DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ehbp1 and ACTN2

DIOPT Version :9

Sequence 1:NP_995865.2 Gene:Ehbp1 / 36912 FlyBaseID:FBgn0034180 Length:1141 Species:Drosophila melanogaster
Sequence 2:NP_001094.1 Gene:ACTN2 / 88 HGNCID:164 Length:894 Species:Homo sapiens


Alignment Length:801 Identity:164/801 - (20%)
Similarity:285/801 - (35%) Gaps:289/801 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|::..:|..:..|:|:         |.:..:.||.||:..|..|.||.:.|..|||
Human   116 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:..||:||...|:|||.|||:..|.:||..:..:.||. |.||::::..|:.....||:.|:
Human   181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAI 245

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIG-DYKSDNLSQNRINFSHPKSLLLH-------- 607
            |||:......|.|    .||..:.|:....|:. :.:::.|.:   .:....|.||.        
Human   246 MTYVSCFYHAFAG----AEQAETAANRICKVLAVNQENERLME---EYERLASELLEWIRRTIPW 303

  Fly   608 -QNSFDEEINGSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSC 671
             :|...|      |:.|......:|.::   |..|:...||....:.:.:.|..|     ..|..
Human   304 LENRTPE------KTMQAMQKKLEDFRD---YRRKHKPPKVQEKCQLEINFNTLQ-----TKLRI 354

  Fly   672 QTTP---PQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARR-----LILETRVKSGG 728
            ...|   |.:          ||..|.|      |.:.:|    ||||.:     |:.|.|     
Human   355 SNRPAFMPSE----------GKMVSDI------AGAWQR----LEQAEKGYEEWLLNEIR----- 394

  Fly   729 SIESPTRPKLERTISPIHNGAEEFYAE--------HAKKLELKEPGSPSHRLSDPKVLQSFNAIV 785
                    :|||    :.:.||:|..:        :.|:..|.:....|..|::.:.|...:...
Human   395 --------RLER----LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAF 447

  Fly   786 ERVSPKHEKRGDKLSYIDSEL---------------------------------EALEREQ---E 814
            |.....|:.|.::::.|..||                                 |||||.:   |
Human   448 ESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLE 512

  Fly   815 AIDQKASNLEAKLRAVMGGNPSNNRRGGARNSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGG 879
            .|||  .:||...||.    |.||...||.                         .|.:.:|   
Human   513 TIDQ--LHLEFAKRAA----PFNNWMEGAM-------------------------EDLQDMF--- 543

  Fly   880 AGSGGGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHV 944
                                   :.:|.:|:.:.:    .:|..|     ::|:           
Human   544 -----------------------IVHSIEEIQSLI----TAHEQF-----KATL----------- 565

  Fly   945 HHVVPYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERR 1009
                         |.|...:||    :.|..::.|.:..:.|.|.:|                  
Human   566 -------------PEADGERQS----IMAIQNEVEKVIQSYNIRISS------------------ 595

  Fly  1010 SHLCHTPNHCETEETEEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELR---A 1071
                   ::..:..|.::|.::|..:  |:...:|.|      ..:::|.|::.  |:.||   |
Human   596 -------SNPYSTVTMDELRTKWDKV--KQLVPIRDQ------SLQEELARQHA--NERLRRQFA 643

  Fly  1072 AQ--SVEDWRKTEVQREKERLLLEELM---TIVDKRDQLVQHLHN------------------QE 1113
            ||  ::..|    :|.:.|.:....:.   .:.|:.:||.|:.||                  ||
Human   644 AQANAIGPW----IQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQE 704

  Fly  1114 IAIEDDQEIARKLEHVDISAE 1134
            ..:.|::.....:||:.:..|
Human   705 ALVFDNKHTNYTMEHIRVGWE 725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ehbp1NP_995865.2 NT-C2 12..165 CDD:287345
CH 460..562 CDD:237981 39/102 (38%)
DUF3585 <1027..1122 CDD:288945 25/120 (21%)
ACTN2NP_001094.1 Actin-binding 1..254 47/137 (34%)
SAC6 36..>299 CDD:227401 57/189 (30%)
Spectrin 1 281..391 29/146 (20%)
Spectrin 281..391 CDD:306853 29/146 (20%)
Spectrin 2 401..506 17/104 (16%)
SPEC 402..629 CDD:238103 54/353 (15%)
Spectrin 3 516..627 32/237 (14%)
Spectrin 4 637..740 20/93 (22%)
Spectrin 637..739 CDD:306853 20/93 (22%)
EFh_PEF 747..>851 CDD:330173
EFhand_Ca_insen 824..890 CDD:312305
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0035
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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