DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AsnRS-m and NARS1

DIOPT Version :9

Sequence 1:	NP_611176.1	Gene:	AsnRS-m / 36909	FlyBaseID:	FBgn0034177	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_004530.1	Gene:	NARS1 / 4677	HGNCID:	7643	Length:	548	Species:	Homo sapiens

Alignment Length:	458	Identity:	119/458 - (25%)
Similarity:	202/458 - (44%)	Gaps:	59/458 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GDSLAIQGWIKNVRRL-KNNTFLDINDGSTSSRFQVVVP----RTPENQHLAPGSVIAAVGKIQV 83
            |..:.:.||:..:||. ||..||.:.||  :...|.|:.    :......|:..|.:|..|.:.:
Human   125 GQRVKVFGWVHRLRRQGKNLMFLVLRDG--TGYLQCVLADELCQCYNGVLLSTESSVAVYGMLNL 187

  Fly    84 APN-----GSFELHANQVEML-------AEGRLQEGYPFSPKQKHPPEYVREHLHLRSRVDFVAA 136
            .|.     |..||..:..|::       |:..:.|        :...:....:.|:..|.:.::.
Human   188 TPKGKQAPGGHELSCDFWELIGLAPAGGADNLINE--------ESDVDVQLNNRHMMIRGENMSK 244

  Fly   137 QMRVRHKAQKAIHDYMDDQDFVQINTPLLTTNDCEGAGEVFRVQPDSQDLLKQMNRPNIPMEQSY 201
            .::.|....:...|:..|:.:.::..|.|.....||...:|::                    .|
Human   245 ILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKL--------------------DY 289

  Fly   202 FDSKVFLSVSGQLHLEAMTYGLGKTYTLSPAFRAENSKSPLHLAEFYMFEAELAHLEEMEKLAQF 266
            |..:.||:.|.||:||.....||..:.::.::|||.|::..||||:...|||...| ..:.|...
Human   290 FGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFL-TFDDLLNR 353

  Fly   267 IEQMLKSVTNRLLETSGEDLSFCQRNSNSNSDLPWLQVPWKIMSYDEALQVLQEN--KDSLKTPI 329
            :|.::..|.:|:|::....:   ....|.|...|  :.|:|.|:|.:|:..|:|:  |....|..
Human   354 LEDLVCDVVDRILKSPAGSI---VHELNPNFQPP--KRPFKRMNYSDAIVWLKEHDVKKEDGTFY 413

  Fly   330 SLNEGFSKDQELFLVAHCGAPVFVVDWPAQQKPFYMKVSRSNPNRVHALDLLMPAVGELCGGSLR 394
            ...|...:..|..:......|:.:..:|.:.|.|||:....:.....::|:|||.|||:.|||:|
Human   414 EFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMR 478

  Fly   395 ESD-PAILKSHPHL---PKDLEWYVDLRKYGGVPTGGFGMGFERYLQLVTGVKNIRDVIPFPRYP 455
            ..| ..||..:...   |....||.|.||||..|.||:|:|.||:|..:....:||||..:||:.
Human   479 IFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPRFV 543

  Fly   456 HSC 458
            ..|
Human   544 QRC 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnRS-m	NP_611176.1	asnC	13..460	CDD:235176	119/458 (26%)
		EcAsnRS_like_N	27..101	CDD:239813	21/90 (23%)
		AsxRS_core	115..456	CDD:238399	94/346 (27%)
NARS1	NP_004530.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..91
		AsnS	125..548	CDD:223096	119/458 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820