DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8963 and PAIP1

DIOPT Version :9

Sequence 1:	NP_001163171.1	Gene:	CG8963 / 36913	FlyBaseID:	FBgn0034181	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_006442.2	Gene:	PAIP1 / 10605	HGNCID:	16945	Length:	479	Species:	Homo sapiens

Alignment Length:	527	Identity:	124/527 - (23%)
Similarity:	206/527 - (39%)	Gaps:	140/527 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 GAGGGAPYGQQQPRYVNGFKHHHQQHHQQPHYNHHHNHQQKFNNDMQKLTNSVQNRLHLNSQQGS 166
            |.|||.|.|...|   ||.....:..||.|                                |..
Human    20 GRGGGGPEGGGFP---NGAGPAERARHQPP--------------------------------QPK 49

  Fly   167 AGNYYQQQQVHQNTHHHQQHQQQHQPHNQHAKFQRHFHLNNSFQQIVQQTQHNQPQQPHHQQHNQ 231
            |..:.|...:.|.........|...|.:                          ||:|.......
Human    50 APGFLQPPPLRQPRTTPPPGAQCEVPAS--------------------------PQRPSRPGALP 88

  Fly   232 QQQQYIQ----NQNQQPQPSTSTAAA--------------------------SSSSSNSSQ---P 263
            :|.:.::    :|::.||.::.:|.|                          |||.:.|.:   .
Human    89 EQTRPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCE 153

  Fly   264 DMATIALEYLDTVIHCLNQNPGQFDSIASRFLTIFDGMENNQFVLSIAMEDIFEKSIEQPNFRYM 328
            |..|:: ||:...::.|.:.||.|::...:|....:|.......|...:|.|::::...|||.||
Human   154 DYPTLS-EYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYM 217

  Fly   329 GAKLYNLL-HMLNSKPDS-LFHTLL--KCKLDYH-------QEEVTKYMRSNEQQKVRETALFLA 382
            ||:|.|.| |.|...|.| .|..||  :|:.:|.       .:|||:       ::.....|||.
Human   218 GARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTR-------KRFHAFVLFLG 275

  Fly   383 ELY--MQLRGDDD--SRIQLIAVNIVYSLSKLLASESNENVRCLCQTLKLAGYDLTADCPK---- 439
            |||  ::::|.:.  :|..::.|.:...|:.|.::..::|:.|..:.|||.| .:..|..|
Human   276 ELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTG-SVLEDAWKEKGK 339

  Fly   440 -DIQEIITALQAIELK---SPGKYPMAASVIALQQNNWGRKVSNALGDDEDTVKEPPRLSDEPVF 500
             |::|||..::.:.|.   |.....|...::.|:.:||||..:.:...:.....:|....:||.|
Human   340 MDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTF 404

  Fly   501 YGPDGRELTAEETDFLAGGD-----NDGDDDFDGDGADL---------EIDAEMDEETERAYKEF 551
            |..||...||.:.|:.....     .|...|::.:|.||         :||.|||.|.|.||::|
Human   405 YTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKF 469

  Fly   552 CKQGKQK 558
            |.:.::|
Human   470 CLESERK 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8963	NP_001163171.1	MIF4G	270..472	CDD:214713	60/224 (27%)
PAIP1	NP_006442.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		26/154 (17%)
		PRK14951	<35..>123	CDD:237865	18/145 (12%)
		PABPC1-interacting motif-2 (PAM2)	116..143		1/26 (4%)
		MIF4G	160..376	CDD:397130	60/223 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..455		4/19 (21%)
		PABPC1-interacting motif-1 (PAM1)	440..479		15/37 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159017
Domainoid	1	1.000	64	1.000	Domainoid score	I10200
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4709
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4843
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91371
orthoMCL	1	0.900	-	-		OOG6_108365
Panther	1	1.100	-	-	LDO	PTHR23254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5126
SonicParanoid	1	1.000	-	-		X5876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.920