DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8963 and Paip1

DIOPT Version :9

Sequence 1:	NP_001163171.1	Gene:	CG8963 / 36913	FlyBaseID:	FBgn0034181	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_663432.1	Gene:	Paip1 / 218693	MGIID:	2384993	Length:	400	Species:	Mus musculus

Alignment Length:	409	Identity:	106/409 - (25%)
Similarity:	187/409 - (45%)	Gaps:	67/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 LNNSFQQIVQQTQHNQPQQPHHQQHNQQQQQYIQNQNQQPQPSTSTAAASSSSSNSSQ------- 262
            :::||.:..:||   :||:......::..||..::...:||...:....|..|:|:.:
Mouse     1 MSDSFDRAPEQT---KPQRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSANAPEFYPSGYS 62

  Fly   263 -----------PDMATIALEYLDTVIHCLNQNPGQFDSIASRFLTIFDGMENNQFVLSIAMEDIF 316
                       .|..|:: ||:...::.|.:.||.|::...:|....:|.......|...:|.|:
Mouse    63 SNYTESYEDGCEDYPTLS-EYVQDFLNHLTEQPGSFETEIEQFAETLNGWVTTDDALQELVELIY 126

  Fly   317 EKSIEQPNFRYMGAKLYNLL-HMLNSKPDS-LFHTLL--KCKLDYHQ-------EEVTKYMRSNE 370
            :::...|||.||||:|.|.| |.|...|.| .|..||  :|:.:|..       :|||:
Mouse   127 QQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEAKDQAAKGDEVTR------ 185

  Fly   371 QQKVRETALFLAELY--MQLRGDDD--SRIQLIAVNIVYSLSKLLASESNENVRCLCQTLKLAGY 431
             ::.....|||.|||  ::::|.:.  :|..::.|.:...|:.|.::..::|:.|..:.|||.|
Mouse   186 -KRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTG- 248

  Fly   432 DLTADCPK-----DIQEIITALQAIELK---SPGKYPMAASVIALQQNNWGRKVSNALGDDEDTV 488
            .:..|..|     |::|||..::.:.|.   |.....|...::.|:.:||||..:.:...:....
Mouse   249 SVLEDTWKEKGKTDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPE 313

  Fly   489 KEPPRLSDEPVFYGPDGRELTAEETDFLAGGD-----NDGDDDFDGDGADL---------EIDAE 539
            .:|....:||.||..||...||.:.|:.....     .|...|::.:|.||         :||.|
Mouse   314 NDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDE 378

  Fly   540 MDEETERAYKEFCKQGKQK 558
            ||.|.|.||::||.:.::|
Mouse   379 MDPEIEEAYEKFCLESERK 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8963	NP_001163171.1	MIF4G	270..472	CDD:214713	60/224 (27%)
Paip1	NP_663432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		8/37 (22%)
		PABPC1-interacting motif-2 (PAM2). /evidence=ECO:0000250	37..64		5/26 (19%)
		MIF4G	81..297	CDD:280935	60/223 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..376		4/19 (21%)
		PABPC1-interacting motif-1 (PAM1). /evidence=ECO:0000250	361..400		15/37 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849399
Domainoid	1	1.000	65	1.000	Domainoid score	I10028
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4709
Inparanoid	1	1.050	120	1.000	Inparanoid score	I4762
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto94950
orthoMCL	1	0.900	-	-		OOG6_108365
Panther	1	1.100	-	-	LDO	PTHR23254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5126
SonicParanoid	1	1.000	-	-		X5876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.920