DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dark and APAF1

DIOPT Version :9

Sequence 1:NP_725637.1 Gene:Dark / 36914 FlyBaseID:FBgn0263864 Length:1440 Species:Drosophila melanogaster
Sequence 2:NP_863651.1 Gene:APAF1 / 317 HGNCID:576 Length:1248 Species:Homo sapiens


Alignment Length:1532 Identity:274/1532 - (17%)
Similarity:537/1532 - (35%) Gaps:464/1532 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 DAFVDNFDCKDVQDMPKSILSKEEIDHIIMSKDAVSGTLRLFWTLLSKQEEMVQKFVEEVLRINY 85
            ||...|...:..:.:.|.|.:...:||:|...         |.|:  .:||.|:.          
Human     2 DAKARNCLLQHREALEKDIKTSYIMDHMISDG---------FLTI--SEEEKVRN---------- 45

  Fly    86 KFLMSPIKTEQRQPSMMTRMYIEQRDRLYNDNQV----------------------------FAK 122
                .|  |:|::.:|:.:|.:::.    ||:.|                            ..|
Human    46 ----EP--TQQQRAAMLIKMILKKD----NDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGK 100

  Fly   123 YNVSRLQPYLK------------------------LRQALLELRPAKN-VLIDGVLGSGKTWVAL 162
            .:||.:..|::                        ::|.|.:|:.... |.|.|:.|.||:.:|.
Human   101 DSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAA 165

  Fly   163 DVCLSYKV--QCKMDFKIFWLNLKNCNSPETVLEMLQKLLYQIDPNWTSRSDHSSNIKLRIHSIQ 225
            :....:.:  .| ....:.|:::.. .....:|..||.|..::|      .|.|.:.:|.::..:
Human   166 EAVRDHSLLEGC-FPGGVHWVSVGK-QDKSGLLMKLQNLCTRLD------QDESFSQRLPLNIEE 222

  Fly   226 AELR-RLLKSKPYENCLLVLLNVQNAKAWNAFNLSCKILLTTRFKQVTDFLSAATTTHISLDHHS 289
            |:.| |:|..:.:...||:|.:|.::....||:..|:||||||.|.|||.:...... :.::   
Human   223 AKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYV-VPVE--- 283

  Fly   290 MTLTPDEVKSLLLKYLDCRPQDLPREVLTT------NPRRLSIIAESIRDGLATWDNW-KHVNCD 347
            .:|..::...:|..:::.:..|||.:..:.      :|..:|:|...:||....|:.: |.:...
Human   284 SSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNK 348

  Fly   348 KLTTIIESS---LNVLEPA----------EYRKMFDRLSVFPPSAHIPTILLSLIWFDVIKSDVM 399
            :...|.:||   ...|:.|          :.:..:..||:......:||.:|.::| |:...:|.
Human   349 QFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILW-DMETEEVE 412

  Fly   400 VVVNKLHKYSLV--EKQPKESTISIPSIYL-ELKVKLENE------YALHRSIV---DHYNIPKT 452
            .::.:....||:  ::..|..     ..|| :|:|....|      ..||:.|:   ..|:.|.|
Human   413 DILQEFVNKSLLFCDRNGKSF-----RYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHT 472

  Fly   453 F--DSDDLIPPYLDQYFYSHIGHHLKNIE-HPERMTLFRMVFLDFRFLEQKIRHDSTAW-NASGS 513
            .  |.:|.:      |:|:.:.:|:.:.: |.|...|  |..||              | .|...
Human   473 LSPDQEDCM------YWYNFLAYHMASAKMHKELCAL--MFSLD--------------WIKAKTE 515

  Fly   514 ILNTLQQLKFYKPY----------ICDNDPKYERLVNAILDFLPKIEENLICSKYTDLLRIALM- 567
            ::.....:..:..|          :.:|..::..|...:|...|          :.:::::.|. 
Human   516 LVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQP----------FPNIVQLGLCE 570

  Fly   568 AEDEAIFEEAHKQV-QRFDDRV----WFTNHGRFHQHRQIINLGDNEGRHAVYLHNDFCLIALAS 627
            .|...::::|..|. |..|:.:    |.......:..|.::....:...||.:..:...:.:..:
Human   571 PETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGA 635

  Fly   628 GQILLTDVSLEGEDTYLLRDESDSSDILRMAVFNQQKHLITLHCNGSVKLWSLWPDCPGRRHSGG 692
            .:.|....:..||.  ||..::...::|..|.....:.:.|...:..||:|              
Human   636 DKTLQVFKAETGEK--LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW-------------- 684

  Fly   693 SKQQLVNSVVKRFIGSY----ANLKIVAFYLNEDAGLPEANIQLHVAFING--DVSILNWDEQDQ 751
                  ||:....:.:|    ..:....|          .|...|:....|  |..:..||...:
Human   685 ------NSMTGELVHTYDEHSEQVNCCHF----------TNSSHHLLLATGSSDCFLKLWDLNQK 733

  Fly   752 EFKLSHVPVLKTM----QSGIRCFVQVLKRYYVVCTSNCTLTVWDLTNGSSNTLELHVFNVENDT 812
            |.:       .||    .|...|......:....|:::.||.:||.|:.                
Human   734 ECR-------NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA---------------- 775

  Fly   813 PLALDVFDERSKTATVLLIFKYSVWRLNFLPGLSVSLQSEAVQLPEGSFITCGKRSTDGRYLLLG 877
                   :|| |:..|...|            |::....|.:::    .:.|...|.||..:::.
Human   776 -------NER-KSINVKQFF------------LNLEDPQEDMEV----IVKCCSWSADGARIMVA 816

  Fly   878 TSEGLIVYDLKISDPVLRSNVSEH--IECVDIYELFDP--------VYKYIVLCGAKGKQVVHVH 932
            ....:.::|:..|..:...:...|  |:..|    |.|        :.:|.|       ::.:..
Human   817 AKNKIFLFDIHTSGLLGEIHTGHHSTIQYCD----FSPQNHLAVVALSQYCV-------ELWNTD 870

  Fly   933 TLRSVSGSNSHQNREIAWVH----SADEISVMT-------------KACLEPNVYLRSLMDMTRE 980
            :...|:....|    ::|||    |.|..|.:|             |.|....|.|:..:|:..:
Human   871 SRSKVADCRGH----LSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQ 931

  Fly   981 RTQ--LLAVDSKERIHLIKPAISRISEWSTITPTHAASNCKINAIS--AFNDEQIFVGYVDGVII 1041
            ..:  :||||...|:.||.   .|..:...:|....:..|....:.  ||.||.   |.::  |:
Human   932 ENEVMVLAVDHIRRLQLIN---GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDEN---GAIE--IL 988

  Fly  1042 DVIHDTALPQQFIEEPIDYLKQVSPN--ILVASAHSAQKTV-IFQLEKIDPLQPNDQWPLMMDVS 1103
            :::::.....:|..:...:..|.:.:  .|::|:..|:..| .:||:|...|:.:.:       :
Human   989 ELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE-------T 1046

  Fly  1104 TKYASLQEGQYIILFSDHGVCHLDIANPSAFVKPKDSEEYIVGFDLKNSLLFLAYENNII--DV- 1165
            .|...|.:...::.:|..|.  :.:.|.....|.||               |:.::..::  |: 
Human  1047 VKDFRLLKNSRLLSWSFDGT--VKVWNIITGNKEKD---------------FVCHQGTVLSCDIS 1094

  Fly  1166 -------------------FRLIFSCNQLRYEQICEEEIAQKAKISYLVATDDGTMLAMGFENGT 1211
                               |.|:...::||....|         :.....:.|.|:||.|.:||.
Human  1095 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGC---------VRCSAFSVDSTLLATGDDNGE 1150

  Fly  1212 LELFAVENRK-VQLIYSIEE----VHEHCIRQLLFSPCKLLLISCAEQLCFWNVTHMRNNQLERE 1271
            :.::.|.|.: :.|...:.|    .|...:..|.|||...:|||....:.:|||....::|    
Human  1151 IRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ---- 1211

  Fly  1272 QKRRRSRRHKQHSVTQEDAVDAAPIAADIDVDVTFVADEFHPVNRGTAELWRNKRGNAIRPELLA 1336
                                             ||..:                           
Human  1212 ---------------------------------TFYTN--------------------------- 1216

  Fly  1337 CVKFVGNEARQFFTDAHFSHFYAIDDEGVYYHLQLLE 1373
                 |...::......|..:..:|:.|:.|.||.||
Human  1217 -----GTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DarkNP_725637.1 NB-ARC 133..390 CDD:279299 63/304 (21%)
APAF1NP_863651.1 CARD_APAF1 7..92 CDD:260034 19/115 (17%)
NB-ARC 129..374 CDD:395745 58/256 (23%)
APAF1_C 453..587 CDD:407760 28/165 (17%)
WD40 607..910 CDD:238121 64/396 (16%)
WD 1-1 613..652 6/40 (15%)
WD40 repeat 623..655 CDD:293791 5/33 (15%)
WD 1-2 655..694 8/58 (14%)
WD40 repeat 660..697 CDD:293791 9/56 (16%)
WD 1-3 697..738 8/57 (14%)
WD40 repeat 703..741 CDD:293791 10/54 (19%)
WD 1-4 741..780 10/62 (16%)
WD40 repeat 746..791 CDD:293791 13/80 (16%)
WD 1-5 796..836 6/43 (14%)
WD40 repeat 802..870 CDD:293791 13/78 (17%)
WD 1-6 838..877 8/49 (16%)
WD 1-7 880..910 8/33 (24%)
WD40 repeat 885..939 CDD:293791 11/53 (21%)
Interpropeller linker. /evidence=ECO:0000250 910..921 2/10 (20%)
WD 2-1 922..958 10/38 (26%)
WD 2-2 959..998 8/43 (19%)
WD40 961..1234 CDD:238121 59/379 (16%)
WD40 repeat 964..990 CDD:293791 7/30 (23%)
WD 2-3 1001..1040 8/38 (21%)
WD40 repeat 1006..1030 CDD:293791 4/23 (17%)
WD 2-4 1042..1080 6/46 (13%)
WD40 repeat 1047..1082 CDD:293791 8/51 (16%)
WD 2-5 1083..1122 3/38 (8%)
WD40 repeat 1089..1124 CDD:293791 3/34 (9%)
WD 2-6 1125..1164 10/47 (21%)
WD40 repeat 1130..1172 CDD:293791 11/41 (27%)
WD 2-7 1175..1212 12/73 (16%)
WD40 repeat 1180..1213 CDD:293791 11/69 (16%)
WD 2-8 1213..1248 8/66 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147117
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4658
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 62 1.000 Inparanoid score I5386
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D40665at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.850

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