DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and specc1lb

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	XP_021324703.1	Gene:	specc1lb / 555467	ZFINID:	ZDB-GENE-090423-1	Length:	1146	Species:	Danio rerio

Alignment Length:	519	Identity:	116/519 - (22%)
Similarity:	213/519 - (41%)	Gaps:	119/519 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ELEDKD--------WTFVIED------VTPMGKKRVLANASINMRKYASIESTQQSFTLSLKPVS 142
            |||:||        ..|.:||      ...:....::::...:::|   :...:......:|.:.
Zfish   697 ELEEKDTEIADMKETIFELEDEVEQHRAVKLHDNLIISDLENSIKK---LHDQKYDMEKEIKVLH 758

  Fly   143 KKITAASLELTISCVFLREGKATDEDMQSVVSMMSVNNNDVAPLDDLEDIPDL-DGFSEITDNFN 206
            :|:...|.|       .|:.:|   |:|:.|    :..||: ..:..|:|.|| ....|..:...
Zfish   759 RKLREESAE-------WRQFQA---DLQTAV----IIANDI-KTEAQEEIGDLRRRLQEAQEKNE 808

  Fly   207 DFTQQLEHMTT-----------SLNGCID---VATPQSV-----PSLSEDPTPLAESFNPLHFEL 252
            ...::||.:.:           :....::   .|..|.:     .|.|.:|:|..::... .|:.
Zfish   809 KMNKELEELKSRKQDEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPSPTVKTLIK-SFDS 872

  Fly   253 DADGKREAANKLDLPTAASGGSSGAEESLKTPNGLQHVVDQTPIKSPDEVKQPKQTPVESLRSKT 317
            .:.|..:.:     ||||:...:.|.           .:.:||: ||..||.|....|..::..|
Zfish   873 ASQGPVQGS-----PTAAAAAVAAAT-----------AISRTPL-SPSPVKTPPAAAVSPIQRHT 920

  Fly   318 NEDFDKMVTSTPLEPNVNKDDVKPKKKRALFFTEKEDEQDLRVESVKEDTTKTIGDNSTTKEKPK 382
                   ::|.||...::        ||..|       .||.:.:  |...:|   :..|:....
Zfish   921 -------ISSKPLSSMLD--------KRPSF-------NDLNIPA--EHLLRT---SPVTRPGCP 958

  Fly   383 EESQSSKDASSVVVPSAKRPELQPLNLKKSYEPSQTPESAPVPASVINESIGSCFSTSGSLNNSL 447
            .:..::.|.|..:..|.:..|    .||:..   ..|||: .|:|:::....|..|.:.|...|:
Zfish   959 IQRVTNMDTSKAISVSRRSSE----ELKRDL---LAPESS-APSSLMSSPQLSLSSNASSPTASI 1015

  Fly   448 KPVEKIVLKE--------------NTPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIH 498
            .|..:..|:|              .:....||.||::.|:.|.|:.:||.::||.:|:|||||:|
Zfish  1016 TPTTRGRLREERKDPLSALAREYGGSKRNALLRWCQKKTEGYQNIDITNFSSSWNDGLAFCAILH 1080

  Fly   499 HFVPELIDMSKLSAHDVVGNCRIGFDAAESLGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHF 562
            .::|..|...:|::.|...|..:.|.||||:||...::..:|.....||..:||||:..:..:|
Zfish  1081 TYLPAHIPYHELNSLDKRRNFTLAFQAAESVGIKSTLDIGEMVHTERPDWQSVMTYVTSIYKYF 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	14/86 (16%)
		CH	460..562	CDD:237981	37/101 (37%)
		DUF3585	<1027..1122	CDD:288945
specc1lb	XP_021324703.1	SMC_N	429..>840	CDD:330553	27/160 (17%)
specc1lb	XP_021324703.1	CH	1044..1144	CDD:237981	37/99 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910