DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and Specc1l

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001139298.1	Gene:	Specc1l / 74392	MGIID:	1921642	Length:	1135	Species:	Mus musculus

Alignment Length:	695	Identity:	146/695 - (21%)
Similarity:	238/695 - (34%)	Gaps:	258/695 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 DNHTISVTL---FKDPRTHELEDK------DWTFVIEDVTPMGKKRVLANASINMRKYASIESTQ 131
            |.|.||..:   .|..|..|||.:      :..|..|.:  :|.::.|:| ::.|.:..:.|:
Mouse   489 DEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQL--LGVQQHLSN-TLKMAEQDNKEA-- 548

  Fly   132 QSFTLSLKPVS-------------KKITAASLELTISCVFLREGKAT---------------DED 168
            |....:||..|             |...||:||         |.|||               :.:
Mouse   549 QEMIGALKERSHHMERIIESEQKGKAALAATLE---------EYKATVASDQIEMNRLKAQLENE 604

  Fly   169 MQSVVSMMSVNNNDVAPLDDLEDIPDL---------------------------------DGFSE 200
            .|.|..:.|::|:     .|..||.||                                 |..::
Mouse   605 KQKVAELYSIHNS-----GDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDTIAK 664

  Fly   201 ITDNFNDFTQQLEHMTTSLNGCIDVATPQSVPSLSEDPTPLAESFNPLHFELDADGKREAANKL- 264
            :.|.:..|.::.:.....||..::....:    |.|..|..::....: |||:.:.::..|.||
Mouse   665 VEDEYRAFQEEAKKQIEDLNMTLEKLRSE----LEEKDTERSDMKETI-FELEDEVEQHRAVKLH 724

  Fly   265 ---------------------------------------------DLPTA---ASGGSSGAEESL 281
                                                         ||.||   |:...|.|:|.:
Mouse   725 DNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEI 789

  Fly   282 KTPNGLQHVV---DQTPIKSPDEVKQPKQ-----------TPVE------------SLRSKTNED 320
            .......|..   ::...|..:|:|..||           ..||            |.||.|:.:
Mouse   790 GDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSE 854

  Fly   321 -----------FDK----------MVTSTPLEPNVNKDD----VKPKKKRAL---FFTEKE---- 353
                       ||.          .:..|||.|:..|..    |.|.::.::   ..|.|.
Mouse   855 PTPTVKTLIKSFDSASQVPNAAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTAL 919

  Fly   354 ------------DEQDLRVESVKE----------DTTKTIGDNSTTKEKPKEESQSSKDAS--SV 394
                        .|..||..|...          ::.|||..:..:.|:.|.:..:|:.||  |:
Mouse   920 SDKRSNYGELPVQEHLLRTSSTSRPASLPRVPAMESAKTISVSRRSSEEMKRDISASEGASPASL 984

  Fly   395 VVPSAKRPELQPLNLKKSYEPSQTP-------ESAPVPASVINESIGSCFSTSGSLNNSLKPVEK 452
            :......|:   |:|..|...|.||       |....|.|.:....|      ||..|:
Mouse   985 MAMGTTSPQ---LSLSSSPTASVTPSTRSRIREERKDPLSALAREYG------GSKRNA------ 1034

  Fly   453 IVLKENTPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVG 517
                       ||:||::.|:.|.|:.:||.::||.:|:||||::|.::|..|...:|::.|...
Mouse  1035 -----------LLKWCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKKR 1088

  Fly   518 NCRIGFDAAESLGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHF 562
            |..:.|.||||:||...::..:|.....||...||.|:..:..:|
Mouse  1089 NFTLAFQAAESVGIKSTLDINEMARTERPDWQNVMLYVTAIYKYF 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	27/110 (25%)
		CH	460..562	CDD:237981	35/101 (35%)
		DUF3585	<1027..1122	CDD:288945
Specc1l	NP_001139298.1	SMC_prok_B	219..>843	CDD:274008	68/377 (18%)
		Smc	<518..819	CDD:224117	56/324 (17%)
		SLAIN	<839..980	CDD:373728	25/140 (18%)
		CH	1033..1133	CDD:237981	36/116 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000