DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and FGD4

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001357227.2	Gene:	FGD4 / 121512	HGNCID:	19125	Length:	903	Species:	Homo sapiens

Alignment Length:	740	Identity:	156/740 - (21%)
Similarity:	267/740 - (36%)	Gaps:	171/740 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1269 ISIRSNGNTSCNTSGLNTTDLQSSFH----GSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSV 1329
            ::||...|.|....|:.....:.:.|    |:.|.....|.|..|         :||.|..:...
Human    12 VAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPSGATG---------SSTCPKIALVP 67

  Fly  1330 AAGLSAFAELNALDTVDKEA------RRERYS------------------------QHPKHKSAP 1364
            ....|:...|...:..::||      |..::|                        |.|:||:.|
Human    68 PCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQNSPSSNIHQTPRHKALP 132

  Fly  1365 VSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESP 1429
            .:..|.|..|...::..::....|.||  |.||     .:.|.|.:.|   |:....||....:|
Human   133 SAKPRMEEIKPASASCVSKEKPSKVSD--LISR-----FEGGSSLSNY---SDLKKESAVNLNAP 187

  Fly  1430 STSMEHFAAPGAAGGVQVPPMGLNQNQHPH-------------------LLIQQHAQQYCQQD-- 1473
            .|       ||..|....|...|.....|.                   ::..|: |..|:::
Human   188 RT-------PGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQN-QMECEEEKA 244

  Fly  1474 -------SFQAG---------------LAGAAGSSA-------ASNSSFW--NAGHPLPVARWTL 1507
                   |.||.               .|.|..|..       ||:||:.  ..|..||:.....
Human   245 ATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGA 309

  Fly  1508 ESEDEDDVNEADWSSMVAAEVLAALTDA----EKKRQEIINEIYQTERNHVRTLKLLDRLFFLPL 1568
            |:|.:....| :..|.:..|.|....:.    |:|..:|.||:..|||.:|..|.|||::|:..|
Human   310 ETETKVQERE-NGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKL 373

  Fly  1569 YESGLLSQDHLLLLFPPALL--------SLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDG 1625
            .|......      ||..::        |:...|..|.....::|::.......|||:|
Human   374 LEEANRGS------FPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL------ 426

  Fly  1626 QSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTK 1690
            |......:...::......|:|.:|....:....:.::::.:..|.|..|.|:..:...:||:.:
Human   427 QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPR 491

  Fly  1691 YPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY 1755
            |    |.|.|..:|.||.::.:....::::|.........|.|::..|:..||..|...|
Human   492 Y----EMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEML----- 547

  Fly  1756 DKEEFKKLDLT--QHHLIHDGNL--TIKKNPSVQLHGL-LFENMIVLLTKQDDKYYLKNLHTPLS 1815
            .:||    |:.  .:.||.:|.:  ...:|.|.|...| ||.||::...   .|:.|
Human   548 GEEE----DIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCV---PKFSL-------- 597

  Fly  1816 ITNK-PVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHFSDV--AAR 1877
            :.:| .|...:.||...::..:..:....|.:..| .:.|||:|.|:.:.:.|.|...:.  |..
Human   598 VGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGK-ERTLELQASSAQDKEEWIKALQETIDAFH 661

  Fly  1878 QSKNRSKNASSNHDTSISDPALAAI 1902
            |.....:||.:..:...|:.:.|.:
Human   662 QRHETFRNAIAKDNDIHSEVSTAEL 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	42/199 (21%)
		PH_RhoGEF	1770..1875	CDD:275411	26/110 (24%)
		DUF2413	2242..>2378	CDD:287302
FGD4	NP_001357227.2	RhoGEF	344..528	CDD:238091	42/199 (21%)
		PH1_FDG4	560..653	CDD:275434	26/104 (25%)
		FYVE_FGD1_2_4	691..755	CDD:277280
		PH2_FGD1-4	774..876	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810