DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Plekhg6

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_002729474.2	Gene:	Plekhg6 / 100362241	RGDID:	2318544	Length:	783	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	187/855 - (21%)
Similarity:	306/855 - (35%)	Gaps:	211/855 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1388 KTSDPSLSSRPNDEQLDLGLSNA---TYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPP 1449
            :|.||     ||:..|. ||..:   ||.|...:|..|:.|...|            .||   |.
  Rat     2 QTFDP-----PNEGPLQ-GLVASRIETYGGRHQTSAQSSAGITYP------------RGG---PA 45

  Fly  1450 MGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHP--------------- 1499
            :.|::.:      .||...:.:......||:.........:.:::..|.|
  Rat    46 LDLSRRR------LQHYVPFAKGSGQTRGLSPQEPDPEKRHGNYFGVGSPYFPKFKEVSKAHELE 104

  Fly  1500 -------------LPV---ARWTL-ESEDEDDVNEADWSSMVAAEVLAALTDAEKKR-----QEI 1542
                         ||.   ..|.: |..|.....|..|..:|       |...|..|     ||.
  Rat   105 VRLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTIEKSWKELV-------LGHKEMNRELCHQQEA 162

  Fly  1543 INEIYQTERNHVRTLKLLDRLF---FLPLYESGLLSQDHLLLLF--PPALLSLREIHGAFEQSLK 1602
            :.|:..||..::|.||::..|.   .|.|...|||::.....||  .|.|:   ..|..|.:.:.
  Rat   163 LWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETLFGNVPKLI---RTHRRFWEEVL 224

  Fly  1603 QRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA------AQFCARQQIALEALKEKRNKDEMLQK 1661
            |..:|.   ..|.|..| |....|:|.:  .|.      .|:|.|.:..:...:|:::.:.:.:.
  Rat   225 QPILED---TRTSGQPL-DPVSLQNGFL--TFGQRFQPYIQYCLRVKQTMAYAREQQDTNPLFRT 283

  Fly  1662 LLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRI 1726
            .::..|.||...|..|.|||....||:||||||.:.:.|.:    ||...:. |:...:.:.:..
  Rat   284 FVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVLKRS----PEPRAQL-ALDNMIVAVESF 343

  Fly  1727 LVEVNQAVKTAEDAHKLQNIQRK------LDRSSYDKE----EFKKLDL----------TQHHLI 1771
            |..:|..|:..|:...|..:.::      |:.||.:.|    :|..|||          ....|:
  Rat   344 LQHINGLVRRGEEQESLMAVAQRIGPYEVLEPSSEEVEKHLRQFSTLDLMTPIEGVAPENTRQLL 408

  Fly  1772 HDGNLTIK--KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIR 1834
            .:|.:.:|  :...:.::..||.: ::|:||...|.....:..|         |:|   .:.|:.
  Rat   409 LEGPVRMKEGREGKMDVYLFLFSD-VLLVTKPQRKVDKAKVIRP---------PLM---LEKLVC 460

  Fly  1835 QEAADKNSFFLIKMK----TSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSIS 1895
            :...|.:||.||.:.    .|..|.:...||:|...|.:......|...|.:::....      .
  Rat   461 RPLRDPHSFLLIHLTEFQCVSSALTVHCSSSTERTQWLQKTQQAQATLQKLKAEEYVQ------Q 519

  Fly  1896 DPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLA-PMLPIATVTPAPATNNSNVSSLTGVQ 1959
            ...|.|:.....:||......|..|..:.::.....|. .::|...||.....:..:|
  Rat   520 KRGLLALYRDQGRESPSPRPSTPSPEDSQSSAEGRALEFTVIPRLVVTEDTDEDTPSV------- 577

  Fly  1960 LRNPQRDATASESDADY--VNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQS 2022
                    |...||:.|  :....|:.||:.:||..|.....:|...:|.  .|..||.||....
  Rat   578 --------TDDTSDSGYGTLIPSSPKDSQSPLNRLRSKALRRDPRLTFST--LELRDVPLRPQPP 632

  Fly  2023 TRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRT-----------LLMQSPLVDPT 2076
            ..::::..|..|   ...|::.|.|....|....|...:.|.|           ...:|||..
  Rat   633 DPQALQRRSAPE---MPEGILRGGSLPRRAPPTWSEEEDETLTPGNVVVETLSRAQRRSPLPH-- 692

  Fly  2077 AIQVSISPAHT-------------AEPVLTPGEKLRRLDASIRNDLLEKQKIICDIFRLPVEHYD 2128
                  |||||             .|..|:||.:.|.|.|   .|:|.:         :..|...
  Rat   693 ------SPAHTDSAGESPWESTDEDEGPLSPGLRPRSLRA---EDMLRE---------IREELAS 739

  Fly  2129 QIVDIAMMPE 2138
            |.::.|:.||
  Rat   740 QRIEGALEPE 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	55/207 (27%)
		PH_RhoGEF	1770..1875	CDD:275411	24/110 (22%)
		DUF2413	2242..>2378	CDD:287302
Plekhg6	XP_002729474.2	RhoGEF	162..348	CDD:395496	52/199 (26%)
		PH_PLEKHG5_G6	405..503	CDD:270064	24/110 (22%)
		fibronec_FbpA	<566..761	CDD:411474	51/224 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740