DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and actn4

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	XP_021337009.1	Gene:	actn4 / 322221	ZFINID:	ZDB-GENE-030131-940	Length:	923	Species:	Danio rerio

Alignment Length:	755	Identity:	152/755 - (20%)
Similarity:	279/755 - (36%)	Gaps:	195/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|:...:|..:..|:|:         |.:..:.||.||:..|..|.||.|.|...||
Zfish   118 SIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISW 182

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:||.|:||...|||||..||...|.|.|....|:.||. |.||::::..|:.....||:.|:
Zfish   183 KDGLAFNALIHRHRPELIDYDKLRKDDPVTNLNNAFEVAERYLDIPKMLDAEDIVGTLRPDEKAI 247

  Fly   552 MTYLHQLRAHFTGKQL------KIEQIGSTADESSYVIGDYK---SDNLS---------QNRINF 598
            |||:......|:|.|.      :|.::.:...|:.:::.||:   ||.|.         :||
Zfish   248 MTYVSCFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLENR--- 309

  Fly   599 SHPKSLLLHQNSFDE--EINGSNKSEQLSPTSKKDVKNLILYNSKNILDK-VLSPTKDK--NSIN 658
            :..|::...|...::  :....:|..::....:.::....|.....:.:: ...|::.:  :.||
Zfish   310 APEKTMAEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDIN 374

  Fly   659 ASQHANQSPMLSCQTTPPQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARRLILETR 723
            .:.|              :.|..:||                      .::.||.:.|||
Zfish   375 GAWH--------------KLEGAEKG----------------------YEEWLLNEIRRL----- 398

  Fly   724 VKSGGSIESPTRPKLE------RTISPIHNGAEEFYAEHAKKLELKEPGSPSHRLSDPKVLQSFN 782
                        .:|:      |..:.||.|..:     .|:..|.:....:..||:.|.|...:
Zfish   399 ------------ERLDHLAEKFRQKAAIHEGWTD-----GKEAMLTQKDYETASLSEIKALLKKH 446

  Fly   783 AIVERVSPKHEKRGDKLSYIDSELEALE-REQEAIDQKASNLEAKLRAVMGGNPSNNRRGGARNS 846
            ...|.....|:.|.::::.|..||..|: .:..:::.:...:..:..|:  |:.:.|||.....:
Zfish   447 EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICEQWDAL--GSLTQNRRESLERT 509

  Fly   847 NPFLRLIRNSIGGGDVIRIKLLDSDDE---SLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGD 908
            .                  |.|:|.||   ......|.......||..:..|.     .:.::.|
Zfish   510 E------------------KQLESIDELYLEYAKRAAPFNNWMEGAMEDLQDM-----FIVHNID 551

  Fly   909 ELHTRLRPRPRSHSCF--VNKNHQSTINTPAHLRPHHVHHVV------PYTHMLDSSPSALSSQQ 965
            |:...:....:..|..  .||..::.....|.::....::.:      |||.:   :|.::..:.
Zfish   552 EIQGLITAHEQFKSTLPEANKEREAIQAIQAEVQKIANYNGIKLAGNNPYTTI---TPQSIDKKW 613

  Fly   966 SSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQLLS 1030
            .....|  ....|:.|       ...|.|||.....|||                 ...:..::.
Zfish   614 EKVQQL--VPQRDQAL-------QEELTRQQSNDHLRRQ-----------------FANQANMIG 652

  Fly  1031 QWFTLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKERLLLEEL 1095
            .|  :.||...:.|..:::|     ..||.:.|.|:|   ..||:.:::....|.|.:..|:
Zfish   653 PW--IQNKMEEIGRISIEMN-----GTLEDQLTHLSQ---YEQSIIEYKPNIDQLEGDHQLI--- 704

  Fly  1096 MTIVDKRDQLVQHLHNQEIAIEDDQEIARKLEHVDISAEK 1135
                            ||..|.|::..|..:||:.:..|:
Zfish   705 ----------------QEALIFDNKYTAYTMEHLRVGWEQ 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	41/102 (40%)
		DUF3585	<1027..1122	CDD:288945	19/94 (20%)
actn4	XP_021337009.1	SAC6	38..>402	CDD:227401	77/339 (23%)
		SPEC	404..631	CDD:238103	44/268 (16%)
		Spectrin	639..742	CDD:306853	26/136 (19%)
		EFh_PEF	749..>880	CDD:330173
		EFhand_Ca_insen	853..919	CDD:312305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910