DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ehbp1 and Micall2

DIOPT Version :9

Sequence 1:NP_995865.2 Gene:Ehbp1 / 36912 FlyBaseID:FBgn0034180 Length:1141 Species:Drosophila melanogaster
Sequence 2:NP_777275.2 Gene:Micall2 / 231830 MGIID:2444818 Length:1009 Species:Mus musculus


Alignment Length:1011 Identity:189/1011 - (18%)
Similarity:319/1011 - (31%) Gaps:355/1011 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   464 LLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAA-E 527
            |.|||::..:.|.:|.:||:|||:|:|:|||||:|...|:||:.|.|...::..|.::.|..| |
Mouse     7 LQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFSALRKENIYENNKLAFQVAEE 71

  Fly   528 SLGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHFTGKQ-------------------------- 566
            .||||.:::..||..|.|||:|:::||:.|...:|.|:.                          
Mouse    72 QLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKRPSSDSTEELSGKKGLS 136

  Fly   567 ----------------------------------------------------------------- 566
                                                                             
Mouse   137 QPAKLPSPAQTQRSPLSPARTNPVVQRNEGGSQRPSPKAAPGTAGSSVSSICGVCGKHVHLVQRH 201

  Fly   567 -----------LKIEQIGSTADESSY-VIGD-----------------YKSDNLSQNRINFSHPK 602
                       .:.:|..||....:| ..|:                 .||.||:..:     |.
Mouse   202 LADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCTHHSSEVTSVSPKSSNLASRK-----PG 261

  Fly   603 SLLLHQNSFD-----EEINGSNK----------------------SEQLSPTSKKDVK------- 633
            .:......|.     :|.||...                      ..:|.|.|...|.       
Mouse   262 GVTADTRPFGVSWTVQEANGEGTPLRVRTAAWEHAGGNTTAKGFVQTELKPPSTSQVHVGSSAGP 326

  Fly   634 --NLILYNSKNILDKVLSPTKDKNSINASQHANQSP---------MLSCQTT---PPQDESLDKG 684
              ..|...:.::..|.|:...:.:.|..|..|..||         ..|.:.|   ..|.::..||
Mouse   327 KLPTITVTTTSVTSKALTHVTNSSPIGWSSPAQSSPANFNSRPVVSPSARNTHLPGSQGQTASKG 391

  Fly   685 --SQPGGKENSSITTIDPQAASEERQQRLLEQARRLILETRVKSGGSIESP-------------- 733
              :|......||.|.:.|...|...:   .:|||....:|...:.....:|              
Mouse   392 VKTQLNLNSESSNTAVTPAWTSSASK---TQQAREKFFQTPPSAPAPASAPAPAPTSKVPTVVTV 453

  Fly   734 ---------TRP--KLERTISPIHNGAEEFYAEHAKKLEL-------KEP---GSPSHRLSD--- 774
                     |.|  |:...::...:......:....|:..       |.|   .|.:.|::.   
Mouse   454 PTSKVPNVVTAPTSKVPTVVTVPTSKVPTVVSAPTSKVPTVVSAPTSKVPTVVNSTNSRVTTVVN 518

  Fly   775 ------PKVLQSFNAIVERVSPKHEKR--------GDKLS-YIDSELEALEREQ----------- 813
                  |.|:.:.|..|..|...|..|        ..|:| .:|:..:...|||           
Mouse   519 APTSKVPTVVSATNGRVPTVVTAHTGRVPAVMNTSASKVSPVVDAPAQESSREQALSVLRKALPA 583

  Fly   814 -------------------------------------EAIDQKASNLEAKLR---AVMGGNPSNN 838
                                                 .|:..:..|...||.   .|..||.:..
Mouse   584 LTGSGTQAPNRSFPATSSVLVTLPKNEVPQKVPSDKLSALTTQTPNFTIKLEPSAPVNVGNTAVF 648

  Fly   839 RRGGARNSNPFLRLIRNSIGG---GDVIRIK-----LLDSDDESLFGGGA-------GSGGGRS- 887
            .:.|.::.:...|:.:.|:|.   .:|..:|     ..:..:|...|..|       .:..||| 
Mouse   649 LQAGKKSPSISPRVGKTSVGSRPQAEVAGVKGPGPISQEGQEEGPEGWRARLKPVDKKTPAGRSL 713

  Fly   888 ----GACSEDDDRDTSSDSVCNSGDELHTRL-------RPRPRSHSCFVNKNHQSTINTPAHLRP 941
                ...:|....|||..:..:|...:|..|       :|.|....           .:||.|.|
Mouse   714 EQKEPVLAEPRIGDTSRKASSSSDSSVHITLTSIQHKRKPCPAGSG-----------PSPAALSP 767

  Fly   942 HHVHH---VVPYTHMLDSSPSALSSQ-QSSCDNLPACSDD--------------DEVLAVAANGR 988
            ...|.   .||.:  ||.|...|..: :...|...:|.::              |..||......
Mouse   768 SPSHRKKLAVPPS--LDVSADWLQPEPKKQEDGTRSCKEEKSPTRWSRERSAVLDSGLAPPGEAV 830

  Fly   989 AASLRRQQD---RHRRRRQRRERRSHLCHTP----------NHCETEETEEQLLSQWFTLVNKKN 1040
            .:.:|...|   :...:||.::..|.|....          ...|.:.:|:.|:..||.|:::|.
Mouse   831 TSPVRLHPDYIPQEELQRQLQDIESQLDALELRGVELEKRLRAAEGDASEDSLMVDWFRLIHEKQ 895

  Fly  1041 ALLRRQMQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKERLLLEELMTIVDKRDQL 1105
            .|||.:.:|....:::.||.:...|..|||......:..|:...|::|:.||.:.:..|:.|..:
Mouse   896 LLLRLESELMYKSKDQRLEEQQLDLQGELRRLMDKPEGLKSPQDRQREQELLSQYVNTVNDRSDI 960

  Fly  1106 VQHLHNQEI-AIEDDQEIARKLEHVDISAEKDKCVL 1140
            |..|....: ..|:||.:...::::.:..:|.|..|
Mouse   961 VDFLDEDRLREQEEDQMLENMIQNLGLQRKKSKSFL 996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ehbp1NP_995865.2 NT-C2 12..165 CDD:287345
CH 460..562 CDD:237981 42/98 (43%)
DUF3585 <1027..1122 CDD:288945 27/95 (28%)
Micall2NP_777275.2 Forms an intramolecular interaction with the C-terminal coiled coil domain keeping the protein in a closed conformation 1..260 53/257 (21%)
CH 5..102 CDD:278723 41/94 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..180 0/65 (0%)
LIM_Mical_like_1 188..241 CDD:188828 5/52 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..268 5/25 (20%)
Mediates targeting to the cell plasma membrane 261..805 94/559 (17%)
Necessary and sufficient for interaction with actinins 261..393 21/131 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..447 21/101 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..834 36/191 (19%)
Forms an intramolecular interaction with the N-terminal Calponin-homology and LIM zinc-binding domains-containing region keeping the protein in a closed conformation 806..913 20/106 (19%)
DUF3585 842..978 CDD:288945 33/135 (24%)
Mediates interaction with RAB13 and is required for transition from the closed to the open conformation 913..1009 21/84 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839259
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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