DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and kst

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001097492.2	Gene:	kst / 38418	FlyBaseID:	FBgn0004167	Length:	4337	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	181/866 - (20%)
Similarity:	317/866 - (36%)	Gaps:	230/866 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 TPLEPNVNKDDVKPKKKRALFFTEK-EDEQDLRVESVKEDTTKTIGDNSTTKEKPKEESQSSKDA 391
            ||...|.|..::..:.....|..|: :..|:.|:...|:..||.: ::...|.|.:.|...:..|
  Fly    41 TPTPSNRNSANMTQRDGIIKFENERIKTLQEERLHIQKKTFTKWM-NSFLIKAKMEVEDLFTDLA 104

  Fly   392 SSVVV--------------PSAKRPELQPL-NLKKSYEPSQTPESAPVPASVINESIGSCFSTSG 441
            ..:.:              |::.|..:..: |:.||.        |.:...|..||||:.....|
  Fly   105 DGIKLLKLLEIISSEKLGKPNSGRMRVHKIENVNKSL--------AFLHTKVRLESIGAEDIVDG 161

  Fly   442 S------------LNNSLKPVEKIVLKENTPGQD------LLEWCKEVTKDYPNVKVTNLTTSWR 488
            :            |...::.:|..|.:||...:.      ||.||:..|..||.|.:|:.|.|||
  Fly   162 NPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAKDALLLWCQRKTHGYPGVNITDFTNSWR 226

  Fly   489 NGMAFCAIIHHFVPELIDMSKL--SAHDVVGNCRIGFD-AAESLGIPRVIEPRDMNMLTVPDKLA 550
            :|:.|.|:||...|:|.:.|.:  |.:..:.|....|| ||..||||.:::..|::... ||:.:
  Fly   227 SGLGFNALIHSHRPDLFEYSTIVNSKNSNLDNLNHAFDTAANELGIPSLLDAEDIDSAR-PDEKS 290

  Fly   551 VMTYLHQLRAHFTGKQLKIEQ---------IGSTADESSYVIGDYKS---DNLSQNRINFSHPKS 603
            ::||:...  :.|..::|.||         :|...|      .|.|.   :.|:.|.:::...|:
  Fly   291 ILTYVASY--YHTFARMKNEQKSGKRIANIVGQLMD------ADRKKMQYEGLTTNLLSWIRQKT 347

  Fly   604 LLLHQNSFDEEINGSNKSEQLS----------PTSKKDVKNLILYNSKNILDKVLSPTKDKNSIN 658
            |.|.|......:.|..: |.|:          |..|:..:...||.:.|.|.|.|
  Fly   348 LELEQRDLPNSLEGIQR-ELLAFKEYRTIEKPPKYKERSEIEALYFTINTLLKAL---------- 401

  Fly   659 ASQHANQSPMLSCQTTPPQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARRLILETR 723
                 ||.|.      .|||..|             :..|       |:..::||.|..
  Fly   402 -----NQPPY------NPQDGQL-------------VNDI-------EKAWQILEYAEH------ 429

  Fly   724 VKSGGSIESPTRPKLERTISPIHNGAEEFYAEHAKKLELKEPGSPSHR---LSDPKVLQSFNAIV 785
                 ..|...|.:|.|     ....|:...:..||..|:| |.....   ||||:.|:..:|.:
  Fly   430 -----HREVALRDELLR-----QEKLEQLNYKFEKKSVLRE-GYLKEMIQVLSDPRYLRQVDATL 483

  Fly   786 ERVSPKHE-------KRGDKLSYIDSELEALERE----QEAIDQKASNLEAKLRAVMGGNPSNNR 839
            :    |||       .|.::.:.:.:..|.|:||    :|.:.::...:.||.|.::  ....|:
  Fly   484 K----KHEAISADILARVERFNDLTAMAEELDRENYHGKERVRRREQEVMAKWRQLL--ELLENQ 542

  Fly   840 RGGARNSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSVC 904
            |......:..:.|:|......:.:|                            :..:..:|:.|
  Fly   543 RLNLSQMSNLMNLLREIASTTEAVR----------------------------ELQQQFASEDV- 578

  Fly   905 NSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSALSSQQSSCD 969
              |..| ..:....::||.     .:..:||............:||... :...:||.:|:
  Fly   579 --GPHL-LGVEELLQAHSL-----QELQVNTYGETLKRFNRQALPYKSS-EHKDAALLAQR---- 630

  Fly   970 NLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQLLSQWFT 1034
                       ||......:..|||.    ..||.|.|...:..|.....:.||:       |
  Fly   631 -----------LADLEEAYSELLRRS----AARRARLEEARNFHHFMEDYDNEES-------W-- 671

  Fly  1035 LVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKERLLLEE---LM 1096
            ||:|:. :.:..:....|.....|::|:..|..|:::.:.    :..::....:||:.|:   ..
  Fly   672 LVDKQR-ICKTGITAKDLRAVLSLQQKHKALEDEIKSRKP----KSGQMSTAGKRLIGEQHPRSS 731

  Fly  1097 TIVDKRDQLVQHLHNQEIAIE 1117
            .|..:.|.|.:|....|..:|
  Fly   732 EIQSRIDSLAEHWQALEALVE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	36/110 (33%)
		DUF3585	<1027..1122	CDD:288945	18/94 (19%)
kst	NP_001097492.2	CH	76..178	CDD:237981	20/110 (18%)
		CH	197..303	CDD:237981	37/108 (34%)
		SPEC	450..640	CDD:238103	43/249 (17%)
		SPEC	658..832	CDD:238103	21/109 (19%)
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103
		SPEC	1449..1658	CDD:238103
		SPEC	1555..1764	CDD:238103
		SPEC	1765..1975	CDD:238103
		SPEC	1873..2080	CDD:238103
		SPEC	1979..2185	CDD:238103
		SPEC	2188..2402	CDD:238103
		SPEC	2407..2618	CDD:238103
		SPEC	2514..2725	CDD:238103
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103
		SPEC	3465..3680	CDD:238103
		PH	3799..3902	CDD:278594
		PH_beta_spectrin	3801..3904	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010