DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and Ehbp1l1

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	XP_030106561.1	Gene:	Ehbp1l1 / 114601	MGIID:	3612340	Length:	1730	Species:	Mus musculus

Alignment Length:	1933	Identity:	390/1933 - (20%)
Similarity:	574/1933 - (29%)	Gaps:	997/1933 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASVWKRLQRNFKRAAKFQFTASYHDLHLETTAKWRPSNLSIVWTRRSRRVASAPLPWEPDMMNP 65
            |.||||||||..||||||||.|.||:|.||.|.||:|..|.:|||||:||:.|....|:|.:.||
Mouse     1 MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNP 65

  Fly    66 LVGNISWPVPDNHTISVTLFKDPRTHELEDKDWTFVIEDVTPMGKKRVLANASINMRKYASIEST 130
            ..|.:.|.||:|..|||||::||...:.|.|:|||:||:.: .|:::|||...:|:..:|.....
Mouse    66 YRGTVVWMVPENVDISVTLYRDPHVDQYETKEWTFIIENES-KGQRKVLATVDVNLAHHAGPVPA 129

  Fly   131 QQSFTLSLKPVSKKITAASLELTISCVFLREGKATDEDMQSVVSMMSVNNNDVAPLDDL----ED 191
            |....|.|||.|.|:..|.|.||:|.|.||||:|||:||||:.|:|||..:||..|||.    |:
Mouse   130 QVPLRLRLKPKSVKVVHAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEE 194

  Fly   192 IPDLDGFSEI--------------TDNFNDFTQQL------------------------------ 212
            ..:..|..|:              ...|.|.:::|
Mouse   195 EANGPGAPEVRTRGPQSGRGCAPRLGRFPDLSRELKTLCEEEDEGHIRPQQAAARPSSAEDTSPA 259

  Fly   213 ---------------------------------------EHMTTSLNGCIDVATP---------- 228
                                                   |..:|...|...|.||
Mouse   260 PVSAPAPPVRAFRGQGSEPAAITGGQVGPETPEPPPSPPETRSTGQPGQTMVPTPAPRLRKGSDA 324

  Fly   229 ---------QSVPSLSEDP---------------------------------------------- 238
                     ..||:.||||
Mouse   325 PSSPVPCSGDEVPNTSEDPPTGMGSSGETQAQISSQEGTEAHEARPEPDIEVRGSKDSLGGERSK 389

  Fly   239 --------------------------TPLAES--FNPLHFELDADGK------------------ 257
                                      |...|:  .:.|| ::||:.|
Mouse   390 VEEEDTGDRPGASGAGNREKNTKKSDTTAGEAGESSELH-QVDAEHKSKVQHRATEGPEAAGPTP 453

  Fly   258 ------------------------REAANKLDLP------------------------------- 267
                                    .||.:.|:.|
Mouse   454 KARLGDTPEAPPRSAQRRMGVRTQEEAPSDLNPPPAEPEEHLGDLRDARPAGQEKGSAEVRGKVP 518

  Fly   268 -------------TAASGG---------------------------------------------- 273
                         .|||.|
Mouse   519 AIGRAGPEQGSSARAASAGPQVSCVQTVPSDGQGVKSRDQRAQEAEVGESRVLETEAEWVPWEVI 583

  Fly   274 -----SSGAEESLKTPNGL-------------------------------------QHVVDQTPI 296
                 .:|..|||.|..|.                                     :.||...|.
Mouse   584 GTSKTDAGIPESLDTEAGTAESEILEAQESEAARSEGLEPEAAGTAESEVLRTQNNEIVVLGMPR 648

  Fly   297 KSPDEVKQPKQ--------------------------------------TPVESLRSKTNE---- 319
            ..| |:::|::                                      |..|.|.::..|
Mouse   649 TGP-EIREPEEFGETEVGGFTVPDTKTVIAETEILETQGVVDGEAAVLKTQAEILETQKTEAGEA 712

  Fly   320 -------------------------DFDKM-VTSTPLE--------------------------- 331
                                     :.:|: |..|.:|
Mouse   713 EAGTLESQKVAAEGLGAPEVGAEMAEAEKLGVQETEVEIWRIPRIETETAGTETLGIHKIGPPQM 777

  Fly   332 ----------------------------------------------------------------- 331

Mouse   778 QPRLVGDQETDVSVMETAEDAILGTREISAGCGVLLIEAKIPESKIDRSLETEEGDLGVLEVDTG 842

  Fly   332 -------------PNVNK----------------------------------------------- 336
                         |.|.|
Mouse   843 IAEAKILGIPERAPGVQKALGAGTEVARVLEAEASSSEVPETDAEEAETLQAKERSESSVALRVV 907

  Fly   337 ---------------------------------------------DDVKPKKKRA---------- 346
                                                         .|::.|.:.:
Mouse   908 ANLPESELLGTQKKVGGTGISQREVREAETEIPKTQEISSEGSGVPDLEAKMEESGRKMEIWETP 972

  Fly   347 --------LFFTEKEDE-QDLRVESVKE---DTTKT-IGD-----------NSTTKEKPKEESQS 387
                    ||.|:|..| .:|..:::|.   ||.:| :|.           .:...|..|.|:::
Mouse   973 EVEKVNSELFGTQKGSEIPELETKTIKSEILDTQETEVGGLGLRRGEAEKAEAEMLETQKTEAKT 1037

  Fly   388 SKD----------------------ASSVV----------------------------------- 395
            ::|                      |.:||
Mouse  1038 ARDEEIELVDPGVSSPEAEALRVQWAGTVVLESGEVKADILGVQKPGSWGALKYEALDVPVTKQR 1102

  Fly   396 ----------VPSAKRPELQPLNL--KKSY---------EPSQTPESAP---------------- 423
                      ||.|:.||.:.|.:  .||:         |..::||:..
Mouse  1103 LSGAKEVVPEVPRAQEPETKVLGIVEAKSWTLGQQEAEMEGFESPENKSNIFEAQEADSGVLGTM 1167

  Fly   424 --------------VPASVINESIGSCFSTSGSLNNSLKPVEKIVLKENTPG-----------QD 463
                          ..|.|.:|:.......||:  :||:..|:   ....||           |.
Mouse  1168 KGKEAVESLEEAGLSKAQVASEAGAGVPRPSGA--SSLEEPEE---DRRLPGSQAPPTLVSSSQS 1227

  Fly   464 LLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES 528
            |||||:|||..|..|.:||.|||||||:|||||:|.|.|:.||...|...::..|.:..||...:
Mouse  1228 LLEWCQEVTNGYRGVCITNFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQAFDGFAA 1292

  Fly   529 LGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQ 593
            ||:.|::||.||.:|:|||||.|||||.|:||..||::|::.|:.......:|.:|:
Mouse  1293 LGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGSGTYRVGN-------- 1349

  Fly   594 NRINFSHPKSLLLHQNSFDEEINGSNKSEQLS------PTSKKDVKNLILYNSKNILDKVLSPTK 652
                         .|.|..:.::..:.:::|.      ||..|:..|    .....:.||.|...
Mouse  1350 -------------AQPSLPDCLDAGDLAQRLREHGAEVPTEPKEAVN----RGTGAIPKVASRDT 1397

  Fly   653 DKNSINASQHANQSPMLSCQTTPPQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARR 717
            |   ::.|....::.:  .|...||:...|     |.:..||.|.:.|
Mouse  1398 D---LSCSSKDGEAEV--AQEAIPQEAPTD-----GPRARSSTTPVVP----------------- 1435

  Fly   718 LILETRVKSGGSIESPTRPKLERTISPIHNGAEEFYAEHAKKLELKEPGSPSHRLSDPKVLQSFN 782
              .|..|...|:....:..:|.|:..   ||               |.|.    :..|:...||:
Mouse  1436 --AEGLVNGVGASGGVSGVRLRRSSV---NG---------------EAGP----VPPPRAHGSFS 1476

  Fly   783 AIVERVSPKHEKRGDKLSYIDSELEALEREQEAIDQKASNLEAKLRAVMGGNPSNNRRGGARNSN 847
                     |.:..|.|                                     ..||...||||
Mouse  1477 ---------HVRDADLL-------------------------------------KKRRSRLRNSN 1495

  Fly   848 PFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAGSGGGRSGACSEDDDRDTSSDSVCNSGDELHT 912
            .|                   ..||:.   .||..|.|.:|..:.:.....||...
Mouse  1496 SF-------------------SVDDQD---SGAAVGAGPAGPGAVEGPNPASSPDA--------- 1529

  Fly   913 RLRPRPRSHSCFVNKNHQSTINTPAHLRPHHVHHVVPYTHMLDSSPSA---------LSSQQSSC 968
              .|.|                .||   |.......|.|.  :||||.         ..:.|..|
Mouse  1530 --NPLP----------------APA---PQQPPGGPPPTE--ESSPSLGEETGLQRFQDTSQYVC 1571

  Fly   969 DNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERRSHLCHTPNHCETEETEEQLLSQWF 1033
            ..|.|...:...:    :||||.:.:|            .||.:....|..:    ||.|:.:||
Mouse  1572 AELQALEQEQGQI----DGRAAEVEKQ------------LRSLMESGANRLQ----EEVLIQEWF 1616

  Fly  1034 TLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELRAAQSVEDWRKTEVQREKERLLLEELMTI 1098
            |||||||||:|||.||.:|.:|:||||::.:|::||||..::|:|:||..|:.:|:||||||:::
Mouse  1617 TLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEEWQKTVAQQHREQLLLEELVSL 1681

  Fly  1099 VDKRDQLVQHLHNQE-IAIEDDQEIARKLE--HVDIS---AEKDKCVL 1140
            |::||:||:.|..:| ||:|:|:.:.|.||  ...:|   :.:::|.|
Mouse  1682 VNQRDELVRDLDQKERIALEEDERLERGLEQRRRKVSRQLSRRERCTL 1729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	73/152 (48%)
		CH	460..562	CDD:237981	57/112 (51%)
		DUF3585	<1027..1122	CDD:288945	51/95 (54%)
Ehbp1l1	XP_030106561.1	NT-C2	12..164	CDD:371003	73/152 (48%)
		PHA03307	185..>538	CDD:223039	35/353 (10%)
		CH	1223..1322	CDD:366016	52/98 (53%)
		DUF3585	1570..1706	CDD:371910	64/155 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839258
Domainoid	1	1.000	180	1.000	Domainoid score	I3490
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165311at2759
OrthoFinder	1	1.000	-	-		FOG0002603
OrthoInspector	1	1.000	-	-		otm42645
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2427
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860