DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6805 and Inpp5k

DIOPT Version :9

Sequence 1:	NP_611178.1	Gene:	CG6805 / 36911	FlyBaseID:	FBgn0034179	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	XP_006532570.1	Gene:	Inpp5k / 19062	MGIID:	1194899	Length:	472	Species:	Mus musculus

Alignment Length:	323	Identity:	116/323 - (35%)
Similarity:	183/323 - (56%)	Gaps:	33/323 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LCIFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFND----D 70
            |.:.::||||.:..| ..|||.||.||.    .|..| |||:||.||::.  .::.:.:|    |
Mouse    32 LSVHVVTWNVASAAP-TVDLSDLLQLNN----QDLNL-DIYIIGLQEMNF--GIISLLSDAAFED 88

  Fly    71 PWVLKIADSLSDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNKGAVSIR 135
            ||.....|.||...|||:...::||:|:.:||:::|:|:::.|.|::|.|||.|.|||||.|::.
Mouse    89 PWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVC 153

  Fly   136 LSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKYNAQGYRRIFDHDFVFWFGDLNFRLSGD 200
            |.|||..|:.:..||..|.....:|:|.:.:|:::..:.......|.|||.:.||||:|||:. |
Mouse   154 LKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIE-D 217

  Fly   201 MSAWDVRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTNDYNL---KRR 262
            .....|:..:..:.|.:|.:.|||.:.::........:|....|.||:||...:|:|:.   ||:
Mouse   218 FGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRK 282

  Fly   263 PAWCDRILHRVQ----------SNI---YPGITLSANQLSYQSHMDYTLSDHKPVSATFNYKV 312
            |||.||||.|::          |::   |..:||.    :|.|||.|::||||||:.||:.::
Mouse   283 PAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLK----NYVSHMAYSISDHKPVTGTFDLEL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6805	NP_611178.1	EEP	12..308	CDD:294334	113/315 (36%)
Inpp5k	XP_006532570.1	EEP	32..339	CDD:382041	116/319 (36%)
Inpp5k	XP_006532570.1	SKICH	350..454	CDD:375315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836198
Domainoid	1	1.000	207	1.000	Domainoid score	I2871
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3490
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46410
OrthoDB	1	1.010	-	-		D336369at33208
OrthoFinder	1	1.000	-	-		FOG0001973
OrthoInspector	1	1.000	-	-		mtm8773
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5114
SonicParanoid	1	1.000	-	-		X1469
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.900