DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and Sptbn4

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	XP_006540500.1	Gene:	Sptbn4 / 80297	MGIID:	1890574	Length:	2580	Species:	Mus musculus

Alignment Length:	895	Identity:	181/895 - (20%)
Similarity:	295/895 - (32%)	Gaps:	333/895 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 ESIGSCFSTSGSLNNSLKPVEKIVL--------------KENTPGQD-LLEWCKEVTKDYPNVKV 480
            |::||.....|:...:|..|..|:|              :|....:| ||.||:..|..||.|.:
Mouse   158 ENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNI 222

  Fly   481 TNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLT 544
            .|.|||||:|:||.|:||...|:|:|:|||:..:...|.:..|..||. ||:.|:::|.|:|| .
Mouse   223 QNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNM-E 286

  Fly   545 VPDKLAVMTYLHQLRAHFTG-KQLKIE--QIGSTAD---ESSYVIGDYKSDNLSQNRINFSHPKS 603
            .||:.:::||:.....:|:. |.|.:|  :||...|   |...:|..|  :.|:...:.:.|...
Mouse   287 APDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERY--EELAAELLAWIHRTV 349

  Fly   604 LLLHQNSFDEEINGSNKSEQLSP---TSKKDVKNLILYNSKNILDKVLSPTKDK----------- 654
            .|:....|...::|..:..|...   |.:|.||    :..|..|:.:|...:.|
Mouse   350 DLISNQKFANSLSGVQQQLQAFTAYCTLEKPVK----FQEKGNLEVLLFSIQSKLRAHNRRLFVP 410

  Fly   655 -------------NSINASQHANQSPMLSCQTTPPQDESLDKGSQPGG----------KENSSIT 696
                         ..:..::|..::.:   :....:.|.|:..:|...          .||..:.
Mouse   411 REGCGIWDIDKAWGELEKAEHEREAAL---RAELIRQEKLELLAQRFDHKVAMRESWLNENQRLV 472

  Fly   697 TID------PQ---------------AASEERQQRLLEQARRLILE-----TRVKSG-------- 727
            :.|      |.               ||.|||.|.:.|.|:.|..|     .||.:.
Mouse   473 SQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQW 537

  Fly   728 ---GSIESPTRPKLERTIS--------------------------------------PIHNGAEE 751
               ..:....|.:||:.::                                      ..|...|.
Mouse   538 ALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEG 602

  Fly   752 FYAEHAKKLE------LKEPGSPSHRLSDPKVLQSFNAIVERVSPKH-------EKRGDKLSYID 803
            ..|..::::|      |:......::..||:|      |..||:..|       |:...:.:.::
Mouse   603 DIAAQSERVEALNAAALRFSQLQGYQPCDPQV------ICNRVNHVHGCLSELQEQAARRRAELE 661

  Fly   804 S--ELEALEREQEAIDQKASNLEAKLRAVMGGNPSNNRRGGARNSNPFLRL------IRNSIGGG 860
            :  .|.||.:|.|..:..|.:.|..|.|..|...:....|||.:.:...||      ::..:||.
Mouse   662 ASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGR 726

  Fly   861 DVIRIKLLDSDDE-SLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCF 924
            ..:..:.|...:| :..||..|.|.
Mouse   727 RALLQQALRRGEELAAAGGSVGPGA---------------------------------------- 751

  Fly   925 VNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRA 989
                      .|.||                   :.|:.                        ||
Mouse   752 ----------EPLHL-------------------AGLAE------------------------RA 763

  Fly   990 ASLRRQQDRHRRRRQRRERR------------------------SHLCHTPNHCETEETEEQLLS 1030
            ||.||:..|......|||||                        ..|....:....|.:..:|..
Mouse   764 ASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLAR 828

  Fly  1031 QWFTLVNKKNAL------LRRQ----------------MQLNILEQEK---DLERKYTMLNQELR 1070
            |...|..:..|.      ||||                :|:.::|.|:   ::.....:..|.||
Mouse   829 QHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLR 893

  Fly  1071 AAQSV----------EDWRKTEVQREKERLLLEELMTIVDKRD--QLVQH 1108
            .|.:|          |.|     ..|||:.||  .|.:.|..|  ::|||
Mouse   894 DALAVYRMFGEVHACELW-----IGEKEQWLL--AMRVPDSLDDVEVVQH 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	42/103 (41%)
		DUF3585	<1027..1122	CDD:288945	29/119 (24%)
Sptbn4	XP_006540500.1	SAC6	75..>423	CDD:227401	75/271 (28%)
		SPEC	450..664	CDD:238103	33/219 (15%)
		SPEC	790..1002	CDD:238103	31/154 (20%)
		SPEC	1106..1210	CDD:197544
		SPEC	1216..1424	CDD:238103
		SPEC	1322..1529	CDD:238103
		SPEC	1531..1742	CDD:238103
		SPEC	1637..1849	CDD:238103
		Spectrin	1849..1948	CDD:334073
		SPEC	1958..>2125	CDD:238103
		PH_beta_spectrin	2437..2541	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910