DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6805 and Inppl1

DIOPT Version :9

Sequence 1:	NP_611178.1	Gene:	CG6805 / 36911	FlyBaseID:	FBgn0034179	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_075233.1	Gene:	Inppl1 / 65038	RGDID:	68396	Length:	1257	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	108/367 - (29%)
Similarity:	168/367 - (45%)	Gaps:	72/367 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LCIFLLTWNVGTHTPRNQDLSSLLSLNG--------TTTCPDNQLPDIYVIGFQEVSTTPQVLKI 66
            :.:|:.|||:|: .|..::::|..:..|        |.|.|.    ||||.|.||.|.
  Rat   425 ISVFIGTWNMGS-VPPPKNVTSWFTSKGLGKALDEVTVTIPH----DIYVFGTQENSV------- 477

  Fly    67 FNDDPWV------LKIADSLSDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGL 125
             .|..|:      ||   .|:|..:..:..:.|..|.:.:..:.:|...:..:.|.:.:||:...
  Rat   478 -GDREWLDLLRGGLK---ELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANT 538

  Fly   126 WGNKGAVSIRLSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKYNAQGYRRI--------F 182
            .||||||.:.....||...||..||.:.:||...|.::|..|:   :..:.|.|::        |
  Rat   539 LGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDIL---RLLSLGDRQLSAFDISLRF 600

  Fly   183 DHDFVFWFGDLNFRLSGDMSAWDVRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPT 247
            .|  :|||||||:||  ||...::...:..:.:..||::|||||.|||...|....|::.:|.||
  Rat   601 TH--LFWFGDLNYRL--DMDIQEILNYISRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT 661

  Fly   248 FKFVEGTND-YNLKRR---------PAWCDRILHRVQSNIYPGITLSANQLSYQSHMDYTLSDHK 302
            :::..|:.| |...::         |:||||||.:    .||...:..|  ||....|...|||.
  Rat   662 YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWK----SYPETHIICN--SYGCTDDIVTSDHS 720

  Fly   303 PVSATFNYKV-----------EAANQTYTDEELHEMTHGSAS 333
            ||..||...|           :.::|.|.:.|..|....:||
  Rat   721 PVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTAS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6805	NP_611178.1	EEP	12..308	CDD:294334	99/327 (30%)
Inppl1	NP_075233.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	101/331 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986
		SH3-binding	945..950
		NPXY motif	984..987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1115
		SAM_Ship2	1193..1255	CDD:188890
		SAM	1201..1257	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810