DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6805 and INPP5E

DIOPT Version :9

Sequence 1:	NP_611178.1	Gene:	CG6805 / 36911	FlyBaseID:	FBgn0034179	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_063945.2	Gene:	INPP5E / 56623	HGNCID:	21474	Length:	644	Species:	Homo sapiens

Alignment Length:	352	Identity:	97/352 - (27%)
Similarity:	147/352 - (41%)	Gaps:	70/352 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLCIFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLP-------DIYVIGFQEVSTTPQVLKI 66
            ::.:|:.|||:.........|...|            ||       |:||||.||..:..:
Human   298 NVALFVATWNMQGQKELPPSLDEFL------------LPAEADYAQDLYVIGVQEGCSDRR---- 346

  Fly    67 FNDDPWVLKIADSLSDHQFVKVDSKQLQGIL-ITMFAQHKHIPHMKEIETEATRTGLGGLWGNKG 130
                .|..::.::|..|..:.  |....|:| :::|.:...|....|:|.....|.:......||
Human   347 ----EWETRLQETLGPHYVLL--SSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKG 405

  Fly   131 AVSIRLSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIV----------DNHKYNAQGYRRIFDHD 185
            |:.|..:.:||...|:.||..:.|.|:.||:.||.:.|          |.:.|.:.........|
Human   406 ALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFD 470

  Fly   186 FVFWFGDLNFRLSGDMSAWD------VRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNF 244
            .||||||.||||||..:..|      :..||     ..||:.|||.....||:.|...:|...:|
Human   471 EVFWFGDFNFRLSGGRTVVDALLCQGLVVDV-----PALLQHDQLIREMRKGSIFKGFQEPDIHF 530

  Fly   245 APTFKFVEGTNDY---NLKRRPAWCDRILHRV--QSNIYPGITLSANQLSYQSHMDYTLSDHKPV 304
            .|::||..|.:.|   :.:|.|::.||:|:|.  :.:|.|        :||.|......|||:||
Human   531 LPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICP--------VSYSSCPGIKTSDHRPV 587

  Fly   305 SATFNYKVEAANQTYT------DEELH 325
            ...|..||........      |.||:
Human   588 YGLFRVKVRPGRDNIPLAAGKFDRELY 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6805	NP_611178.1	EEP	12..308	CDD:294334	91/324 (28%)
INPP5E	NP_063945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..193
		PHA03247	<2..179	CDD:223021
		13 X 4 AA repeats of P-X-X-P	10..242
		INPP5c_INPP5E-like	295..593	CDD:197329	92/329 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810