DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and Actn4

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	XP_008757407.1	Gene:	Actn4 / 63836	RGDID:	61816	Length:	933	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	156/780 - (20%)
Similarity:	275/780 - (35%)	Gaps:	245/780 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|:...:|..:..|:|:         |.:..:.||.||:..|..|.||.|.|...||
  Rat   128 SIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISW 192

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:||.|:||...||||:..||...|.|.|....|:.||. |.||::::..|:.....||:.|:
  Rat   193 KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAI 257

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQNRINFSHPKSLLLHQNSFDEEIN 616
            |||:                                                     :||....:
  Rat   258 MTYV-----------------------------------------------------SSFYHAFS 269

  Fly   617 GSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSC--QTTPPQDE 679
            |:.|:|                .:.|.:.|||:..::...:........|.:|..  :|.|..::
  Rat   270 GAQKAE----------------TAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLED 318

  Fly   680 SLDKGSQPGGKENSSITTIDPQAASEERQQRL--LEQARRLILETRVKSGGSIE---SPTRPKLE 739
            .:                  ||...:|.||:|  ....||:....:|:....:|   :..:.||.
  Rat   319 RV------------------PQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLR 365

  Fly   740 ------------RTISPIHNGAEEFYAEHAKKLELKEPGSPSHRLSDPKVLQSFNAIVERVSPK- 791
                        |.:|.|:||.:.        ||..|.|.....|::.:.|:..:.:.|:...|
  Rat   366 LSNRPAFMPSEGRMVSDINNGWQH--------LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKA 422

  Fly   792 --HEKRGD----KLSYID------SELEALEREQEAIDQKASNLEA------KLRAVMGGNPSNN 838
              ||...|    .|.:.|      |:::||.|:.||.:   |:|.|      ::.|:
  Rat   423 SIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFE---SDLAAHQDRVEQIAAI-------- 476

  Fly   839 RRGGARNSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSV 903
                |:..|.                   ||..|                    ..:.:|....:
  Rat   477 ----AQELNE-------------------LDYYD--------------------SHNVNTRCQKI 498

  Fly   904 CNSGDEL----HTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSALSSQ 964
            |:..|.|    |:|.....::         :..:.|...|...:.....|:.:.::|:...|.
  Rat   499 CDQWDNLGSLTHSRREALEKT---------EKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQ-- 552

  Fly   965 QSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHR-------RRRQRRERRSHLCHTPNHCETE 1022
                |.....:.::....::|:.:..|.....||.|       :..||....:|:..:.::..|.
  Rat   553 ----DMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTS 613

  Fly  1023 ETEEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQR-- 1085
            .|.:.:.|:|    .|...|:.::....:.||.|....:: :..|....|..|..|.:|:::.
  Rat   614 VTPQIINSKW----EKVQQLVPKRDHALLEEQSKQQSNEH-LRRQFASQANMVGPWIQTKMEEIG 673

  Fly  1086 ----EKERLLLEEL-------MTIVDKRDQL----VQHLHNQEIAIEDDQEIARKLEHVDISAEK 1135
                |....|.::|       .:|||.:..|    .||...||..|.|::.....:||:.:..|:
  Rat   674 RISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHLRVGWEQ 738

Fly 1136 1135
Rat 739 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	40/102 (39%)
		DUF3585	<1027..1122	CDD:288945	25/111 (23%)
Actn4	XP_008757407.1	CH	51..149	CDD:278723	5/20 (25%)
		CH	164..268	CDD:237981	42/156 (27%)
		SPEC	296..517	CDD:238103	55/300 (18%)
		SPEC	414..640	CDD:238103	48/298 (16%)
		SPEC	532..754	CDD:238103	42/218 (19%)
		EFh	769..858	CDD:238008
		EFhand_Ca_insen	863..929	CDD:285885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810