DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and fgd1

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_004914246.1	Gene:	fgd1 / 100489369	XenbaseID:	XB-GENE-6453246	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	1015	Identity:	189/1015 - (18%)
Similarity:	326/1015 - (32%)	Gaps:	320/1015 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1331 AGLSAFAELNALDTVDKEARRERYSQHPKHKS-APVSVNRSESYKERL--------SNKRNR--- 1383
            |.:||..|.......|.....:....||...: .|::..||.:.|..:        |.:|.|
Frog    71 AHVSAHPEKPQRQRSDSATSSDYNGVHPDPSTPKPLAPRRSLTPKPEVPPKPAHLQSIRRPRPPG 135

  Fly  1384 -----NSRRKTSDPSLS----SRPND-----------------EQLDLGLSNATYVGSS---NSS 1419
                 .||...:||.|:    |||::                 |.:.|.:...| :|..   |..
Frog   136 HIPPPPSRPLPADPRLARICLSRPDNKDGTPSAVTSLIEKFEREPIILPIERTT-LGHGTDINPD 199

  Fly  1420 LSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQ------------- 1471
            :.|     |||.|::|              .|.:..:..|.|:.....:..|
Frog   200 MDS-----SPSPSLQH--------------SGYSMGELGHKLLDLLEPEVSQGSLERRRRLGVEG 245

  Fly  1472 QDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESE-DEDDVNEADWSSMVAAEVLAALTD- 1534
            .|:.:.|...:.|..|..:|...:...|..........| ||....|::....||....|..::
Frog   246 GDAGEMGEQDSGGKLANRDSGIDSISSPSTSEEMCFLGEVDEGGREESETCYSVAQRCSARDSEG 310

  Fly  1535 -------------------------AEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLL 1574
                                     |.:|..:|.||:.|||:.:|..|.|||::|.     :.|:
Frog   311 DSDMEDGSGDEGELPPERLDPCEFTARQKVYKIANELLQTEKAYVSRLHLLDQVFC-----ARLM 370

  Fly  1575 SQDHLLLLFPPALL--------SLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVL 1631
            .:......||..::        |:...|..|.....::|::.......|||:|      |.....
Frog   371 DEARTRASFPVEVVMGIFSNICSIYCFHQQFLLPELEKRMQEWDSNPRIGDIL------QKLAPF 429

  Fly  1632 CEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFE 1696
            .:...::......|:|.|.....:....:.::::.:..:||..|.|:..:...:||:.:|.||.:
Frog   430 LKMYGEYVKNFDRAMELLNVWTERSSQFKSVIQEVQREEACGNLTLQHHMLEPVQRIPRYELLLK 494

  Fly  1697 N-LYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEF 1760
            : |.|     |||::.:....::::|.........|.|::..|..|||..:...|     ..||
Frog   495 DYLLK-----LPEDSKDRCDAEKSLELIATAAEHSNAAIRKMERMHKLLKVYELL-----GGEE- 548

  Fly  1761 KKLDLTQ--HHLIHDGN---LTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKP 1820
               |:..  :.||.:|:   |:.|...:...:.:||.:.::....:            |.:..:.
Frog   549 ---DIVSPTNELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPK------------LRLIGQK 598

  Fly  1821 VSPIMSIDADTLIRQEAADKNSFFLIKMKTSQ-MLELRAPSSSECKTWFKHFSDVAARQSKNRSK 1884
            .|....||.:.:..:.::..|.....::...| .|||:|.:..|.|.|.:     |...:.||
Frog   599 YSVRARIDVEGMELKHSSSPNLTRTFRVSGKQRSLELQARTEEEKKDWIQ-----AIEATINR-- 656

  Fly  1885 NASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNN 1949
                               |....||.:|...:::     ....|.|.:|...:....|.|.
Frog   657 -------------------HEQAMESCKLLCTSIR-----EDEETPPNSPNTDLGKRAPTPI--- 694

  Fly  1950 SNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEAND 2014
                                               .:.||...|..:   ||.          |.
Frog   695 -----------------------------------REKEVTMCMKCQ---EPF----------NS 711

  Fly  2015 VTLR--HSQSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTL----LMQSPLV 2073
            :|.|  |.::...                :|.|......|.:|..||..|...:    .::..|.
Frog   712 ITKRRHHCKACGH----------------VVCGKCSEFRARLVYDNNRTNRVCVDCYGALRGSLA 760

  Fly  2074 DPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQ-------KIICDI------------ 2119
            .|      :..|||.:.               |..:||||       .::|..
Frog   761 SP------VYNAHTPQR---------------RKSILEKQASVVAEHSVMCSYMHYMEKGAKSWH 804

  Fly  2120 ---FRLPVEHYDQIVDIAMMPEAPKDSADIALAAYDQIQTLTKMLNEYMHV------------TP 2169
               |.:| ::...::.|...|:..|....|.|..::...|.....::..||            :|
Frog   805 KAWFVIP-QNEPLVLYIYGAPQDVKAQRSIPLIGFEVSPTEPGERSDRRHVFKISQSQLSFYFSP 868

  Fly  2170 EQE------VSAVSTAVCGH-CHEKEKLRKKVAPSSSFSS 2202
            |.|      |||:|.|..|. ||.|..|.:....|..|.|
Frog   869 ETEELQSRWVSALSRAGRGEDCHPKILLLETEEESEVFES 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	42/200 (21%)
		PH_RhoGEF	1770..1875	CDD:275411	20/108 (19%)
		DUF2413	2242..>2378	CDD:287302
fgd1	XP_004914246.1	PHA03247	<6..207	CDD:223021	31/141 (22%)
		RhoGEF	341..525	CDD:238091	42/199 (21%)
		PH1_FGD1	557..664	CDD:275392	25/144 (17%)
		FYVE_FGD1_2_4	691..755	CDD:277280	18/130 (14%)
		PH2_FGD1-4	780..885	CDD:270056	18/105 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910