DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6805 and Inpp5b

DIOPT Version :9

Sequence 1:	NP_611178.1	Gene:	CG6805 / 36911	FlyBaseID:	FBgn0034179	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	XP_006502867.1	Gene:	Inpp5b / 16330	MGIID:	103257	Length:	994	Species:	Mus musculus

Alignment Length:	367	Identity:	122/367 - (33%)
Similarity:	185/367 - (50%)	Gaps:	33/367 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TAIADLCIFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFND 69
            |.|.:...|:.|:||...:|: :.|...||.:...       ||:|.:||||:..:.:.. .|:|
Mouse   341 TYIQNFRFFVGTYNVNGQSPK-ECLRPWLSHSALA-------PDVYCVGFQELDLSKEAF-FFHD 396

  Fly    70 DP----WVLKIADSL-SDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNK 129
            .|    |...:::|| .|.::.||...:|.||::.::.:.:|..::.|:|.|...||:.|..|||
Mouse   397 TPKEEEWFKAVSESLHPDAKYAKVKFVRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNK 461

  Fly   130 GAVSIRLSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKY----NAQGYRRIFDHDFVFWF 190
            |.|:||..|:.|.:..|.||||||.|:.:.|.:||..|....::    .:|....|..||.:.|.
Mouse   462 GGVAIRFQLHNTSICVVNSHLAAHTEEYERRNQDYRDICSRMQFPQVDPSQPPLTINKHDVILWL 526

  Fly   191 GDLNFRLSGDMSAWDVRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTN 255
            ||||:|:. ::....|:..||.:.:..|...|||.:.......|....|.:..|.||:|:..|::
Mouse   527 GDLNYRIE-ELDVGKVKKLVEEKAFQTLYAHDQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSD 590

  Fly   256 DYNLK---RRPAWCDRILHRVQSNIYPGITLSANQLSYQSHMDYTLSDHKPVSATFNYKVEAANQ 317
            |::..   |.||||||||.: ..||        .||||||||....|||||||:.|:..|...|:
Mouse   591 DWDTSEKCRAPAWCDRILWK-GKNI--------TQLSYQSHMALKTSDHKPVSSVFDIGVRVVNE 646

  Fly   318 TYTDEELHEMTHG--SASSPATPNVSLSFAFVVFVAVSYTQL 357
            ....:.|.|:...  ...:...|:|:||.....|..|.|.||
Mouse   647 ELYRKTLEEIVRSLDKMENANIPSVTLSKREFCFENVKYMQL 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6805	NP_611178.1	EEP	12..308	CDD:294334	106/307 (35%)
Inpp5b	XP_006502867.1	INPP5B_PH	1..150	CDD:374793
		INPP5c_INPP5B	346..639	CDD:197327	107/311 (34%)
		RhoGAP_OCRL1	773..991	CDD:239845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810