DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8963 and eif4g2b

DIOPT Version :9

Sequence 1:	NP_001163171.1	Gene:	CG8963 / 36913	FlyBaseID:	FBgn0034181	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001013461.2	Gene:	eif4g2b / 334618	ZFINID:	ZDB-GENE-030131-6550	Length:	898	Species:	Danio rerio

Alignment Length:	358	Identity:	74/358 - (20%)
Similarity:	136/358 - (37%)	Gaps:	107/358 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 PSTSTAAASSSSSNSSQPDMATIALEYLDTVIH----CLNQ-NPGQFDSIASRFLTIFDGMENNQ 305
            ||.||....:||:..          |:.|.:..    .||: .|.:||.:....|.:  |:: ::
Zfish    52 PSRSTRRDVNSSTEK----------EHHDAIFRKVRGILNKLTPEKFDKLCLELLNV--GVD-SK 103

  Fly   306 FVLSIAMEDIFEKSIEQPNFRYMGAKLYNLLHMLNSKPD---------------SLFHTLLKCKL 355
            .||...:..|.:|::|:|.:..:.|:|  .|.:....|:               :.|..||..||
Zfish   104 LVLKGIILLIVDKALEEPKYSSLYAQL--CLRLAEDAPNFDGPTPEIQSSQKQSTTFRRLLITKL 166

  Fly   356 DYHQEEVTKYM---------RSNEQQKVRETA--------LFLAELYMQLRGDDDSRIQLIAVNI 403
            ....|..||.:         .::|:::.|..|        .|:.||         .::.||..:|
Zfish   167 QDEFENRTKNVDLYDKQDNPLTSEEEEQRAIAKIKMLGNIKFIGEL---------GKLDLIHESI 222

  Fly   404 VYSLSKLL--------ASESNENVRCLCQTLKLAGYDLTADCPKDI-QEIITALQAI----ELKS 455
            ::...|.|        ..:..|::.||||.::..|..|..:..|.: .:....:|::    :|.:
Zfish   223 LHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHEKAKSLMDQYFGRMQSLMNNKDLPA 287

  Fly   456 PGKYPMAASVIALQQNNW---------GRKVSNALGDDEDTVKEPPRLSDEPVFYGPDGRELTAE 511
            ..:: :....:.|::|||         |.|..|.:  .:|.||      |..||..|..:.:..
Zfish   288 RIRF-LLQDTVELRENNWVPRKAFIDNGPKTINQI--RQDAVK------DLGVFIPPMNQGMRM- 342

  Fly   512 ETDFLAGGDNDGDDDFDGDGADLEIDAEMDEET 544
                          ||..:|..:....::|.||
Zfish   343 --------------DFFLEGPFMPNRMKLDRET 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8963	NP_001163171.1	MIF4G	270..472	CDD:214713	49/251 (20%)
eif4g2b	NP_001013461.2	MIF4G	73..303	CDD:280935	47/244 (19%)
		MA3	536..649	CDD:214714
		W2_eIF4G1_like	732..867	CDD:211397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910