DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and Smtnl1

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001178668.1	Gene:	Smtnl1 / 311167	RGDID:	1311701	Length:	470	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	103/468 - (22%)
Similarity:	173/468 - (36%)	Gaps:	147/468 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 SEDPTPLAESFNPLHFELDADGKREAANKLDLPTA--ASGGSSGAEESLKTPNGLQH-------- 289
            |||.|    :.:|....|...|.:..|.::...||  .:.|:.|..:..:.|:|.:|
  Rat     9 SEDGT----TVSPTAGNLATPGSQGTAEEVAEGTAEEVAEGTVGTNDKEEPPDGAEHLCKAASEG 69

  Fly   290 -----------VVDQTPIKSPDEVKQPKQTPVESLRSKTNEDFDKMVTSTPLEPNVNKDDVKP-- 341
                       ::::....|..|.:..::...:....|..:: |..|:|.  |....|::.||
  Rat    70 GISGGCQVEASILEELKTDSQGEARGKEEAKADLAEEKGGKE-DTTVSSQ--EDTGKKEETKPEP 131

  Fly   342 ----KKKRALFFTEKE--DEQDLRVES-----------------------VKE------------ 365
                :|:.|:...||:  ||::..:||                       |||
  Rat   132 SEVTEKEEAVLPLEKQKVDEKETNLESKEKSDVNDKAEPESKEDAGAEVTVKEAETESQKKADVK 196

  Fly   366 -----------------DTTKTIGDNSTTKEKPKEESQSSKDASSVVVPSAKR--PE-------- 403
                             ||.:.:...|.|:|:.::..::..:..:.|:||:..  ||
  Rat   197 DQAEPQLQEVDGKEARSDTKELVEPGSPTEEQEEQGKENESEERAAVIPSSPEDWPESPTDEGTS 261

  Fly   404 LQPLNL-------------KKSYEPSQTPES--APVPA--------------------------S 427
            |.|..|             .....||:.|||  .|:|:                          .
  Rat   262 LSPDGLGPESTASGETSASASESSPSEVPESPTEPLPSEKKKERAPERRVSAPTRPRGPRAQNRK 326

  Fly   428 VINESIGSCFSTSGSLNNSLKPVEKIV--LKENTPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNG 490
            .|.:..|...|...:|..:.|.....:  :|..     |||||:.:|::|.:|.:.|.::||.:|
  Rat   327 AIMDKFGGAASGPTALFRNTKAAGAAIGGVKNM-----LLEWCRAMTRNYEHVDIQNFSSSWSSG 386

  Fly   491 MAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAESLG-IPRVIEPRDMNMLTVPDKLAVMTY 554
            |||||:||.|.|:..|.::|.......|..:.|..||.|. ..:::|..||..|.|||...|.||
  Rat   387 MAFCALIHKFFPDAFDYAELDPTKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTY 451

  Fly   555 LHQLRAHFTGKQL 567
            :.:|......|.|
  Rat   452 IQELYRSLVQKGL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	39/102 (38%)
		DUF3585	<1027..1122	CDD:288945
Smtnl1	NP_001178668.1	CH	357..457	CDD:237981	40/104 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840