DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ehbp1 and Actn3

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_038484.1	Gene:	Actn3 / 11474	MGIID:	99678	Length:	900	Species:	Mus musculus

Alignment Length:	761	Identity:	170/761 - (22%)
Similarity:	279/761 - (36%)	Gaps:	207/761 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|:|..:|..:..|:|:         |.:..:.||.||:..|..|.||.|.|..|||
Mouse   122 SIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSW 186

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:|.||:||...|:|||.:||...|.:||....|:.||. |.||::::..|:.....||:.|:
Mouse   187 KDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAI 251

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQNRINFSHPKSLLLHQNSFDEEIN 616
            |||:......|.|    .||..:.|                 |||    .|.|.::|
Mouse   252 MTYVSCFYHAFAG----AEQAETAA-----------------NRI----CKVLAVNQ-------- 283

  Fly   617 GSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSCQTTPPQDESL 681
               ::|:|....:|....|:.:..:.:                       |.|..:...|
Mouse   284 ---ENEKLMEEYEKLASELLEWIRRTV-----------------------PWLENRVGEP----- 317

  Fly   682 DKGSQPGGKENSSITTIDPQAASEERQQRLLE---QARRLILETRVKSGGSIE---SPTRPKLER 740
                                  |....||.||   ..|||....||:....:|   :..:.||..
Mouse   318 ----------------------SMSAMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRL 360

  Fly   741 TISPIHNGAE----EFYAEHAKKLELKEPGSPSHRLSDPKVLQSFNAIVERVSPK---HE--KRG 796
            :..|....:|    ...|...:.||..|.|.....||:.:.||....:.|:...|   ||  .||
Mouse   361 SHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRG 425

  Fly   797 DKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMGGNPSNNRRGGARNSNPFLRLIRNSIGGGD 861
            .:        |.|.:.    |.::::|: ::||::       ||..|..|:......|
Mouse   426 KE--------EMLNQH----DYESASLQ-EVRALL-------RRHEAFESDLAAHQDR------- 463

  Fly   862 VIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVN 926
            |..|..|..:...|....|.|...|..|             :|:..|.|.|..:.|..:     .
Mouse   464 VEHIAALAQELNELDYHEAASVNSRCQA-------------ICDQWDNLGTLTQKRRDA-----L 510

  Fly   927 KNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAAS 991
            :..:..:.|...|:........|:.:.||.                |..|..:|..|.:.....|
Mouse   511 ERMEKLLETIDQLQLEFARRAAPFNNWLDG----------------AIEDLQDVWLVHSVEETQS 559

  Fly   992 L--RRQQDRHRRRRQRRERRSHL---CHTPNHCETEETEEQLLSQWFTL----VNKKNALLRRQM 1047
            |  ..:|.:.......|||.:.|   ......|:|.....:..:.:.||    :|.|...:|:.:
Mouse   560 LLTAHEQFKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLV 624

  Fly  1048 QLNILEQEKDLERKYTMLNQELR---AAQ--SVEDWRKTEVQREKERLL------LEELMTIVDK 1101
            .......:::|.|:  .:|:.||   |||  ::..|.:.:|: |..||.      |||.|..:.:
Mouse   625 PSRDQTLQEELARQ--QVNERLRRQFAAQANAIGPWIQGKVE-EVGRLAAGLAGSLEEQMAGLRQ 686

  Fly  1102 RDQ-LVQHLHN-----------QEIAIEDDQEIARKLEHVDISAEK 1135
            ::| ::.:..|           ||..:.|::.....:||:.:..|:
Mouse   687 QEQNIINYKSNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQ 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	41/102 (40%)
		DUF3585	<1027..1122	CDD:288945	27/121 (22%)
Actn3	NP_038484.1	Actin-binding	1..260		50/137 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		SAC6	42..>305	CDD:227401	65/218 (30%)
		Spectrin 1	287..397		26/159 (16%)
		Spectrin	287..396	CDD:334073	26/158 (16%)
		Spectrin 2	407..512		30/149 (20%)
		SPEC	408..635	CDD:238103	53/287 (18%)
		Spectrin 3	522..633		22/126 (17%)
		SPEC	526..746	CDD:238103	46/226 (20%)
		Spectrin 4	643..746		22/91 (24%)
		PTZ00184	753..>857	CDD:185504
		EFhand_Ca_insen	830..896	CDD:312305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810