DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ehbp1 and Actn1

DIOPT Version :9

Sequence 1:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_001366004.1	Gene:	Actn1 / 109711	MGIID:	2137706	Length:	914	Species:	Mus musculus

Alignment Length:	785	Identity:	169/785 - (21%)
Similarity:	272/785 - (34%)	Gaps:	220/785 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487
            |||:.....|::..:|..:..|:|:         |.:..:.||.||:..|..|.||.:.|...||
Mouse   109 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISW 173

  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551
            ::|:.|||:||...|||||..||...|.:.|....||.||. |.||::::..|:.....||:.|:
Mouse   174 KDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAI 238

  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQNRINFSHPKSLLLHQNSFDEEIN 616
            |||:......|:|.| |.|                    .:.|||    .|.|.::|
Mouse   239 MTYVSSFYHAFSGAQ-KAE--------------------TAANRI----CKVLAVNQ-------- 270

  Fly   617 GSNKSEQLSPTSKKDVKNLILY--------------NSKNILDKVLSPTKDKNSINASQHANQSP 667
               ::|||....:|...:|:.:              |:.:.:.:.|...:|...::......:..
Mouse   271 ---ENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKC 332

  Fly   668 MLSCQTTPPQDESLDKGSQPG--GKENSSITTIDP-----QAASEERQQRLLEQARRL----ILE 721
            .|.......|.: |...::|.  ..|...::.|:.     :.|.:..::.||.:.|||    .|.
Mouse   333 QLEINFNTLQTK-LRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLA 396

  Fly   722 TRVKSGGSI--------ESPTRPK--LERTISPI------HNGAEEFYAEHAKKLELKEPGSPSH 770
            .:.:...||        |:..|.|  ...|:|.|      |...|...|.|..::|
Mouse   397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVE--------- 452

  Fly   771 RLSDPKVLQSFNAIVERVSPKHEKRGDKL--------SYIDSELEALEREQ---EAIDQKASNLE 824
              ....:.|..|.:....||....|..|:        :......|||||.:   |.|||  ..||
Mouse   453 --QIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQ--LYLE 513

  Fly   825 AKLRAVMGGNPSNNRRGGARN--SNPFLRLIRNSIGG----GDVIRIKLLDSDDESLFGGGAGSG 883
            ...||.    |.||...||..  .:.|:......|.|    .:..:..|.|:|.|.|...|
Mouse   514 YAKRAA----PFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILG---- 570

  Fly   884 GGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRS-HSCFVNKNHQSTINTPAHL--RPHHVH 945
                                      :|..:....:: |......|..:|| ||..:  :..||.
Mouse   571 --------------------------IHNEVSKIVQTYHVNMAGTNPYTTI-TPQEINGKWDHVR 608

  Fly   946 HVVPYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQ------ 1004
            .:||      ....||:.:.:                           |||...|.|:|
Mouse   609 QLVP------RRDQALTEEHA---------------------------RQQHNERLRKQFGAQAN 640

  Fly  1005 --------RRERRSHLCHTPNHCETEETEEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLERK 1061
                    :.|....: ....|...|:....|.....::||.|..:.:.:....::::....:.|
Mouse   641 VIGPWIQTKMEEIGRI-SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNK 704

  Fly  1062 YTMLNQE-LRAAQSVEDWRKTEVQREKERLLLEELMTIVDKRDQLVQHLHNQEIAIEDDQEIARK 1125
            :|..|.| :|..     |         |:||.....||.:..:|::.. ..:.|:.|...|....
Mouse   705 HTNYNMEHIRVG-----W---------EQLLTTIARTINEVENQILTR-DAKGISQEQMNEFRAS 754

  Fly  1126 LEHVD 1130
            ..|.|
Mouse   755 FNHFD 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	40/102 (39%)
		DUF3585	<1027..1122	CDD:288945	18/95 (19%)
Actn1	NP_001366004.1	CH_ACTN_rpt1	28..132	CDD:409063	6/22 (27%)
		CH_ACTN_rpt2	136..250	CDD:409065	41/113 (36%)
		SPEC	277..498	CDD:238103	39/232 (17%)
		SPEC	395..622	CDD:238103	60/280 (21%)
		Spectrin	634..733	CDD:395348	19/113 (17%)
		EFh	750..839	CDD:238008	3/10 (30%)
		EFhand_Ca_insen	844..910	CDD:400872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810