DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and SMTNL2

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001108446.1	Gene:	SMTNL2 / 342527	HGNCID:	24764	Length:	461	Species:	Homo sapiens

Alignment Length:	429	Identity:	99/429 - (23%)
Similarity:	158/429 - (36%)	Gaps:	133/429 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 GKATDEDMQSVVSMMSVNNNDVAPLDDLEDIPDLDGFSEITDNFN----------DFTQQLEHM- 215
            |::.|.|..|...|...:|:.:............||..||..||:          ..:.:|.|.
Human   132 GQSLDHDEASESEMRKTSNSCIMENGHQPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQP 196

  Fly   216 TTSLNGCID---------VATPQSV-------PSLSEDPTPLAESFNPLHFELDADGKREAANKL 264
            .|::....|         ..:|.|.       ||.||..||...|          ..::.::...
Human   197 VTAITRVSDRFSGETSAAALSPMSAATLGGLNPSPSEVITPWTPS----------PSEKNSSFTW 251

  Fly   265 DLPTAASGGSSGAEESLKTPNGLQHVVDQTPIKSPDEVKQPKQTPVESLRSKTNEDFDKMVTSTP 329
            .:|::..|..:.::.|...|     :|  ||.:||...:.|..|.|.....:..|    :|.|..
Human   252 SVPSSGYGAVTASKHSNSPP-----LV--TPPQSPVSPQPPAITQVHRQGERRRE----LVRSQT 305

  Fly   330 LEPNVNKDDVKPKKKRALFFTEKEDEQDLRVESVKEDTTKTIGDNSTTKEKPKEESQSSKDASSV 394
            | |..:    :.:.::|||  ||.:::                   |...|.|.|:::
Human   306 L-PRTS----EAQARKALF--EKWEQE-------------------TAAGKGKGEARA------- 337

  Fly   395 VVPSAKRPELQPLNLKKSYEPSQTPESAPVPASVINESIGSCFSTSGSLNNSLKPVEKIVLKENT 459
                         .||:|                  :|.|...::|              :|
Human   338 -------------RLKRS------------------QSFGVASASS--------------IK--- 354

  Fly   460 PGQDLLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFD 524
              |.|||||:..|..|.:|.:.|.::||.:||||||::|.|.|:..|.:.||......|..:.|.
Human   355 --QILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFT 417

  Fly   525 AAESL-GIPRVIEPRDMNML-TVPDKLAVMTYLHQLRAH 561
            .||:| ...|:||..||.:: ..||.:.|.||:..|..|
Human   418 MAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNH 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	1/2 (50%)
		CH	460..562	CDD:237981	41/104 (39%)
		DUF3585	<1027..1122	CDD:288945
SMTNL2	NP_001108446.1	SlyX	<56..92	CDD:294687
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..193		12/60 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..248		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..307		14/58 (24%)
		CH	354..458	CDD:237981	42/108 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910