DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and actn4

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	XP_017951705.1	Gene:	actn4 / 448522	XenbaseID:	XB-GENE-494339	Length:	926	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	162/760 - (21%)
Similarity:	278/760 - (36%)	Gaps:	207/760 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|:...:|..:..|:|:         |.:..:.||.||:..|..|.||.|.|...||
Frog   121 SIGAEEIVDGNTKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISW 185

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:||.|:||...||||:..||...|.|.|....|:.||. |.||::::..|:.....||:.|:
Frog   186 KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAERYLDIPKMLDAEDIVNTARPDEKAI 250

  Fly   552 MTYLHQLRAHFTGKQL------KIEQIGSTADESSYVIGDYK---SDNLS---------QNRINF 598
            |||:......|:|.|.      :|.::.:...|:.:::.||:   ||.|.         :||:
Frog   251 MTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLENRV-- 313

  Fly   599 SHPKSLLLHQNSFDEEINGSNKSEQLSPTSKKDVKNLILYNSKNILDKV-------LSPTKDK-- 654
              |:..:   :...:::.......::....|...|..:..|...:..|:       ..|::.|
Frog   314 --PEKTM---HDMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMV 373

  Fly   655 NSINAS-QHANQSPMLSCQTTPPQDESLDKGSQPGGKE--NSSITTID--PQAASEERQQRLLEQ 714
            :.||.. ||..|                   ::.|.:|  .::|..::  ...|.:.||:.|:.:
Frog   374 SDINNGWQHLEQ-------------------AEKGFEEWLLNAIRRLERLDHLAEKFRQKALIHE 419

  Fly   715 ARRLILETRVKSGGSIESPTRPKLERTISPIHNGAEEFYAEHAKKLELKEPGSPSHRLSD----- 774
            |.....|..:|. ...||.|...::..|.. |...|...|.|..::|  :..:.:..|::
Frog   420 AWTEGKEAMLKQ-KDYESATLADIKALIRK-HEAFESDLAAHQDRVE--QIAAIAQELNELDYYD 480

  Fly   775 -PKVLQSFNAIVERVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMGGNPSNN 838
             |.|    ||..:::..:.:..|.........||..|::.|||||  ..||...||.    |.||
Frog   481 SPSV----NARCQKICDQWDLLGSLTHTRREALEVTEKQLEAIDQ--LYLEYAKRAA----PFNN 535

  Fly   839 RRGGARN--SNPF----LRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRD 897
            ...||..  .:.|    :..|...|...:..:..|.|:|.|            |.......::..
Frog   536 WMEGAMEDLQDMFIVHTIEEIEGLIAAHEQFKSTLPDADRE------------REAILGIQNEAQ 588

  Fly   898 TSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSALS 962
            ..:|                 .||....:.|                    |||.:   :|..::
Frog   589 KIAD-----------------YSHIKLASGN--------------------PYTTV---TPQIIN 613

  Fly   963 SQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQ 1027
            |:......|             ...|..:|:.:.|:                       :::.|.
Frog   614 SKWEKVQQL-------------VPKRDGALKGEHDK-----------------------QQSNEH 642

  Fly  1028 LLSQWFTLVNKKNALLRRQMQ---LNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKER 1089
            |..|:.:|.|.....::.:|:   ...:|....||.:.|.|.|   ..|||.:::..
Frog   643 LRLQFASLANVVGPWIQAKMEEIGRIAIELHGTLEDQMTHLKQ---YEQSVINYKPN-------- 696

  Fly  1090 LLLEELMTIVDKRDQLVQHLHNQEIAIEDDQEIARKLEHVDISAE 1134
                     :||.:|  ||...||..|.|::.....:||:.:..|
Frog   697 ---------IDKLEQ--QHQLIQEALIFDNKHTNYTMEHIRVGWE 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	40/102 (39%)
		DUF3585	<1027..1122	CDD:288945	23/97 (24%)
actn4	XP_017951705.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910