DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and CHN1

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001358443.1	Gene:	CHN1 / 1123	HGNCID:	1943	Length:	476	Species:	Homo sapiens

Alignment Length:	352	Identity:	82/352 - (23%)
Similarity:	123/352 - (34%)	Gaps:	129/352 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   976 WAYEIHSTF-----------LVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILR---------T 1020
            |:..:.|.|           |:|:.|    |....::||..:.|.:..:...::|         |
Human    40 WSAMVRSRFTITSTSRVQAILLPQPP----RFHGMISREAADQLLIVAEGSYLIRESQRQPGTYT 100

  Fly  1021 VFLRSRKRAKDLISEQLREFQ----------QKR--------TAGLGTIYGPTDDKLAE--AK-- 1063
            :.||        ...|.|.|:          :||        |.||.|:|  .:.|.||  ||
Human   101 LALR--------FGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLY--IETKAAEYIAKMT 155

  Fly  1064 ----------TDKLREQIIDKYLMPNLHALIEDENGSPPEDVRKVALCSALSTVIYRIFNTRPPP 1118
                      |...||....|: ||.|....::.:.:..:.|.:..|.|.:.....: .|.:.|.
Human   156 INPIYEHVGYTTLNREPAYKKH-MPVLKETHDERDSTGQDGVSEKRLTSLVRRATLK-ENEQIPK 218

  Fly  1119 SSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTH-CNHCQTIIWGVSPQGYHCT 1182
               .|::|:|               :....||           .| |.:|...:||:..||..|.
Human   219 ---YEKIHNF---------------KVHTFRG-----------PHWCEYCANFMWGLIAQGVKCA 254

  Fly  1183 DCKLNIHRQCSKVVDESCPGPLPQAKRL----------AHNDKISKFMGKIRPRTSDVIGNEKRS 1237
            ||.||:|:||||:|...|...|...|::          ||..|        ||...|:...|..|
Human   255 DCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTK--------RPMVVDMCIREIES 311

  Fly  1238 R--QDEEL-----------DVELTPDR 1251
            |  ..|.|           ||::..||
Human   312 RGLNSEGLYRVSGFSDLIEDVKMAFDR 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710	24/116 (21%)
		C1_1	1151..1202	CDD:278556	19/51 (37%)
		RhoGEF	1539..1731	CDD:238091
		PH_RhoGEF	1770..1875	CDD:275411
		DUF2413	2242..>2378	CDD:287302
CHN1	NP_001358443.1	SH2	67..145	CDD:387587	17/87 (20%)
		C1_1	223..272	CDD:365894	22/74 (30%)
		RhoGAP_chimaerin	283..476	CDD:239837	15/64 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910