DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8963 and Eif4g3

DIOPT Version :9

Sequence 1:	NP_001163171.1	Gene:	CG8963 / 36913	FlyBaseID:	FBgn0034181	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038965571.1	Gene:	Eif4g3 / 298573	RGDID:	1311370	Length:	1807	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	91/469 - (19%)
Similarity:	145/469 - (30%)	Gaps:	195/469 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 SSSSNSSQPDMATI-ALEYLDTVIHCLNQ-NPGQFDSIASRF--LTIFDGMENNQFVLSIAMEDI 315
            |...:|...|..:| ..|....|...||: .|..|:.:..:.  ||: |..|..:.|:.:    :
  Rat   950 SQKRDSHADDPESIKTQELFRKVRSILNKLTPQMFNQLMKQVSALTV-DTEERLKGVIDL----V 1009

  Fly   316 FEKSIEQPNFRYMGAKLYNLLHMLN----SKPDSL--FHTLL--KCKLDYHQ------------- 359
            |||:|::|:|....|.:...|..|.    .||.:.  |..||  :|:.::.:
  Rat  1010 FEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQK 1074

  Fly   360 --------EEVTKYMRSNEQ--QKVRETAL----FLAELYMQLRGDDDSRIQLIAVNIVYS-LSK 409
                    ||.|:.....|:  .|.|..::    |:.||:         :::::...|::. :.|
  Rat  1075 ELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELF---------KLKMLTEAIMHDCVVK 1130

  Fly   410 LLASESNENVRCLCQTLKLAGYDLTAD-------------------------------------- 436
            ||.:...|::.|||:.|...|.||..:
  Rat  1131 LLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRL 1195

  Fly   437 C----------PKDIQEI--------------ITALQAIELKSPG-------------------- 457
            |          ||.|::|              :..|...|.:.||
  Rat  1196 CNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRV 1260

  Fly   458 ----KY-----PMAASVIAL----QQNNWGRKVS-NALGDDEDTVK------------EPPRLSD 496
                |:     |.....|.|    |..:||:..| .|...:.|.::            :||..|.
  Rat  1261 LDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSPLQPPAPSG 1325

  Fly   497 EP-------------VFYGPDGREL--------TAEETDFLAGGDNDGDDDFDGDGADLEIDAEM 540
            .|             ...|..|||.        ||....||.|...|            .:|.:.
  Rat  1326 SPSATPLDFDSRRALTSRGSMGREKSDKPLPAGTARPNTFLRGSSKD------------LLDNQS 1378

  Fly   541 DEETERAYKEFCKQ 554
            .||..|...|..||
  Rat  1379 QEEQRREMLETVKQ 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8963	NP_001163171.1	MIF4G	270..472	CDD:214713	61/335 (18%)
Eif4g3	XP_038965571.1	PHA03247	<65..498	CDD:223021
		MIF4G	969..1197	CDD:397130	46/241 (19%)
		MA3	1435..1547	CDD:397128
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910