEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPRHTQPQRRASH------- 130

  Fly  1220 MGKIRPRTSDVIGNEKRSR-------QDEELD-------VELTPDRGQASIVRQPSDRRPDANIS 1270
                        |:||:|.       |.||:.       |.|.|  ||....:..|...|...:|
Human   131 ------------GSEKKSAWRKMRVYQREEVPGCPEAHAVFLEP--GQVVQEQALSTEEPRVELS 181

  Fly  1271 IRSNGNTSCNTSG-----LNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVA 1330
                |:|..:..|     .:.::|.:..|.|..         .|.|   |.:.|..:.|.:|:..
Human   182 ----GSTRVSLEGPERRRFSASELMTRLHSSLR---------LGRN---SAARALISGSGTGAAR 230

  Fly  1331 AGLSAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLS 1395
            .|.::          ..|||....|.....:.||......:..:.||..:         .:|.|.
Human   231 EGKAS----------GMEARSVEMSGDRVSRPAPGDSREGDWSEPRLDTQ---------EEPPLG 276

  Fly  1396 SRPNDE--QLDLGLSNATY-----VGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLN 1453
            ||..:|  |....|::..|     |.|:..........|.|....|     ||..|...|...|:
Human   277 SRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAE-----GAEEGPGPPRANLS 336

  Fly  1454 QNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEA 1518
            .:                 .||:     |..|:..|..|.|               :|..||.
Human   337 PS-----------------SSFR-----AQRSARGSTFSLW---------------QDIPDVR-- 362

  Fly  1519 DWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLF 1583
                  .:.|||.|:..:.|.||...|:..:|.:::.:|.:....|......|..|.......||
Human   363 ------GSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLF 421

  Fly  1584 P--PALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFC-ARQQIA 1645
            .  |.:.|..|   .|.|.|:||             |.||:.    ...:|:.....| |.:::.
Human   422 SKLPEVKSTSE---RFLQDLEQR-------------LEADVL----RFSVCDVVLDHCPAFRRVY 466

  Fly  1646 LEALKEKRNKDEMLQKLLKKS----------ESHKACRRLELKDLLPTVLQRLTKYPLLFENLYK 1700
            |..:..:..::...|:||.::          |....|:||.|...|....||:|:..:|.||:.|
Human   467 LPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILK 531

  Fly  1701 VTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDL 1765
            .|.    :.:.:.:...:|..:.|.::.|.|.:|::.:...:|.::.:|:   .::.:.|..:..
Human   532 RTA----QGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKI---HFEGKIFPLISQ 589

  Fly  1766 TQHHLIHDGNLT------------IK-KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSIT 1817
            .: .|:..|.|.            :| .:.:|.||  ||.:.::|..:::...:...:|..:
Human   590 AR-WLVRHGELVELAPLPAAPPAKLKLSSKAVYLH--LFNDCLLLSRRKELGKFAVFVHAKM--- 648

  Fly  1818 NKPVSPIMSIDADTLIRQEAADKNSF----FLIKMKTSQMLE----LRAPSSSECKTWFKHFSDV 1874
                       |:..:|..:......    ||:::...|.::    |||.:.||.:.|.......
Human   649 -----------AELQVRDLSLKLQGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPS 702

  Fly  1875 AARQSK 1880
            :.::.|
Human   703 SPQEDK 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	8/33 (24%)
		RhoGEF	1539..1731	CDD:238091	45/204 (22%)
		PH_RhoGEF	1770..1875	CDD:275411	22/125 (18%)
		DUF2413	2242..>2378	CDD:287302
ARHGEF19	NP_694945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Herpes_ICP4_C	10..>353	CDD:332854	73/362 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..138		14/73 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..190		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..283		15/79 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..342		9/57 (16%)
		RhoGEF	382..558	CDD:306973	43/199 (22%)
		PH_ephexin	580..706	CDD:269929	23/142 (16%)
		SH3_ARHGEF5_19	719..773	CDD:212873
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810