DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6805 and INPP5K

DIOPT Version :9

Sequence 1:	NP_611178.1	Gene:	CG6805 / 36911	FlyBaseID:	FBgn0034179	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_057616.2	Gene:	INPP5K / 51763	HGNCID:	33882	Length:	448	Species:	Homo sapiens

Alignment Length:	378	Identity:	130/378 - (34%)
Similarity:	201/378 - (53%)	Gaps:	49/378 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LCIFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFND----D 70
            |.|.::||||.:..| ..|||.||.||..     |...||||||.||:::  .::.:.:|    |
Human    14 LSIHVVTWNVASAAP-PLDLSDLLQLNNR-----NLNLDIYVIGLQELNS--GIISLLSDAAFND 70

  Fly    71 PWVLKIADSLSDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNKGAVSIR 135
            .|...:.|.||...|:||...::||||:.:||:::|:|:::.:.|::|.|||.|.|||||.|:|.
Human    71 SWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNIC 135

  Fly   136 LSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKYNAQGYRRIFDHDFVFWFGDLNFRLSGD 200
            |.|||..|:.:..||..|.....:|:|.:.:|::......:....|.|||.:.||||:|||:. |
Human   136 LKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIE-D 199

  Fly   201 MSAWDVRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTNDYNL---KRR 262
            .....||..::|:.|..|.:.|||::.::........:|.:..|.||:||...:|||:.   ||:
Human   200 FGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRK 264

  Fly   263 PAWCDRILHRVQ--------SNIYPGITLSANQLSYQSHMDYTLSDHKPVSATFNYKVE------ 313
            |||.||||.|::        :.|.|....|.:...|.|||.|.:|||||||.||:.:::
Human   265 PAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAP 329

  Fly   314 ----AANQTYTDEELHEMTHGSASS-PATP--------------NVSLSFAFV 347
                .....:|.|....:::.|.|. |::|              |..:|:|:|
Human   330 LIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWV 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6805	NP_611178.1	EEP	12..308	CDD:294334	117/310 (38%)
INPP5K	NP_057616.2	EEP	14..320	CDD:382041	120/314 (38%)
		Catalytic. /evidence=ECO:0000255	16..318		117/310 (38%)
		Required for interaction with GPR78 and PAK1. /evidence=ECO:0000269\|PubMed:26940976	318..448		11/65 (17%)
		Required for ruffle localization	321..448		10/62 (16%)
		SKICH	331..431	CDD:375315	10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146099
Domainoid	1	1.000	210	1.000	Domainoid score	I2816
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3579
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46410
OrthoDB	1	1.010	-	-		D336369at33208
OrthoFinder	1	1.000	-	-		FOG0001973
OrthoInspector	1	1.000	-	-		mtm8545
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5114
SonicParanoid	1	1.000	-	-		X1469
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900