DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and Actn2

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001163796.1	Gene:	Actn2 / 291245	RGDID:	1308097	Length:	894	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	154/781 - (19%)
Similarity:	273/781 - (34%)	Gaps:	249/781 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|::..:|..:..|:|:         |.:..:.||.||:..|..|.||.:.|..|||
  Rat   116 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:..||:||...|:|||.|||:..|.:||..:..:.||. |.||::::..|:.....||:.|:
  Rat   181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAI 245

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIG-DYKSDNLSQNRINFSHPKSLLLH-------- 607
            |||:......|.|    .||..:.|:....|:. :.:::.|.:   .:....|.||.
  Rat   246 MTYVSCFYHAFAG----AEQAETAANRICKVLAVNQENERLME---EYERLASELLEWIRRTIPW 303

  Fly   608 -QNSFDEEINGSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSC 671
             :|...|      |:.|......:|.::   |..|:...||....:.:.:.|..|     ..|..
  Rat   304 LENRTPE------KTMQAMQKKLEDFRD---YRRKHKPPKVQEKCQLEINFNTLQ-----TKLRI 354

  Fly   672 QTTP---PQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARR-----LILETRVKSGG 728
            ...|   |.:          ||..|.|      |.:.:|    ||||.:     |:.|.|
  Rat   355 SNRPAFMPSE----------GKMVSDI------AGAWQR----LEQAEKGYEEWLLNEIR----- 394

  Fly   729 SIESPTRPKLERTISPIHNGAEEFYAE--------HAKKLELKEPGSPSHRLSDPKVLQSFNAIV 785
                    :|||    :.:.||:|..:        :.|:..|.:....|..|::.:.|...:...
  Rat   395 --------RLER----LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAF 447

  Fly   786 ERVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMGGNPSNNRRGGARNSNPFL 850
            |.....|:.|.::::.|..||..|:..
  Rat   448 ESDLAAHQDRVEQIAAIAQELNELDYH-------------------------------------- 474

  Fly   851 RLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGDELHTRLR 915
                      |.:.:                            :||   ...:|:..|.|.|..:
  Rat   475 ----------DAVNV----------------------------NDR---CQKICDQWDRLGTLTQ 498

  Fly   916 PRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPY----------------THMLDSSPSALSSQ 964
            .|..:     .:..:..:.|...|.........|:                .|.::...|.:::.
  Rat   499 KRREA-----LERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAH 558

  Fly   965 QSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQLL 1029
            :.....||           .|:|...|:...|:...:..|....|   ..:.|...| .|.::|.
  Rat   559 EQFKATLP-----------EADGERQSILAIQNEVEKVIQSYSIR---ISSSNPYST-VTMDELR 608

  Fly  1030 SQWFTLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELR---AAQ--SVEDWRKTEVQREKER 1089
            ::|..:   |..:..|...|     :::|.|::.  |:.||   |||  ::..|    :|.:.|.
  Rat   609 NKWDKV---KQLVPVRDQSL-----QEELARQHA--NERLRRQFAAQANAIGPW----IQNKMEE 659

  Fly  1090 LLLEELM---TIVDKRDQLVQHLHN------------------QEIAIEDDQEIARKLEHVDISA 1133
            :....:.   .:.|:.:||.|:.||                  ||..:.|::.....:||:.:..
  Rat   660 IARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGW 724

  Fly  1134 E 1134
            |
  Rat   725 E 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	39/102 (38%)
		DUF3585	<1027..1122	CDD:288945	25/120 (21%)
Actn2	NP_001163796.1	CH_ACTN_rpt1	35..139	CDD:409063	6/22 (27%)
		CH_ACTN_rpt2	143..257	CDD:409065	40/113 (35%)
		Spectrin	281..391	CDD:395348	29/146 (20%)
		SPEC	402..629	CDD:238103	44/333 (13%)
		Spectrin	637..739	CDD:395348	20/93 (22%)
		PTZ00184	747..>851	CDD:185504
		EFhand_Ca_insen	824..890	CDD:400872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900