DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dark and Apaf1

DIOPT Version :9

Sequence 1:NP_725637.1 Gene:Dark / 36914 FlyBaseID:FBgn0263864 Length:1440 Species:Drosophila melanogaster
Sequence 2:NP_076469.1 Gene:Apaf1 / 78963 RGDID:620575 Length:1249 Species:Rattus norvegicus


Alignment Length:1519 Identity:297/1519 - (19%)
Similarity:523/1519 - (34%) Gaps:437/1519 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 DAFVDNFDCKDVQDMPKSILSKEEIDHII-------MSKDAVSG-------TLRLFWTLLSKQEE 71
            ||...|...:..:.:.|.|.:...:||:|       :.::.|..       ...|...:|:|...
  Rat     2 DAKARNCLLQHKEALEKDIKTSYIMDHMISNGVLTVVEEEKVKSQATQYQRAAALIKMILNKDNY 66

  Fly    72 MVQKFVEEVLRINYKFLMS------PI-------KTEQRQPSMMTRMYIE----QRDRLYNDNQV 119
            ....|...:|...||.|..      |:       .|:....|.:..:..|    ||..::    |
  Rat    67 AYISFYNALLHEGYKDLAGLLHSGLPLVSSSSGKDTDGGNTSFVRTVLCEGGVPQRPVIF----V 127

  Fly   120 FAKYNVSRLQPYLKLRQALLELRPAKN-VLIDGVLGSGKTWVA---------LDVCLSYKVQCKM 174
            ..|..||.:|      |.|.:|..... |.|.|:.|.||:.:|         |:.|.|..|.   
  Rat   128 TRKKLVSAIQ------QKLWKLNGEPGWVTIYGMAGCGKSVLAAEAVRDHALLEGCFSGGVH--- 183

  Fly   175 DFKIFWLNLKNCNSPETVLEMLQKLLYQIDPNWTSRSDHSSNIKLRIHSIQAELRRLLKSKPYEN 239
                 |:::.. .....:|..||.|..::.    .....|..:.|.|...:..||.|:..| :..
  Rat   184 -----WVSIGK-QDKSGLLMKLQNLCTRLG----QEESFSQRLPLNIEEAKDRLRVLMLRK-HPR 237

  Fly   240 CLLVLLNVQNAKAWNAFNLSCKILLTTRFKQVTDFLSAATTTHISLDHHSMTLTPDEVKSLLLKY 304
            .||:|.:|.:.....||:..|:||||||.|.|||.:...... |.::   ..|..::...:|..:
  Rat   238 SLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGPKYV-IPVE---SGLGKEKGLEILSLF 298

  Fly   305 LDCRPQDLPREVLTT------NPRRLSIIAESIRDGLATW---------DNWKHV------NCDK 348
            ::.:.:|||.|..:.      :|..:|::...:||....|         ..:|.:      :.:.
  Rat   299 VNMKKEDLPVEAHSIIKECKGSPLVVSLVGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEA 363

  Fly   349 LTTIIESSLNVLEPAEYRKMFDRLSVFPPSAHIPTILLSLIWFDVIKSDVMVVVNKLHKYSLV-- 411
            |...:..|:.:|. .:.:..:..||:......:||.:|.::| |:...:|..::.:....||:  
  Rat   364 LDEAMSISVEMLR-EDIKDYYTDLSILQKDVKVPTKVLCVLW-DLETEEVEDILQEFVNKSLLFC 426

  Fly   412 EKQPKESTISIPSIYLEL-----KVKLENEYALHRSIV---DHYNIPKTFDSDDLIPPYLD-QYF 467
            .:..|.....:..:.::.     :.:|::   |||.:|   ..|:.|.|     |.|...| .|:
  Rat   427 NRNGKSFCYYLHDLQVDFLTEKNRSQLQD---LHRKMVTQFQRYHQPHT-----LSPGQEDCMYW 483

  Fly   468 YSHIGHHLKNI-EHPERMTLFRMVFLDFRFLEQKIRHDSTAW-NASGSILNTLQQLKFYKPY--- 527
            |:.:.:|:.:. .|.|...|  |..||              | .|...::.....:..:..|   
  Rat   484 YNFLAYHMASAGMHKELCAL--MFSLD--------------WIKAKTELVGPAHLIHEFVEYRHI 532

  Fly   528 -------ICDNDPKYERLVNAILDFLPKIEENLICSKYTDLLRIALM-AEDEAIFEEAHKQVQRF 584
                   :|:|..::..|...:|...|          :.:::::.|. .|...::::|..|.::.
  Rat   533 LDEKDCAVCENFQEFLSLNGHLLGRQP----------FPNIVQLGLCEPETSEVYQQAKLQAKQE 587

  Fly   585 DDRVWFTNHGRFH----QHRQIINLGDNEGRHAVYLHNDFCLIALAS--GQILLT---DVSLE-- 638
            .|.      ||.:    ..:.|.||    .|..|..|.|....|..|  ||.:.:   |.:|:  
  Rat   588 VDT------GRLYLEWINKKTIKNL----SRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVF 642

  Fly   639 ----GEDTYLLRDESDSSDILRMAVFNQQKHLITLHCNGSVKLWSLWPDCPGRRHSGGSKQQLVN 699
                ||.  ||..::...::|..|..:...::.|...:..||:|.          ||..|     
  Rat   643 KAETGEK--LLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWD----------SGTGK----- 690

  Fly   700 SVVKRFIGSYANLKIVAFYLNEDAGLPEANIQLHVAFING--DVSILNWDEQDQEFKLSHVPVLK 762
             :|..:......:....|          .|...|:....|  |..:..||...:|.:       .
  Rat   691 -LVHTYEEHSEQVNCCHF----------TNKSNHLLLATGSNDSFLKLWDLNQKECR-------N 737

  Fly   763 TM----QSGIRCFVQVLKRYYVVCTSNCTLTVWDLTNGSSNTLELHVFNVENDTPLALDVFDERS 823
            ||    .|...|...........|:::.||.:||:.:.:                        ..
  Rat   738 TMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSAN------------------------EK 778

  Fly   824 KTATVLLIFKYSVWRLNFLPGLSVSLQSEAVQLPEGSFITCGKRSTDGRYLLLGTSEGLIVYDLK 888
            |:..|...|            ||.....|.|::    .:.|...|.||..:::.....:::.|:.
  Rat   779 KSINVKRFF------------LSSEDPPEDVEV----IVKCCSWSADGDRIIVAAKNKVLLLDIH 827

  Fly   889 ISDPVLRSNVSEH--IECVDIYELFDPVYKYIVLCGAKGKQVVHVHTLRS---VSGSNSHQNREI 948
            .|..:...:...|  |:..|    |.| |.::.:. |..:..|.:..:.|   |:....|    :
  Rat   828 TSGLLTEIHTGHHSTIQYCD----FSP-YDHLAVI-ALSQYCVELWNIDSRVKVADCRGH----L 882

  Fly   949 AWVH----SADEISVMT-------------KACLEPNVYLRSLMDMTRERTQL--LAVDSKERIH 994
            :|||    |.|..|.:|             |.|....:.|:..:|:..:..::  ||||:...:.
  Rat   883 SWVHGVMFSPDGSSFLTASDDQTIRVWETRKVCKNSAIVLKQEIDVVFQENEMMVLAVDNIRGLQ 947

  Fly   995 LIKPAISRISEWSTITPTHAASNCKIN---AISAFNDEQIFVGYVD---------GV----IIDV 1043
            ||.....:|.    ..|....|.|.::   ...||.||:..:..::         |:    .:..
  Rat   948 LIAGKTGQID----YLPEAQVSCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRH 1008

  Fly  1044 IHDTALPQQFIEEPIDYLKQV----SPNILVASAHSAQKTV-IFQLEKIDPLQPNDQWPLMMDVS 1103
            |..||..:..|....|.:.||    :...:...||  |:|| .|:|.:...|.   .|  ..|.:
  Rat  1009 IQFTADGKTLISSSEDSVIQVWNWQTEEYVFLQAH--QETVKDFRLLRDSRLL---SW--SFDGT 1066

  Fly  1104 TKYASLQEGQYIILFSDHGVCHLDIANPSAFVK----PKDSEEYIVGFDLKNSLLFLAYENNII- 1163
            .|..::..|:....|:.|....|..|..|...|    ..|....|..|:|.:.|..|...|:.: 
  Rat  1067 VKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHELKGHNSCVR 1131

  Fly  1164 -DVFRLIFSCNQLRYEQICEEEIAQKAKISYLVATDDGTMLAMGFENGTLELFAVENRKVQLIY- 1226
             ..|.|                              ||.:||.|.:||.:.::.|.:.  ||:: 
  Rat  1132 CSAFSL------------------------------DGILLATGDDNGEIRIWNVSDG--QLLHL 1164

  Fly  1227 ----SIEE---VHEHCIRQLLFSPCKLLLISCAEQLCFWNVTHMRNNQLEREQKRRRSRRHKQHS 1284
                ||||   .|...:..:.|||.:.:|:|....|.:|||....::|                 
  Rat  1165 CAPISIEEGTATHGGWVTDVCFSPDRKMLVSAGGYLKWWNVVTGESSQ----------------- 1212

  Fly  1285 VTQEDAVDAAPIAADIDVDVTFVADEFHPVNRGTAELWRNKRGNAIRPELLACVKFVGNEARQFF 1349
                                ||..:                                |...::..
  Rat  1213 --------------------TFYTN--------------------------------GTNLKKIH 1225

  Fly  1350 TDAHFSHFYAIDDEGVYYHLQLLE 1373
            ....|..:..:|:.|:.|.||:||
  Rat  1226 VSPDFRTYVTVDNLGILYILQVLE 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DarkNP_725637.1 NB-ARC 133..390 CDD:279299 64/287 (22%)
Apaf1NP_076469.1 CARD_APAF1 7..92 CDD:260034 15/84 (18%)
AAA_16 126..245 CDD:289934 34/142 (24%)
NB-ARC 129..414 CDD:279299 71/310 (23%)
WD40 <598..685 CDD:225201 22/92 (24%)
WD40 607..910 CDD:238121 72/387 (19%)
WD 1-1 613..652 11/40 (28%)
WD40 repeat 623..655 CDD:293791 9/33 (27%)
WD40 653..1038 CDD:225201 84/471 (18%)
WD 1-2 655..694 10/54 (19%)
WD40 repeat 661..697 CDD:293791 10/51 (20%)
WD 1-3 697..738 8/57 (14%)
WD40 repeat 702..740 CDD:293791 9/54 (17%)
WD 1-4 741..780 7/62 (11%)
WD40 repeat 747..789 CDD:293791 9/77 (12%)
WD 1-5 796..837 7/44 (16%)
WD40 repeat 801..837 CDD:293791 6/35 (17%)
WD 1-6 838..877 10/44 (23%)
WD40 repeat 843..882 CDD:293791 10/48 (21%)
WD 1-7 880..910 8/33 (24%)
WD40 repeat 885..909 CDD:293791 6/23 (26%)
Interpropeller linker. /evidence=ECO:0000250 910..921 2/10 (20%)
WD 2-1 922..958 9/39 (23%)
WD 2-2 959..998 7/38 (18%)
WD40 961..1235 CDD:238121 70/381 (18%)
WD40 961..>1235 CDD:225201 70/381 (18%)
WD40 repeat 964..1001 CDD:293791 7/36 (19%)
WD 2-3 1001..1040 7/38 (18%)
WD40 repeat 1006..1030 CDD:293791 6/23 (26%)
WD 2-4 1042..1080 12/44 (27%)
WD40 repeat 1048..1082 CDD:293791 7/38 (18%)
WD 2-5 1083..1122 10/38 (26%)
WD40 repeat 1089..1124 CDD:293791 9/34 (26%)
WD 2-6 1125..1164 13/70 (19%)
WD40 repeat 1130..1174 CDD:293791 16/75 (21%)
WD 2-7 1176..1213 11/73 (15%)
WD40 repeat 1181..1203 CDD:293791 6/21 (29%)
WD 2-8 1214..1249 8/66 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340781
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4658
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 82 1.000 Inparanoid score I5107
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D40665at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.850

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