DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6805 and Inpp5j

DIOPT Version :10

Sequence 1:NP_611178.1 Gene:CG6805 / 36911 FlyBaseID:FBgn0034179 Length:357 Species:Drosophila melanogaster
Sequence 2:NP_766027.2 Gene:Inpp5j / 170835 MGIID:2158663 Length:1003 Species:Mus musculus


Alignment Length:317 Identity:125/317 - (39%)
Similarity:187/317 - (58%) Gaps:33/317 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFND----DPW 72
            |.::||||||..|.: |::|||.|.   :..||...|:..||.|||::  .:.|...|    |.|
Mouse   422 ITVVTWNVGTAMPPD-DVTSLLHLG---SGHDNDGADMIAIGLQEVNS--MINKRLKDALFTDQW 480

  Fly    73 VLKIADSLSDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNKGAVSIRLS 137
            .....|:|....||.|.:.::||:::.:||::.|:|.:::::|:.|||||||.|||||.||:||:
Mouse   481 SELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLA 545

  Fly   138 LYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKYNAQGYRRIFDHDFVFWFGDLNFRLSGDMS 202
            .:|..:.|:..||.||.:|.::|.:::..|:...::...|...|.|||.||||||||||:    .
Mouse   546 AFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRI----E 606

  Fly   203 AWD---VRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTNDYNL---KR 261
            ::|   |:..:::.:...|.:.||||:.:.........:|...||||||||..|||.|:.   ||
Mouse   607 SYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKR 671

  Fly   262 RPAWCDRILHRVQSNIYP----------GITLSANQLSYQSHMDYTLSDHKPVSATF 308
            :|||.||||.:|::   |          ...|...|.||:|||:||:||||||:|.|
Mouse   672 KPAWTDRILWKVKA---PSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQF 725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6805NP_611178.1 EEP 12..308 CDD:469791 124/315 (39%)
Inpp5jNP_766027.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..110
RSXSXX motif 1 6..11
PHA03247 <50..337 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..414
SH3-binding. /evidence=ECO:0000255 346..351
RSXSXX motif 2 351..356
INPP5c_INPP5J-like 420..727 CDD:197328 125/317 (39%)
Catalytic. /evidence=ECO:0000255 422..725 124/315 (39%)
Required for ruffle localization 726..837 125/317 (39%)
SKICH 738..836 CDD:465482
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..1003
RSXSXX motif 3 871..876
RSXSXX motif 4 882..887
RSXSXX motif 5 908..913
Blue background indicates that the domain is not in the aligned region.

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