Protein Alignment CG6805 and INPP5B

DIOPT Version :10

• Sequence 1: NP_611178.1
• Gene: CG6805 / 36911
• FlyBaseID: FBgn0034179
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_005531.2
• Gene: INPP5B / 3633
• HGNCID: 6077
• Length: 913
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 122/367 - (33%)
• Similarity: 183/367 - (49%)
• Gaps: 33/367 - (8%)

  Fly     5 TAIADLCIFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFND 69
            |.|.:...|..|:||...:|: :.|...|| ||.      |.||:|.:||||:..:.:.. .|:|
Human   260 TYIQNFRFFAGTYNVNGQSPK-ECLRLWLS-NGI------QAPDVYCVGFQELDLSKEAF-FFHD 315

  Fly    70 DP----WVLKIADSL-SDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNK 129
            .|    |...:::.| .|.::.||...:|.||::.::.:.:|..::.|:|.|...||:.|..|||
Human   316 TPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNK 380

  Fly   130 GAVSIRLSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKY----NAQGYRRIFDHDFVFWF 190
            |.|:||...:.|.:..|.||||||.|:.:.|.:||..|....::    .:.....|.:||.:.|.
Human   381 GGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWL 445

  Fly   191 GDLNFRLSGDMSAWDVRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTN 255
            ||||:|:. ::....|:..:|.:.:..|...|||.:.......|....|.:..|.||:|:..|::
Human   446 GDLNYRIE-ELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSD 509

  Fly   256 DYNLK---RRPAWCDRILHRVQSNIYPGITLSANQLSYQSHMDYTLSDHKPVSATFNYKVEAANQ 317
            |::..   |.||||||||.: ..||        .||||||||....|||||||:.|:..|...|.
Human   510 DWDTSEKCRAPAWCDRILWK-GKNI--------TQLSYQSHMALKTSDHKPVSSVFDIGVRVVND 565

  Fly   318 TYTDEELHEMTHG--SASSPATPNVSLSFAFVVFVAVSYTQL 357
            ....:.|.|:...  ...:...|:||||.....|..|.|.||
Human   566 ELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQL 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6805	NP_611178.1	EEP	12..308	CDD:469791	105/307 (34%)
INPP5B	NP_005531.2	INPP5B_PH	1..146	CDD:465268
		INPP5c_INPP5B	265..558	CDD:197327	106/311 (34%)
		RhoGAP_OCRL1	692..912	CDD:239845