DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and ACTN3

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001245300.2	Gene:	ACTN3 / 89	HGNCID:	165	Length:	944	Species:	Homo sapiens

Alignment Length:	778	Identity:	171/778 - (21%)
Similarity:	290/778 - (37%)	Gaps:	206/778 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|:|..:|..:..|:|:         |.:..:.||.||:..|..|.||.|.|..|||
Human   166 SIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSW 230

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:|.||:||...|:|||.:||...|.:||....|:.||. |.||::::..|:.....||:.|:
Human   231 KDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAI 295

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQNRINFSHPKSLLLHQNSFDEEIN 616
            |||:......|.|    .||..:.|:....|:.           :|..:.|.:..::....|.:.
Human   296 MTYVSCFYHAFAG----AEQAETAANRICKVLA-----------VNQENEKLMEEYEKLASELLE 345

  Fly   617 GSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSCQTTPPQDESL 681
            ...::...       ::|.:...|.:.:.:.|...:|...::......:...|.......|.: |
Human   346 WIRRTVPW-------LENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTK-L 402

  Fly   682 DKGSQPG-----GKENSSITTIDPQAASEERQQRLLEQARR-----LILETRVKSGGSIESPTRP 736
            ....:|.     ||..|.|.          ...|.|||..:     |:.|.|
Human   403 RLSHRPAFMPSEGKLVSDIA----------NAWRGLEQVEKGYEDWLLSEIR------------- 444

  Fly   737 KLERTISPIHNGAEEFYAEHAKKLELKEPGSP------SHRLSDPKVLQSFNAIVERVSPKHEK- 794
            :|:|    :.:.||:|    .:|..|.|..:.      |.|..|..:||...|::.|    ||.
Human   445 RLQR----LQHLAEKF----RQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRR----HEAF 497

  Fly   795 RGDKLSYID--SELEALEREQEAID-QKASNLEAKLRAVMG-----GNPSNNRRGG--------- 842
            ..|..::.|  ..:.||.:|...:| .:|:::.::.:|:..     |..:..||..
Human   498 ESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLE 562

  Fly   843 ---------ARNSNPFLRLIRNSIGGG--DVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDR 896
                     ||.:.||    .|.:.|.  |:..:.|:.|.:|
Human   563 TIDRLQLEFARRAAPF----NNWLDGAVEDLQDVWLVHSVEE----------------------- 600

  Fly   897 DTSSDSVCNSGDELHTRLRPRPRSHSCFVN-KNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSA 960
               :.|:..:.|:....|....|.....:. :.....|.....|||...:   ||   :..||..
Human   601 ---TQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTN---PY---ITLSPQD 656

  Fly   961 LSSQQSSCDNL-PACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTP-NHCETEE 1023
            ::::......| |:|   |:.|       ...|.|||...|.|||...:.:.:  .| ...:.||
Human   657 INTKWDMVRKLVPSC---DQTL-------QEELARQQVNERLRRQFAAQANAI--GPWIQAKVEE 709

  Fly  1024 T-----------EEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLER---KYTMLNQELRAAQS 1074
            .           |||:            |.||:|.| ||:..:.:::|   .:.:|.:.|
Human   710 VGRLAAGLAGSLEEQM------------AGLRQQEQ-NIINYKTNIDRLEGDHQLLQESL----- 756

  Fly  1075 VEDWRKTEVQREKERLLLEELMTIVDKRDQLVQHLHNQEI-----AIEDDQ--EIARKLEHVD 1130
            |.|.:.|....|..|:..|:|:|.:.:   .:..:.||.:     .:..:|  |......|.|
Human   757 VFDNKHTVYSMEHIRVGWEQLLTSIAR---TINEVENQVLTRDAKGLSQEQLNEFRASFNHFD 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	41/102 (40%)
		DUF3585	<1027..1122	CDD:288945	22/104 (21%)
ACTN3	NP_001245300.2	CH	90..187	CDD:278723	6/20 (30%)
		CH	202..307	CDD:237981	41/104 (39%)
		Spectrin	331..440	CDD:278843	18/126 (14%)
		SPEC	452..679	CDD:238103	53/280 (19%)
		SPEC	570..790	CDD:238103	59/288 (20%)
		EFh	807..869	CDD:238008	3/10 (30%)
		EF-hand_7	809..868	CDD:290234	2/8 (25%)
		EFhand_Ca_insen	874..940	CDD:285885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810