DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and SPTBN4

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_066022.2	Gene:	SPTBN4 / 57731	HGNCID:	14896	Length:	2564	Species:	Homo sapiens

Alignment Length:	888	Identity:	181/888 - (20%)
Similarity:	290/888 - (32%)	Gaps:	314/888 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 ESIGSCFSTSGSLNNSLKPVEKIVL--------------KENTPGQD-LLEWCKEVTKDYPNVKV 480
            |::||.....|:...:|..|..|:|              :|....:| ||.||:..|..||.|.:
Human   138 ENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNI 202

  Fly   481 TNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLT 544
            .|.|||||:|:||.|:||...|:|:|.|||:..:...|.:..|..||. ||:.|:::|.|:|| .
Human   203 QNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNM-E 266

  Fly   545 VPDKLAVMTYLHQLRAHFTG-KQLKIE--QIGSTAD---ESSYVIGDYKSDNLSQNRINFSHPKS 603
            .||:.:::||:.....:|:. |.|.:|  :||...|   |...:|..|  :.|:...:.:.|...
Human   267 APDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERY--EELAAELLAWIHRTV 329

  Fly   604 LLLHQNSFDEEINGSNKSEQLSP---TSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQ 665
            .|:....|...::|..:..|...   |.:|.||                 .::|.::.....:.|
Human   330 GLISNQKFANSLSGVQQQLQAFTAYCTLEKPVK-----------------FQEKGNLEVLLFSIQ 377

  Fly   666 SPMLSCQT---TPPQDESLDKGSQPGGKENSSITTIDP-----QAASEERQQRL----------- 711
            |.:.:|..   .|              :|...|..||.     :.|..||:..|
Human   378 SKLRACNRRLFVP--------------REGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLE 428

  Fly   712 ----------------LEQARRLI-----------LETRVKSGGSIESPTRPKLERTISPIHNGA 749
                            |.:.:||:           :|..:|...:||:......|| :..:...|
Human   429 LLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEER-VQGVAELA 492

  Fly   750 EEFYAE--------------------------HAKKLELKEPGSPSHRLSDPKVLQSFNAIVE-- 786
            :...||                          .|::..|::      .|:..||.|....:|:
Human   493 QALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQ------NLALQKVFQEMVYMVDWM 551

  Fly   787 ---------RVSPKHEKRGDKL----SYIDSELEALEREQEAIDQKASNLEAKLRAVMGGNPSN- 837
                     |...:|....|.|    ..::.::.|.....||::..|    .:...:.|..|.:
Human   552 EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAA----LRFSQLQGYQPCDP 612

  Fly   838 ----------------------NRRGGARNSNPFLRLIRNSIGGGDVIRIK--LLDSDDESLFGG 878
                                  .||.....|.....|::.........|.|  ||    |:..||
Human   613 QVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL----EAAGGG 673

  Fly   879 GAGSGGGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHH 943
            ||....|.:|......|                                     :::.|.|...|
Human   674 GAAGAAGAAGTAGGAHD-------------------------------------LSSTARLLAQH 701

  Fly   944 VHHVVPYTHMLDSSPSALSSQQSSCDNLPACSDD------------DEVLAVAANGRAASLRRQQ 996
                    .:|...   |..:::.......|.::            |.|..|....||||.||:.
Human   702 --------KILQGE---LGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRW 755

  Fly   997 DRHRRRRQRRERR------------------------SHLCHTPNHCETEETEEQLLSQWFTLVN 1037
            .|......|||||                        ..|....:....|.:..:|..|...|..
Human   756 QRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTG 820

  Fly  1038 KKNAL------LRRQ----------------MQLNILEQEK---DLERKYTMLNQELRAAQSV-- 1075
            :..|.      ||||                :|:.::|.|:   ::.....:..|.||.|.:|
Human   821 EVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYR 885

  Fly  1076 --------EDWRKTEVQREKERLLLEELMTIVDKRD--QLVQH 1108
                    |.|     ..|||:.||.  |.:.|..|  ::|||
Human   886 MFGEVHACELW-----IGEKEQWLLS--MRVPDSLDDVEVVQH 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	42/103 (41%)
		DUF3585	<1027..1122	CDD:288945	29/119 (24%)
SPTBN4	NP_066022.2	Actin-binding	1..282		51/144 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		CH	62..165	CDD:237981	8/26 (31%)
		CH	181..284	CDD:237981	42/103 (41%)
		SPEC	311..419	CDD:295325	25/140 (18%)
		Spectrin 1. /evidence=ECO:0000255	311..418		24/139 (17%)
		SPEC	430..644	CDD:238103	31/224 (14%)
		Spectrin 2. /evidence=ECO:0000255	430..533		14/103 (14%)
		Spectrin 3. /evidence=ECO:0000255	536..641		16/108 (15%)
		Spectrin 4. /evidence=ECO:0000255	774..879		15/104 (14%)
		SPEC	775..987	CDD:238103	31/154 (20%)
		Spectrin 5. /evidence=ECO:0000255	884..982		13/45 (29%)
		Spectrin 6. /evidence=ECO:0000255	1089..1196
		SPEC	1091..1195	CDD:197544
		SPEC	1201..1409	CDD:238103
		SPEC	1306..1514	CDD:238103
		Spectrin 7. /evidence=ECO:0000255	1306..1407
		Spectrin 8. /evidence=ECO:0000255	1412..1512
		Spectrin 9. /evidence=ECO:0000255	1515..1617
		SPEC	1516..1727	CDD:238103
		SPEC	1622..1834	CDD:238103
		Spectrin 10. /evidence=ECO:0000255	1623..1725
		Spectrin 11. /evidence=ECO:0000255	1728..1830
		Spectrin	1834..1933	CDD:278843
		Spectrin 12. /evidence=ECO:0000255	1835..1935
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1853..1872
		SPEC	1943..>2110	CDD:238103
		Spectrin 13. /evidence=ECO:0000255	1944..2046
		Spectrin 14. /evidence=ECO:0000255	2049..2123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2208..2439
		PH	2419..2527	CDD:278594
		PH_beta_spectrin	2421..2525	CDD:269975
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2533..2564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910