DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6805 and Inpp5j

DIOPT Version :9

Sequence 1:NP_611178.1 Gene:CG6805 / 36911 FlyBaseID:FBgn0034179 Length:357 Species:Drosophila melanogaster
Sequence 2:NP_598246.1 Gene:Inpp5j / 171088 RGDID:620541 Length:1001 Species:Rattus norvegicus


Alignment Length:317 Identity:125/317 - (39%)
Similarity:187/317 - (58%) Gaps:33/317 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFND----DPW 72
            |.::||||||..|.: |::|||.|.|.   .|:...|:..||.|||::  .:.|...|    |.|
  Rat   420 ITVVTWNVGTAMPPD-DVTSLLHLGGG---HDSDGADMIAIGLQEVNS--MINKRLKDALFTDQW 478

  Fly    73 VLKIADSLSDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNKGAVSIRLS 137
            .....|:|....||.|.:.::||:::.:||::.|:|.:::::|:.|||||||.|||||.||:||:
  Rat   479 SELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLA 543

  Fly   138 LYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKYNAQGYRRIFDHDFVFWFGDLNFRLSGDMS 202
            .:|..:.|:..||.||.:|.::|.:::..|:...::...|...|.|||.||||||||||:    .
  Rat   544 AFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRI----E 604

  Fly   203 AWD---VRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTNDYNL---KR 261
            ::|   |:..:::.:...|.:.||||:.:.........:|...||||||||..|||.|:.   ||
  Rat   605 SYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKR 669

  Fly   262 RPAWCDRILHRVQSNIYP----------GITLSANQLSYQSHMDYTLSDHKPVSATF 308
            :|||.||||.:|::   |          ...|...|.||:|||:||:||||||:|.|
  Rat   670 KPAWTDRILWKVKA---PSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAARF 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6805NP_611178.1 EEP 12..308 CDD:294334 124/315 (39%)
Inpp5jNP_598246.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..130
RSXSXX motif 1 6..11
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..412
SH3-binding. /evidence=ECO:0000255 346..351
RSXSXX motif 2 351..356
INPP5c_INPP5J-like 418..725 CDD:197328 125/317 (39%)
Catalytic. /evidence=ECO:0000255 420..723 124/315 (39%)
Required for ruffle localization. /evidence=ECO:0000250 724..835 125/317 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 837..1001
RSXSXX motif 3 869..874
RSXSXX motif 4 880..885
RSXSXX motif 5 906..911
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166339879
Domainoid 1 1.000 207 1.000 Domainoid score I2785
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8682
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D336369at33208
OrthoFinder 1 1.000 - - FOG0001973
OrthoInspector 1 1.000 - - mtm9020
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11200
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1469
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.810

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