DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and micall2b

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001299826.1	Gene:	micall2b / 556298	ZFINID:	ZDB-GENE-030131-5803	Length:	783	Species:	Danio rerio

Alignment Length:	807	Identity:	175/807 - (21%)
Similarity:	319/807 - (39%)	Gaps:	182/807 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 LLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAE- 527
            |.:|||...:.|.:|.:||:|||:|:|:||||:||...|:|||...||..::..|.:..|:.||
Zfish     7 LQQWCKIQCEGYRDVSITNMTTSFRDGLAFCALIHKHRPDLIDFDSLSKENIYENNQRAFEVAEK 71

  Fly   528 SLGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHFTGKQLKIEQIGS---TADESSYVIGDYKSD 589
            .||||.:::..||..|.|||:|:::||:.|...:|.|:. .|..:|.   .|:||:......|:.
Zfish    72 ELGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRS-PIGGMGGIKRPAEESNEAPSGKKNP 135

  Fly   590 NLSQNRINFSHPKSLLLHQNSFDEEINGSNKSEQL--------SPTSKKDV---------KNLI- 636
            .:....:....|.:    :|...:..| .||.|.|        :|:|...|         ::|:
Zfish   136 PVIAKVLPSPKPAT----ENKTPKPAN-ENKREVLTERANKSSTPSSNCSVCNQHVHLVQRHLVD 195

  Fly   637 --LYN---------SKNILDKVLSPTKDKNSINASQHAN-QSPMLSCQTTPPQDESL-----DKG 684
              ||:         |..:|.......|:..:.....|.: :.|:.:..|.|.:.:|.     |:.
Zfish   196 GKLYHRNCFKCKECSTILLSGTYKAGKEPGTFICKTHTSIEKPLTTRFTAPSKTQSTFINKPDQS 260

  Fly   685 SQPGGKENSSITTIDPQAASEERQQRLLEQARRLILE------------------TRVKSGGSIE 731
            :..|....:|:.|      :..:...|..::.|:.:.                  |......:.:
Zfish   261 ALGGSTGKASLNT------NTSKLGWLANKSDRIPMRGFTDTPTPAVQLTPTAKATPTPDTTTAK 319

  Fly   732 SPTRPK-LERTISPIHNGAEEFYAEHAKKLELKEPGSPSHRLSDPKVLQSFNAIVE--------- 786
            ||:.|: ...::.|:.|..::......:..| ....|||..:...|...|:.:...
Zfish   320 SPSGPRSATESLKPVSNTVQKNQEARMRFFE-SSSSSPSSVVPASKSTSSYTSTTSVSTAGVKTT 383

  Fly   787 -------RVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMG--------GNPS 836
                   || |....:|..|..:....::.:.|:|..::|.   :.|.:||:|        .|.|
Zfish   384 APETTTPRV-PAGAGKGRVLLRVGDWAKSQDTEKEKENEKE---KEKAKAVIGKMVKVDKDSNSS 444

  Fly   837 NNRRGGAR-NSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTS- 899
            :....|.: ||:....|..|:......:|:|.|::..|:...........:..:.|.:.:..:|
Zfish   445 SASPAGLKANSSNVPPLESNAKAPFGRVRLKALEASGETTAPATTVPSWMKEKSLSRNVNTPSSN 509

  Fly   900 ---SDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSAL 961
               :|:|   ..:..:.|:|..:..|...:|      ..||. |...|..  |.|.:..||.:.:
Zfish   510 SKENDTV---PSDWRSMLKPVSKPVSNLESK------GLPAR-RTEAVSS--PKTSVPASSTTTI 562

  Fly   962 SSQQSS--------CDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNH 1018
            |...||        ..|....:|...|..|:.:|                    ..:|..|.|.:
Zfish   563 SISISSSKTPLTTPLKNGSKPNDSSSVFPVSPSG--------------------TETHKSHKPGY 607

  Fly  1019 ---------------------------------CETEETEEQLLS----QWFTLVNKKNALLRRQ 1046
                                             |:.:..|:.|::    .||||:..|...:||:
Zfish   608 IPKEDIQKELKEIEMNMNELEKKGVELEKQLRQCDEDGEEDALMNDLMVDWFTLIRNKQVYMRRE 672

  Fly  1047 MQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKERLLLEELMTIVDKRDQLVQHLHN 1111
            .:|..:.:.:|||.:...::.|||......|..||...|::|..|:.:|:.||:.|:.:|:.|..
Zfish   673 SELVYIARTQDLEEEQPSVDAELRRLMEKPDHLKTLWDRKREEELMAKLVEIVNDRNAIVEGLDE 737

  Fly  1112 QEI-AIEDDQEIARKLEHVDISAEKDK 1137
            ..: ..|:|:::.:.::..|:..||.|
Zfish   738 DRLREEEEDEQLNKMMQSFDMKKEKVK 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	43/98 (44%)
		DUF3585	<1027..1122	CDD:288945	29/99 (29%)
micall2b	NP_001299826.1	CH	5..102	CDD:278723	42/94 (45%)
		LIM_Mical_like_1	179..233	CDD:188828	7/53 (13%)
		DUF3585	609..741	CDD:288945	29/131 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583252
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840