Protein Alignment Ehbp1 and Actn2

DIOPT Version :10

• Sequence 1: NP_995865.2
• Gene: Ehbp1 / 36912
• FlyBaseID: FBgn0034180
• Length: 1141
• Species: Drosophila melanogaster
• Sequence 2: NP_150371.4
• Gene: Actn2 / 11472
• MGIID: 109192
• Length: 894
• Species: Mus musculus
• Alignment Length: 770
• Identity: 155/770 - (20%)
• Similarity: 275/770 - (35%)
• Gaps: 227/770 - (29%)

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|::..:|..:..|:|:         |.:..:.||.||:..|..|.||.:.|..|||
Mouse   116 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:..||:||...|:|||.|||:..|.:||..:..:.||. |.||::::..|:.....||:.|:
Mouse   181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAI 245

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIG-DYKSDNLSQNRINFSHPKSLLLH-------- 607
            |||:......|.|    .||..:.|:....|:. :.:::.|.:   .:....|.||.
Mouse   246 MTYVSCFYHAFAG----AEQAETAANRICKVLAVNQENERLME---EYERLASELLEWIRRTIPW 303

  Fly   608 -QNSFDEEINGSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSC 671
             :|...|      |:.|......:|.::   |..|:...||....:.:.:.|..|     ..|..
Mouse   304 LENRTPE------KTMQAMQKKLEDFRD---YRRKHKPPKVQEKCQLEINFNTLQ-----TKLRI 354

  Fly   672 QTTP---PQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARR-----LILETRVKSGG 728
            ...|   |.:          ||..|.|      |.:.:|    ||||.:     |:.|.|
Mouse   355 SNRPAFMPSE----------GKMVSDI------AGAWQR----LEQAEKGYEEWLLNEIR----- 394

  Fly   729 SIESPTRPKLERTISPIHNGAEEFYAE--------HAKKLELKEPGSPSHRLSDPKVLQSFNAIV 785
                    :|||    :.:.||:|..:        :.|:..|.:....|..|::.:.|...:...
Mouse   395 --------RLER----LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAF 447

  Fly   786 ERVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMG-----GNPSNNRRGGARN 845
            |.....|:.|.::::.|..||..|:...      |.|:..:.:.:..     |..:..||.....
Mouse   448 ESDLAAHQDRVEQIAAIAQELNELDYHD------AVNVNDRCQKICDQWDRLGTLTQKRREALER 506

  Fly   846 SNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGDEL 910
            :...|..|                                                      |:|
Mouse   507 TEKLLETI------------------------------------------------------DQL 517

  Fly   911 HTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSALSSQQSSCDNLPACS 975
            |.....|....:.::.       .....|:...:      .|.::...|.:::.:.....||
Mouse   518 HLEFAKRAAPFNNWME-------GAMEDLQDMFI------VHSIEEIQSLITAHEQFKATLP--- 566

  Fly   976 DDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQLLSQWFTLVNKKN 1040
                    .|:|...|:...|:...:..|....|   ..:.|...| .|.::|.::|..:   |.
Mouse   567 --------EADGERQSILAIQNEVEKVIQSYSIR---ISSSNPYST-VTMDELRNKWDKV---KQ 616

  Fly  1041 ALLRRQMQLNILEQEKDLERKYTMLNQELR---AAQ--SVEDWRKTEVQREKERLLLEELM---T 1097
            .:..|...|     :::|.|::.  |:.||   |||  ::..|    :|.:.|.:....:.   .
Mouse   617 LVPVRDQSL-----QEELARQHA--NERLRRQFAAQANAIGPW----IQNKMEEIARSSIQITGA 670

  Fly  1098 IVDKRDQLVQHLHN------------------QEIAIEDDQEIARKLEHVDISAE 1134
            :.|:.:||.|:.||                  ||..:.|::.....:||:.:..|
Mouse   671 LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWE 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:463058
		CH_EHBP	459..563	CDD:409047	39/104 (38%)
		bMERB_dom	<1027..1122	CDD:463467	25/120 (21%)
Actn2	NP_150371.4	Actin-binding	1..254		47/137 (34%)
		CH_ACTN_rpt1	35..139	CDD:409063	6/22 (27%)
		CH_ACTN_rpt2	143..257	CDD:409065	40/113 (35%)
		Spectrin 1	281..391		29/146 (20%)
		Spectrin	281..391	CDD:395348	29/146 (20%)
		Spectrin 2	401..506		20/110 (18%)
		SPEC	402..629	CDD:238103	45/322 (14%)
		Spectrin 3	516..627		22/146 (15%)
		Spectrin 4	637..740		20/93 (22%)
		Spectrin	637..739	CDD:395348	20/93 (22%)
		PTZ00184	747..>851	CDD:185504
		EFhand_Ca_insen	824..890	CDD:430177