Protein Alignment Ehbp1 and Ehbp1l1

DIOPT Version :10

• Sequence 1: NP_995865.2
• Gene: Ehbp1 / 36912
• FlyBaseID: FBgn0034180
• Length: 1141
• Species: Drosophila melanogaster
• Sequence 2: XP_030106561.1
• Gene: Ehbp1l1 / 114601
• MGIID: 3612340
• Length: 1730
• Species: Mus musculus
• Alignment Length: 1933
• Identity: 390/1933 - (20%)
• Similarity: 574/1933 - (29%)
• Gaps: 997/1933 - (51%)

  Fly     1 MASVWKRLQRNFKRAAKFQFTASYHDLHLETTAKWRPSNLSIVWTRRSRRVASAPLPWEPDMMNP 65
            |.||||||||..||||||||.|.||:|.||.|.||:|..|.:|||||:||:.|....|:|.:.||
Mouse     1 MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNP 65

  Fly    66 LVGNISWPVPDNHTISVTLFKDPRTHELEDKDWTFVIEDVTPMGKKRVLANASINMRKYASIEST 130
            ..|.:.|.||:|..|||||::||...:.|.|:|||:||:.: .|:::|||...:|:..:|.....
Mouse    66 YRGTVVWMVPENVDISVTLYRDPHVDQYETKEWTFIIENES-KGQRKVLATVDVNLAHHAGPVPA 129

  Fly   131 QQSFTLSLKPVSKKITAASLELTISCVFLREGKATDEDMQSVVSMMSVNNNDVAPLDDL----ED 191
            |....|.|||.|.|:..|.|.||:|.|.||||:|||:||||:.|:|||..:||..|||.    |:
Mouse   130 QVPLRLRLKPKSVKVVHAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEE 194

  Fly   192 IPDLDGFSEI--------------TDNFNDFTQQL------------------------------ 212
            ..:..|..|:              ...|.|.:::|
Mouse   195 EANGPGAPEVRTRGPQSGRGCAPRLGRFPDLSRELKTLCEEEDEGHIRPQQAAARPSSAEDTSPA 259

  Fly   213 ---------------------------------------EHMTTSLNGCIDVATP---------- 228
                                                   |..:|...|...|.||
Mouse   260 PVSAPAPPVRAFRGQGSEPAAITGGQVGPETPEPPPSPPETRSTGQPGQTMVPTPAPRLRKGSDA 324

  Fly   229 ---------QSVPSLSEDP---------------------------------------------- 238
                     ..||:.||||
Mouse   325 PSSPVPCSGDEVPNTSEDPPTGMGSSGETQAQISSQEGTEAHEARPEPDIEVRGSKDSLGGERSK 389

  Fly   239 --------------------------TPLAES--FNPLHFELDADGK------------------ 257
                                      |...|:  .:.|| ::||:.|
Mouse   390 VEEEDTGDRPGASGAGNREKNTKKSDTTAGEAGESSELH-QVDAEHKSKVQHRATEGPEAAGPTP 453

  Fly   258 ------------------------REAANKLDLP------------------------------- 267
                                    .||.:.|:.|
Mouse   454 KARLGDTPEAPPRSAQRRMGVRTQEEAPSDLNPPPAEPEEHLGDLRDARPAGQEKGSAEVRGKVP 518

  Fly   268 -------------TAASGG---------------------------------------------- 273
                         .|||.|
Mouse   519 AIGRAGPEQGSSARAASAGPQVSCVQTVPSDGQGVKSRDQRAQEAEVGESRVLETEAEWVPWEVI 583

  Fly   274 -----SSGAEESLKTPNGL-------------------------------------QHVVDQTPI 296
                 .:|..|||.|..|.                                     :.||...|.
Mouse   584 GTSKTDAGIPESLDTEAGTAESEILEAQESEAARSEGLEPEAAGTAESEVLRTQNNEIVVLGMPR 648

  Fly   297 KSPDEVKQPKQ--------------------------------------TPVESLRSKTNE---- 319
            ..| |:::|::                                      |..|.|.::..|
Mouse   649 TGP-EIREPEEFGETEVGGFTVPDTKTVIAETEILETQGVVDGEAAVLKTQAEILETQKTEAGEA 712

  Fly   320 -------------------------DFDKM-VTSTPLE--------------------------- 331
                                     :.:|: |..|.:|
Mouse   713 EAGTLESQKVAAEGLGAPEVGAEMAEAEKLGVQETEVEIWRIPRIETETAGTETLGIHKIGPPQM 777

  Fly   332 ----------------------------------------------------------------- 331
                                                                             
Mouse   778 QPRLVGDQETDVSVMETAEDAILGTREISAGCGVLLIEAKIPESKIDRSLETEEGDLGVLEVDTG 842

  Fly   332 -------------PNVNK----------------------------------------------- 336
                         |.|.|
Mouse   843 IAEAKILGIPERAPGVQKALGAGTEVARVLEAEASSSEVPETDAEEAETLQAKERSESSVALRVV 907

  Fly   337 ---------------------------------------------DDVKPKKKRA---------- 346
                                                         .|::.|.:.:
Mouse   908 ANLPESELLGTQKKVGGTGISQREVREAETEIPKTQEISSEGSGVPDLEAKMEESGRKMEIWETP 972

  Fly   347 --------LFFTEKEDE-QDLRVESVKE---DTTKT-IGD-----------NSTTKEKPKEESQS 387
                    ||.|:|..| .:|..:::|.   ||.:| :|.           .:...|..|.|:::
Mouse   973 EVEKVNSELFGTQKGSEIPELETKTIKSEILDTQETEVGGLGLRRGEAEKAEAEMLETQKTEAKT 1037

  Fly   388 SKD----------------------ASSVV----------------------------------- 395
            ::|                      |.:||
Mouse  1038 ARDEEIELVDPGVSSPEAEALRVQWAGTVVLESGEVKADILGVQKPGSWGALKYEALDVPVTKQR 1102

  Fly   396 ----------VPSAKRPELQPLNL--KKSY---------EPSQTPESAP---------------- 423
                      ||.|:.||.:.|.:  .||:         |..::||:..
Mouse  1103 LSGAKEVVPEVPRAQEPETKVLGIVEAKSWTLGQQEAEMEGFESPENKSNIFEAQEADSGVLGTM 1167

  Fly   424 --------------VPASVINESIGSCFSTSGSLNNSLKPVEKIVLKENTPG-----------QD 463
                          ..|.|.:|:.......||:  :||:..|:   ....||           |.
Mouse  1168 KGKEAVESLEEAGLSKAQVASEAGAGVPRPSGA--SSLEEPEE---DRRLPGSQAPPTLVSSSQS 1227

  Fly   464 LLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES 528
            |||||:|||..|..|.:||.|||||||:|||||:|.|.|:.||...|...::..|.:..||...:
Mouse  1228 LLEWCQEVTNGYRGVCITNFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQAFDGFAA 1292

  Fly   529 LGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQ 593
            ||:.|::||.||.:|:|||||.|||||.|:||..||::|::.|:.......:|.:|:
Mouse  1293 LGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGSGTYRVGN-------- 1349

  Fly   594 NRINFSHPKSLLLHQNSFDEEINGSNKSEQLS------PTSKKDVKNLILYNSKNILDKVLSPTK 652
                         .|.|..:.::..:.:::|.      ||..|:..|    .....:.||.|...
Mouse  1350 -------------AQPSLPDCLDAGDLAQRLREHGAEVPTEPKEAVN----RGTGAIPKVASRDT 1397

  Fly   653 DKNSINASQHANQSPMLSCQTTPPQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARR 717
            |   ::.|....::.:  .|...||:...|     |.:..||.|.:.|
Mouse  1398 D---LSCSSKDGEAEV--AQEAIPQEAPTD-----GPRARSSTTPVVP----------------- 1435

  Fly   718 LILETRVKSGGSIESPTRPKLERTISPIHNGAEEFYAEHAKKLELKEPGSPSHRLSDPKVLQSFN 782
              .|..|...|:....:..:|.|:..   ||               |.|.    :..|:...||:
Mouse  1436 --AEGLVNGVGASGGVSGVRLRRSSV---NG---------------EAGP----VPPPRAHGSFS 1476

  Fly   783 AIVERVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMGGNPSNNRRGGARNSN 847
                     |.:..|.|                                     ..||...||||
Mouse  1477 ---------HVRDADLL-------------------------------------KKRRSRLRNSN 1495

  Fly   848 PFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGDELHT 912
            .|                   ..||:.   .||..|.|.:|..:.:.....||...
Mouse  1496 SF-------------------SVDDQD---SGAAVGAGPAGPGAVEGPNPASSPDA--------- 1529

  Fly   913 RLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSA---------LSSQQSSC 968
              .|.|                .||   |.......|.|.  :||||.         ..:.|..|
Mouse  1530 --NPLP----------------APA---PQQPPGGPPPTE--ESSPSLGEETGLQRFQDTSQYVC 1571

  Fly   969 DNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQLLSQWF 1033
            ..|.|...:...:    :||||.:.:|            .||.:....|..:    ||.|:.:||
Mouse  1572 AELQALEQEQGQI----DGRAAEVEKQ------------LRSLMESGANRLQ----EEVLIQEWF 1616

  Fly  1034 TLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKERLLLEELMTI 1098
            |||||||||:|||.||.:|.:|:||||::.:|::||||..::|:|:||..|:.:|:||||||:::
Mouse  1617 TLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEEWQKTVAQQHREQLLLEELVSL 1681

  Fly  1099 VDKRDQLVQHLHNQE-IAIEDDQEIARKLE--HVDIS---AEKDKCVL 1140
            |::||:||:.|..:| ||:|:|:.:.|.||  ...:|   :.:::|.|
Mouse  1682 VNQRDELVRDLDQKERIALEEDERLERGLEQRRRKVSRQLSRRERCTL 1729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:463058	73/152 (48%)
		CH_EHBP	459..563	CDD:409047	57/114 (50%)
		bMERB_dom	<1027..1122	CDD:463467	51/95 (54%)
Ehbp1l1	XP_030106561.1	NT-C2	12..164	CDD:463058	73/152 (48%)
		PHA03307	185..>538	CDD:223039	35/353 (10%)
		CH_EHBP1L1	1223..1327	CDD:409104	55/103 (53%)
		bMERB_dom	1573..1706	CDD:463467	63/152 (41%)