DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and SMTNL1

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001099035.2	Gene:	SMTNL1 / 219537	HGNCID:	32394	Length:	494	Species:	Homo sapiens

Alignment Length:	473	Identity:	114/473 - (24%)
Similarity:	178/473 - (37%)	Gaps:	101/473 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 REGKATDEDMQSVVSMMSVNNNDVAPL---------DDLE-DIPDLDGFSEITDNFNDFTQQLEH 214
            ::.||..||..|.......|..|...:         :|.| ::...||..|.|      |...:.
Human    52 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEET------TVGSQE 110

  Fly   215 MTTSLNGCIDVATPQSVPSLSEDPTPLAESFNPLHFELDA---DGKREAANKLDLPTAASGGSSG 276
            ||....      ..:|.|..:|:......|......|.:|   .|::..||..|.|...   ::.
Human   111 MTGRKE------ETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPK---ATV 166

  Fly   277 AEESLKTPNGLQHVVDQTPIKSPDEVKQPKQTPVESLRSKTNED---------FDKMVTSTPLEP 332
            .||..||             .|.:|..|.|:...|.....|:|:         .:....:.|.||
Human   167 EEEDAKT-------------ASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEP 218

  Fly   333 NVNKDDVKPKKKRALFFTEKEDEQDLRVESVKEDTTKTI-----GDNSTTKEKPKEESQS----- 387
            :..::.....|:.|....|.||.::....|..|:..:.:     |........|:|..:|
Human   219 DGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEG 283

  Fly   388 ---SKD-------ASSVVVPSAKRPELQPLNLKKSYEPSQTP------ESAP-----VPA----- 426
               |.|       ||....|||.  |..|.::.:|  |.::|      |.||     .||
Human   284 HNLSTDGLGPDCVASGQTSPSAS--ESSPSDVPQS--PPESPSSGEKKEKAPERRVSAPARPRGP 344

  Fly   427 ------SVINESIGSCFSTSGSLNNSLKPVEKIVLKENTPGQDLLEWCKEVTKDYPNVKVTNLTT 485
                  :::::..|:....:....|:......|...:|.    |||||:.:||.|.:|.:.|.::
Human   345 RAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNM----LLEWCRAMTKKYEHVDIQNFSS 405

  Fly   486 SWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAESLG-IPRVIEPRDMNMLTVPDKL 549
            ||.:||||||:||.|.|:..|.::|.......|..:.|..||.|. ..::::..||..|.|||..
Human   406 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSK 470

  Fly   550 AVMTYLHQLRAHFTGKQL 567
            .|.||:.:|......|.|
Human   471 CVYTYIQELYRSLVQKGL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	1/4 (25%)
		CH	460..562	CDD:237981	39/102 (38%)
		DUF3585	<1027..1122	CDD:288945
SMTNL1	NP_001099035.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..348		69/327 (21%)
		2A1904	<19..278	CDD:273344	51/253 (20%)
		CH	380..481	CDD:366016	40/104 (38%)
		Calmodulin-binding. /evidence=ECO:0000250	476..494		3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840