DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and Smtnl2

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_808444.1	Gene:	Smtnl2 / 276829	MGIID:	2442764	Length:	456	Species:	Mus musculus

Alignment Length:	419	Identity:	99/419 - (23%)
Similarity:	157/419 - (37%)	Gaps:	108/419 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 QLEHMTTSLNGCIDVATPQSVPSLSEDPTPLA-----------ESFNPLHFELDADGK-----RE 259
            |||.:|..:. .:.:||..|....:..|.|.|           ..|:. |......|:     .:
Mouse    73 QLERLTRQVE-ALGLATGVSPAPGTPSPPPAATVTDRAPRLGTARFSS-HATFSLSGRSPSVEHD 135

  Fly   260 AANKLDLPTAASGGSSGAEESLKTPNGLQHVVDQTPIKSPDEV------KQPKQTPVE-SLR--- 314
            .|:.|::..|::        |....||  |.:|..|.....||      :.|:..||. |||
Mouse   136 EASDLEVRRASN--------SCILENG--HQLDAGPANGSSEVQTSSAQEPPRPRPVSLSLRMPH 190

  Fly   315 ------SKTNEDFDKMVTSTPLEPNVNKDDVKPKKKRALF--FTEKEDEQDLRVESVKEDTTKTI 371
                  ::.:|.|....:::.|.|.          ..|:.  ||....      |::...|
Mouse   191 QPVTAVTRVSEKFSGETSASALSPT----------SAAIVGGFTPSPS------EAISPWT---- 235

  Fly   372 GDNSTTKEKPKEESQSSKDASSVVVPSAKRPELQPLNLKKSYEPSQTPESAPVPAS--------- 427
               .:..||....::|...:....|.:.||.:..||     ..|.|:|.|:..||.
Mouse   236 ---PSPTEKSSSFTRSLSGSGYGAVTAGKRKDSPPL-----VTPPQSPPSSQPPAMTQAPRQGER 292

  Fly   428 ----VINESI------------------GSCFSTSGSLNNSLKPVEKI-VLKENTPGQDLLEWCK 469
                |.::::                  .:.....|.....||..:.. |...::..|.|||||:
Mouse   293 RRELVRSQTLPRTSGAQARKALFEKWEQDTASKGKGETRAKLKRSQSFGVASASSIKQILLEWCR 357

  Fly   470 EVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAESL-GIPR 533
            ..|..|.:|.:.|.::||.:||||||::|.|.|:..|.:.||......|..:.|..||:| ...|
Mouse   358 SKTVGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNALSPTQRQKNFELAFTMAENLANCER 422

  Fly   534 VIEPRDMNML-TVPDKLAVMTYLHQLRAH 561
            :||..||.:: ..||.:.|.||:..|..|
Mouse   423 LIEVEDMMVMGRKPDPMCVFTYVQSLYNH 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	41/104 (39%)
		DUF3585	<1027..1122	CDD:288945
Smtnl2	NP_808444.1	SlyX	<56..89	CDD:294687	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..140		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..190		12/37 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..310		19/107 (18%)
		CH	349..453	CDD:237981	41/103 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910