DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8963 and eif4g2a

DIOPT Version :9

Sequence 1:	NP_001163171.1	Gene:	CG8963 / 36913	FlyBaseID:	FBgn0034181	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001014311.1	Gene:	eif4g2a / 323453	ZFINID:	ZDB-GENE-030131-2173	Length:	891	Species:	Danio rerio

Alignment Length:	325	Identity:	69/325 - (21%)
Similarity:	127/325 - (39%)	Gaps:	87/325 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 PSTSTAAASSSSSNSSQPDMATIALEYLDTVIHCLNQ-NPGQFDSIASRFLTIFDGMENNQFVLS 309
            ||.||....:||:...:.|      .....|...||: .|.:||.:....|.:  |:: ::.||.
Zfish    52 PSRSTRRDVNSSNEKERHD------AIFRKVRGILNKLTPEKFDKLCLELLNV--GVD-SKLVLK 107

  Fly   310 IAMEDIFEKSIEQPNFRYMGAKLYNLLHMLNSKPD---------------SLFHTLLKCKLDYHQ 359
            ..:..|.:|::|:|.:..:.|:|  .|.:....|:               :.|..||..||....
Zfish   108 GIILLIVDKALEEPKYSSLYAQL--CLRLAEDAPNFDGPSTEIQSSQKQSTTFRRLLISKLQDEF 170

  Fly   360 EEVTKYM---------RSNEQQKVRETA--------LFLAELYMQLRGDDDSRIQLIAVNIVYSL 407
            |..|:.:         .::|:::.|..|        .|:.||         .::.||..:|::..
Zfish   171 ENRTRNVDIYDKNDSPLTSEEEEQRAIAKIKMLGNIKFIGEL---------GKLDLIHESILHKC 226

  Fly   408 SKLL--------ASESNENVRCLCQTLKLAGYDLTADCPKDIQE-----IITALQAIELKSPGKY 459
            .|.|        ..:..|::.||||.::..|..|..:..|.:.:     :.:.:...:|.:..::
Zfish   227 IKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHEKAKSLMDQYFGRMRSLMNNKDLPARIRF 291

  Fly   460 PMAASVIALQQNNW---------GRKVSNALGDDEDTVKEPPRLSDEPVFYGPDGRELTAEETDF 515
             :....:.|::|||         |.|..|.:  .:|.||      |..||..|..:.:   .|||
Zfish   292 -LLQDTVELRENNWVPRKAFIDNGPKTINQI--RQDAVK------DLGVFIPPMTQGI---RTDF 344

Fly 516 515
Zfish 345 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8963	NP_001163171.1	MIF4G	270..472	CDD:214713	46/247 (19%)
eif4g2a	NP_001014311.1	MIF4G	73..303	CDD:280935	46/244 (19%)
		Med25_SD1	376..523	CDD:288132
		MA3	529..642	CDD:214714
		W2_eIF4G1_like	713..860	CDD:211397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910