DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and Specc1l

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001034544.1	Gene:	Specc1l / 361828	RGDID:	1309570	Length:	1118	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	144/695 - (20%)
Similarity:	240/695 - (34%)	Gaps:	258/695 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 DNHTISVTL---FKDPRTHELEDK------DWTFVIEDVTPMGKKRVLANASINMRKYASIESTQ 131
            |.|.||..:   .|..|..|||.:      :..|..|.:  :|.::.|:| ::.|.:..:.|:
  Rat   472 DEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQL--LGVQQHLSN-TLKMAEQDNKEA-- 531

  Fly   132 QSFTLSLKPVS-------------KKITAASLELTISCVFLREGKAT---------------DED 168
            |....:||..|             |...||:||         |.|||               :::
  Rat   532 QEMIGALKERSHHMERIIESEQKGKAALAATLE---------EYKATVASDQIEMNRLKAQLEKE 587

  Fly   169 MQSVVSMMSVNNNDVAPLDDLEDIPDL---------------------------------DGFSE 200
            .|.|..:.|::|:     .|..||.||                                 |..::
  Rat   588 KQKVAELYSIHNS-----GDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDTIAK 647

  Fly   201 ITDNFNDFTQQLEHMTTSLNGCIDVATPQSVPSLSEDPTPLAESFNPLHFELDADGKREAANKL- 264
            :.|.:..|.::.:.....||..::....:    |.|..|..::....: |||:.:.::..|.||
  Rat   648 VEDEYRAFQEEAKKQIEDLNMTLEKLRSE----LEEKETERSDMKETI-FELEDEVEQHRAVKLH 707

  Fly   265 ---------------------------------------------DLPTA---ASGGSSGAEESL 281
                                                         ||.||   |:...|.|:|.:
  Rat   708 DNLIISDLENTVKKLQDQKHDLERENKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEI 772

  Fly   282 KTPNGLQHVV---DQTPIKSPDEVKQPKQ-----------TPVE------------SLRSKTNED 320
            .......|..   ::...|..:|:|..||           ..||            |.||.|:.:
  Rat   773 GDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSE 837

  Fly   321 -----------FDK----------MVTSTPLEPNVNKDD----VKPKKKRALF--------FTEK 352
                       ||.          .:..|||.|:..|..    |.|.::.::.        .|..
  Rat   838 PTPTVKTLIKSFDSASQVPNAAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPVSTSKPLTAL 902

  Fly   353 EDEQD-----------LRVESVKE----------DTTKTIGDNSTTKEKPKEESQSSKDAS--SV 394
            .|::.           ||..|...          ::.|||..:..:.|:.|.:..:|:.||  |:
  Rat   903 SDKRSNYGEIPGQEHLLRTSSTSRPASLPRVPAMESAKTISVSRRSSEEMKRDISASEGASPASL 967

  Fly   395 VVPSAKRPELQPLNLKKSYEPSQTP-------ESAPVPASVINESIGSCFSTSGSLNNSLKPVEK 452
            :......|:   |:|..|...|.||       |....|.|.:....|      ||..|:
  Rat   968 MAMGTTSPQ---LSLSSSPTASVTPSTRSRIREERKDPLSALAREYG------GSKRNA------ 1017

  Fly   453 IVLKENTPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVG 517
                       ||:||::.|:.|.|:.:||.::||.:|:||||::|.::|..|...:|::.:...
  Rat  1018 -----------LLKWCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQEKKR 1071

  Fly   518 NCRIGFDAAESLGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHF 562
            |..:.|.||||:||...::..:|.....||...||.|:..:..:|
  Rat  1072 NFTLAFQAAESVGIKSTLDINEMARTERPDWQNVMLYVTAIYKYF 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	27/110 (25%)
		CH	460..562	CDD:237981	34/101 (34%)
		DUF3585	<1027..1122	CDD:288945
Specc1l	NP_001034544.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..175
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..324
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..391
		DUF342	<626..703	CDD:302792	11/81 (14%)
		Abhydrolase	852..>969	CDD:304388	21/116 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..999		20/85 (24%)
		CH	1016..1116	CDD:237981	35/116 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000