DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITGB4 and Itgbn

DIOPT Version :9

Sequence 1:	XP_006721929.1	Gene:	ITGB4 / 3691	HGNCID:	6158	Length:	1910	Species:	Homo sapiens
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	227/799 - (28%)
Similarity:	366/799 - (45%)	Gaps:	124/799 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    38 GPRPSPWARLL-LAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFR-DRRCNTQA 100
            |.|...|..|: |.|.||.|.:.::.::|:.|  .||..|:....:||:|||:.:: ..||.::.
  Fly     5 GGRAFLWIYLVFLIAEISHSDADSIDDQCRHA--DSCERCLSAHLECAWCTDKEYQVGYRCLSRR 67

Human   101 ELLAAGCQRESIVVMESSFQITEETQI---DTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLE 162
            :||...|....|...:....:.::..:   :|:.:..|::||...::|..|..:..:|.......
  Fly    68 QLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARN 132

Human   163 SPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKE 227
            :|:|||:|||.:.:|.||...|:::|..|::.|..||.:|.:|||.|.||.::|.  :.|:..:.
  Fly   133 NPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPM--ILPQHREN 195

Human   228 PW----PNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRP 288
            |.    ...:|.:.:::.:|||:|:..|.:.:...:|:||||..|||.||::|..|||::|||:.
  Fly   196 PCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKE 260

Human   289 DSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHN 353
            .:..:::..|:...|...||  :||||:.|||::|||:..|.||.....||||:..:.|.|.:..
  Fly   261 QARKVVILVTDGFMHLAGDG--LLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRK 323

Human   354 IIPIFAVTNYSYSYYEKLHTYF-PVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLR 417
            |..|||||....|.|.:|.... .:|.:.:|..|||||:||:::::..:...... |.:||
  Fly   324 INVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSP---- 383

Human   418 TEVTSKMFQKTRTGSF----------HIRRGEVGIYQVQLRALEHVDG---THVCQLPEDQKGNI 469
             :.....:.....|.|          ::..|:...:.|.:...::.|.   ||..::.|
  Fly   384 -DFIDMAYYTDCGGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEE------ 441

Human   470 HLKPSFSDGLKMDAGIICDVCTC----ELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTG 530
               .|.|:.:.:|.. :...|.|    :.:.|.....|.:.|...||.|.|.|||:|..|||.|.
  Fly   442 ---TSLSEFMDLDVE-LQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTD 502

Human   531 SLSD------IQPCLREGEDKP-----CSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGF 584
            :.:.      :|.|.:...||.     ||..|:|.||.|:|  :..|.|.|||..  :|     .
  Fly   503 ATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLC--DPGYTGPFCECR--EC-----L 558

Human   585 LCNDR-GRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTI 648
            .|::: ..|..|||||:.||:|..|:|......|:...|.||:.||.|:|..|.|.:.  |....
  Fly   559 DCDEKLADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP--YLGKF 621

Human   649 CEINYSAIHPGLCEDLRSCVQC---QAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRD 710
            |||:....:. ||.....||.|   |..|.|     .||...             |:   ||..|
  Fly   622 CEIDPEKDNK-LCLFYEPCVTCLIEQKQGMG-----VCENLT-------------EI---CSSLD 664

Human   711 EDDDCTYSYTMEGDGAPG-----------------------PNSTVLVHKKKDCPPGSFWWL--- 749
            ..:...|::..|.|....                       .:|..|..:..||.|..:..|
  Fly   665 RQETYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDCEPPDYVALVGY 729

Human   750 IPLLLLLLPLLALLLLLCW 768
            |....||:.||.:.::| |
  Fly   730 ISAFTLLIGLLIIFIIL-W 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITGB4	XP_006721929.1	Integrin_beta	72..488	CDD:278776	125/437 (29%)
		EGF_2	578..608	CDD:285248	11/30 (37%)
		Integrin_B_tail	661..744	CDD:285239	20/108 (19%)
		Calx-beta	1025..1119	CDD:281194
		fn3	1163..1243	CDD:278470
		FN3	1255..1348	CDD:238020
		fn3	1617..1699	CDD:278470
		fn3	1730..1815	CDD:278470
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	126/441 (29%)
		EGF_2	524..552	CDD:285248	10/29 (34%)
		Integrin_b_cyt	748..785	CDD:285884	227/799 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159897
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810