DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dark and apaf1

DIOPT Version :9

Sequence 1:NP_725637.1 Gene:Dark / 36914 FlyBaseID:FBgn0263864 Length:1440 Species:Drosophila melanogaster
Sequence 2:XP_012815297.2 Gene:apaf1 / 100127738 XenbaseID:XB-GENE-988968 Length:1248 Species:Xenopus tropicalis


Alignment Length:1492 Identity:286/1492 - (19%)
Similarity:523/1492 - (35%) Gaps:434/1492 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 ILSKEEIDHIIMSKDAVSGTLRLFWTLLSKQEEMVQKFVEEVLRINYKFLM--------SPIKTE 95
            :::.||...:...:..:.....|...:|.|..:....|...:|...||.|.        :.:...
 Frog    34 VITPEEEAQVKSQRTQMDKANFLINLILGKSNQAYVSFYNALLHEGYKDLAVLLKEAANAELSDS 98

  Fly    96 QRQPSMMTRMYIE---------QRDRLYNDNQVFAKYNVSRLQPYLKLRQALLELRPAKN-VLID 150
            .:..|.....|::         ||..::          |:||:...|::|:|.:|..... |.:.
 Frog    99 TKSSSNGITSYVKTVLCEGAVPQRPVVF----------VTRLKLVSKIQQSLYKLSVESGWVTVY 153

  Fly   151 GVLGSGKTWVALDVCLSYKV--QCKMDFKIFWLNLKNCNSPETVLEMLQKLLYQIDPNWTSRSDH 213
            |:.|.|||.:|.:....:|:  :| ....:.|:::.. .....:|..||.|..::|    ..:.:
 Frog   154 GMAGCGKTVLAAEALRDHKILNEC-FPGGVHWVSVGR-QDKAGLLMKLQNLCTRLD----QEAKY 212

  Fly   214 SSNIKLRIHSIQAELRRLLKSKPYENCLLVLLNVQNAKAWNAFNLSCKILLTTRFKQVTDFLSA- 277
            |....|.....:..| ||:.::.|..||:||.:|.::....||::.|::|:|:|.|.|||.|.. 
 Frog   213 SQRPPLNAEEARERL-RLMVNRMYPRCLIVLDDVWDSWVLKAFDIQCRVLITSRDKSVTDSLPGF 276

  Fly   278 ATTTHISLD-HHSMTLTPDEVKSLLLKYLDCRPQDLPREVLTT------NPRRLSIIAESIRDGL 335
            ....|:..: .||..|      .:|.::|:.:.:.||.:....      :|..:|:|...:|:..
 Frog   277 KEAVHVDSELEHSKGL------EILSRFLNIKAEALPSQAHNIIKESKGSPLVVSLIGALLREFP 335

  Fly   336 ATWD---------NWKHV------NCDKLTTIIESSLNVLEPAEYRKMFDRLSVFPPSAHIPTIL 385
            ..||         .:|.:      :.:.|...:..|::.|: .::::.::..|:......:||.:
 Frog   336 TRWDFYLTQLKRKQFKRIRKSSSYDYEALDEAMSISVDNLK-EDFKEYYNDFSIIEKDVKVPTQV 399

  Fly   386 LSLIWFDVIKSDVMVVVNKLHKYSLV--EKQPKESTISIPSIYLELKVKLENE--YALHRSIVDH 446
            |.::| |:.:.||..::.:....|||  ::..|..:..:..:.|:...:...:  ..||..:||.
 Frog   400 LCILW-DMEREDVEDMMQEFVNKSLVYCDRNGKSYSYYLHDLQLDYLTERNRDRLTVLHSKLVDQ 463

  Fly   447 YNIPKTFDSDDLIPPYLDQ----YFYSHIGHHL--KNIEHPERMTLFRMVFLDFRFLEQKIRHDS 505
            |.  |.:.|..   |.:||    |:|.::.:|:  .|:.......||.:.:|             
 Frog   464 YK--KHYSSKS---PAVDQEDSVYWYHYLAYHMAKANMHQDLCSLLFSLNWL------------- 510

  Fly   506 TAWNASGSILNTLQQLKFYKPY--ICDNDPKYERLVNAILDFLPKIEENLICSKYTDLLRIAL-M 567
               .|...:..|...:..:..|  |.||.....|  ....:|:......|..:....::::.| .
 Frog   511 ---KAKTELFGTAHLIHEFVQYRNILDNQNAKAR--EHFQEFIAVNGHLLGSNPDVSIVQLGLGQ 570

  Fly   568 AEDEAIFEEAHKQV-QRFDDRVWFTNHGRFHQHRQIINLGDNEGRHAVYLHNDFCLIALASGQIL 631
            |||..::::|..|. :.......:.|.......:.:..|.....:.||: |..|.    :.||.:
 Frog   571 AEDSEVYKQAILQAKEELQSGALYVNWINKQSMKNLPTLVVRPHKDAVF-HACFS----SDGQRI 630

  Fly   632 LT---DVSLE------GEDTYLLRDESDSSDILRMAVFNQQKHLITLHCNGSVKLWSLWPDCPGR 687
            .:   |.:|:      ||.  ||..|:...::|..|....:|.|.|...:..||:|         
 Frog   631 ASCGADKTLQVFKSETGEK--LLEIEAHDDEVLCCAFSADEKLLATCSADRKVKIW--------- 684

  Fly   688 RHSGGSKQQLVNSVVKRFIGSYANLKIVAFYLNEDAGLPEANIQLHV------AFINGDVSILNW 746
                                            |...|.|....:.|:      .|.||       
 Frog   685 --------------------------------NAKTGKPLRVYEEHIEQVNCCQFTNG------- 710

  Fly   747 DEQDQEFKLSHVPVLKTMQSGIRCFVQVLKRYYVVCTSNCTLTVWDL-TNGSSNTLELHVFNV-- 808
                    || .|:|.|                  |:::|.:.:|:. .|...|||..|:.:|  
 Frog   711 --------LS-APLLAT------------------CSNDCLIKLWNSEKNYCHNTLIGHIESVYH 748

  Fly   809 ----ENDTPLA-------LDVFDERS----KTATVLLIFKYSVWRLNFLPGLSVSLQSEAVQLPE 858
                .:|..||       |.::|..|    |:..|..:|                 ::|....||
 Frog   749 CRYSPDDRYLASSSMDGSLKIWDVESANEEKSIEVAKLF-----------------ENEDEAQPE 796

  Fly   859 GSFITCGKRSTDGRYLLLGTSEGLIVYDLKISDPVLRSNVSEHIE-CVDIYELFDPVYKYIVLCG 922
             ..:.|...|.||..:::.....|.:||.:      |.|:...:: |..|.        |...|.
 Frog   797 -VLLKCCAWSNDGSRIMVTARNFLCIYDAE------RCNLLSQLKACHQIL--------YCDFCT 846

  Fly   923 -------AKGKQVVHVHTLRS---VSGSNSHQNREIAWVH-------------SADEISVM---T 961
                   |....||.:..:.|   ::..|:|    ::|||             |:|:.:|.   |
 Frog   847 TNQIAALALSHYVVQLWDIDSSTKIADFNAH----LSWVHCVKFSPKSSSFLTSSDDQTVKLWET 907

  Fly   962 KACLEP-NVYLRSLMDMT--RERTQLLAVDSKERIHLIKPAISRISEWSTITPTHAASNCKINAI 1023
            ....:| ...|:...|:|  .|||.:||....:.|.||.....     .|::...|..|| :...
 Frog   908 SNVSKPAATNLKREFDVTFSGERTLVLATSKDDCILLINGMTG-----ETLSQIRAQDNC-VTCC 966

  Fly  1024 SAFNDEQI-FVGYVDG--VIID-----VIH------DTALPQQFIEE-----------PIDYLKQ 1063
            ....|.|: .:|:.||  .|:|     ::|      ||....||..:           .:.....
 Frog   967 CLSTDYQLAAIGHRDGKVKILDLSGGEILHKLDGHRDTVQHCQFTADGKLLVSSSDDCTVRVWNL 1031

  Fly  1064 VSPNILVASAHSAQKTVIFQLEKIDPLQPNDQWPLMMDVSTKYASLQEGQYIILFSDHGVCH--- 1125
            ||...|....|. :....|::     ||.:..:....|.:.|..:|..||.|..|    :||   
 Frog  1032 VSGKNLELCGHK-EPVKFFKI-----LQESKVFSWSFDGTVKVWNLLTGQLIKEF----ICHSAT 1086

  Fly  1126 ---LDIANPSAFVKPKDSEEYIVGFDLKNSLLFLAYENNIIDVFRLIFSCNQLRYEQICEEEIAQ 1187
               .||:..|.......:::....:.|.|..|.                 ::|...|.|    .:
 Frog  1087 VLACDISPDSTKFSSASTDKSAKIWSLDNCALL-----------------HELNKHQSC----VR 1130

  Fly  1188 KAKISYLVATDDGTMLAMGFENGTLELFAVENRKV------QLIYSIEEVHEHCIRQLLFSPCKL 1246
            ..:.|:     |...||.|.::|.:.:::|:|.::      ..:.:...:|:..:..|.|||...
 Frog  1131 CCRFSW-----DNQYLATGDDSGKIMIWSVQNGELLRECCDVSVNNENSLHDGWVTDLHFSPDNK 1190

  Fly  1247 LLISCAEQLCFWNVTHMRNNQLEREQKRRRSRRHKQHSVTQEDAVDAAPIAADIDVDVTFVADEF 1311
            |::|....:.:|                                          :||.......|
 Frog  1191 LIVSSGANIKWW------------------------------------------EVDTGACKQTF 1213

  Fly  1312 HPVNRGTAELWRNKRGNAIRPELLACVKFVGNEARQFFTDAHFSHFYAIDDEGVYYHLQLLE 1373
            :.                           :|...:.....:.|..|..||:.|:.|.|||:|
 Frog  1214 YT---------------------------IGTNLKSIHVCSIFRTFVTIDNLGILYVLQLIE 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DarkNP_725637.1 NB-ARC 133..390 CDD:279299 63/282 (22%)
apaf1XP_012815297.2 DD 7..92 CDD:417479 10/57 (18%)
NB-ARC 131..374 CDD:395745 58/255 (23%)
APAF1_C 453..587 CDD:407760 32/156 (21%)
WD40 610..906 CDD:238121 79/413 (19%)
WD40 repeat 619..655 CDD:293791 10/42 (24%)
WD40 repeat 660..697 CDD:293791 11/77 (14%)
WD40 repeat 703..741 CDD:293791 15/71 (21%)
WD40 repeat 746..788 CDD:293791 10/58 (17%)
WD40 repeat 800..875 CDD:293791 17/88 (19%)
WD40 871..1203 CDD:238121 78/419 (19%)
WD40 repeat 881..916 CDD:293791 7/34 (21%)
WD40 repeat 921..957 CDD:293791 11/40 (28%)
WD40 repeat 963..1000 CDD:293791 8/36 (22%)
WD40 repeat 1006..1041 CDD:293791 5/34 (15%)
WD40 repeat 1046..1080 CDD:293791 9/38 (24%)
WD40 repeat 1088..1123 CDD:293791 6/51 (12%)
WD40 repeat 1129..1170 CDD:293791 8/45 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11577
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D40665at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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