DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and pigs

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001245550.1	Gene:	pigs / 31596	FlyBaseID:	FBgn0029881	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	147/719 - (20%)
Similarity:	239/719 - (33%)	Gaps:	190/719 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 LNNSLKPVEKIVLKENTPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNG----MAFCAIIHHFVPE 503
            :.|.||.::::|       :||:|.| .....:|.|:|:.  ..:|.|    :.|..|:...|..
  Fly   250 ITNDLKSLDEMV-------RDLVEKC-TCPSQFPMVRVSE--GKYRIGDTKVLIFVRILRSHVMV 304

  Fly   504 LID------MSKLSAHDVVGNCRIGFDAAESLG---IPRV---------IEPRDMNMLTVPDKLA 550
            .:.      ...|..||   .||.......|:.   |||.         ||
  Fly   305 RVGGGWDTLSHYLDKHD---PCRCRAQHRSSVAARLIPRQSPNHNPSNGIE-------------- 352

  Fly   551 VMTYLHQLRAHF---------------------TGKQLKIEQIGSTADESSYVIGDYKSDNLSQN 594
                ||:.:..|                     ||.......:| .|...:...|...|.|..:.
  Fly   353 ----LHKAQVIFERSPPAARRVFNSPNCNGGPGTGSSCGTGVVG-VAVPPTLQNGHSLSPNSGKY 412

  Fly   595 RINFSHPKSLLLHQNSFDEEINGSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPT-------- 651
            |.....|:...|:|.:....|..:..|.|   |...|..:..|..|.::..:.:||:
  Fly   413 RSRSPTPQRKFLNQQANGGGIASATGSSQ---TVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMR 474

  Fly   652 KDKNSINASQHANQS-PMLSCQTTPPQDESLDKGSQPGGKENSSI-TTIDPQAASEERQQRLLEQ 714
            |.::|:::.....:| |..||........| ..||..||..:.|. :.:..:.....:.:.:.:.
  Fly   475 KKQSSLDSYSSGPKSLPGYSCSMEEANGGS-GVGSAAGGVSSGSAGSGVAGEQGGANKFENISDN 538

  Fly   715 ARRL---------ILET------RVKSGGSIE-SPTRPKLERT-----ISPIHNGAEEFYAEHAK 758
            ...:         ::::      .:.|..||| :.:..:|::|     |||....||:...:..:
  Fly   539 GSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQISPSDEPAEKATTDILE 603

  Fly   759 KLEL----KEPGSPSHRLSD-PKVLQSFNAIVERVSPKHEKRGDKLSYIDSELEALEREQEAIDQ 818
            :.:|    :|.....:.:.| |:.|.:..:...::|.|.|:.|  :...|.|:.....:.|  ||
  Fly   604 EEDLNGQDREEDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSG--VFITDDEITVDIAKTE--DQ 664

  Fly   819 KASNLEAKLRAVMGGNPSNNRRGGARNSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSG 883
            ..:|..        |||:.|.....|  :|..:..|.||              |.|..||..||
  Fly   665 SVANTM--------GNPTPNLSKIPR--SPLAQRRRRSI--------------DNSTCGGAGGS- 704

  Fly   884 GGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVV 948
                       .:|.||    .||.......|.:|...|.   :...||..|...:.|.......
  Fly   705 -----------LQDLSS----RSGLPAPAFSRKQPVYRSV---RTRNSTGATTTPVAPPRSRQAT 751

  Fly   949 PYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQ-------RR 1006
            ....:.|.:.:.......:....|.|:.|..|......|.|.|..|  :...|..|       ||
  Fly   752 QLPMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFER--NGKGRSSQILYDSNGRR 814

  Fly  1007 ER------RSHLCHTP--NHCETEETEEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLERKYT 1063
            .|      .|.|..:|  ||. :....:|||.   ...:.||       ...|||:.|.|..:|.
  Fly   815 VRSGAPGCTSSLTTSPVKNHA-SSPLAQQLLE---AASSAKN-------DAQILEKMKSLLSRYA 868

  Fly  1064 MLNQ 1067
            ..||
  Fly   869 AGNQ 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	25/123 (20%)
		DUF3585	<1027..1122	CDD:288945	13/41 (32%)
pigs	NP_001245550.1	CH	22..159	CDD:237981
pigs	NP_001245550.1	GAS2	258..325	CDD:280367	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930