DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ste24a and STE24

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_012651.1	Gene:	STE24 / 853581	SGDID:	S000003878	Length:	453	Species:	Saccharomyces cerevisiae

Alignment Length:	475	Identity:	171/475 - (36%)
Similarity:	261/475 - (54%)	Gaps:	55/475 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DADTVL--------LSILFLVVIENALEIYISLRQVKVYQ--TALKVPAELKSHMGEDTFHKARK 59
            |..|:|        |.|....:.:.:.|.|::.||   ||  :..|:|..|:..:.::||||:|.
Yeast     3 DLKTILDHPNIPWKLIISGFSIAQFSFESYLTYRQ---YQKLSETKLPPVLEDEIDDETFHKSRN 64

  Fly    60 YGLDQEKFGIFKAVVMDVALLCMELYI---GLIAVLWQLSVQVVD---KLQWDSKNEIIVSCVFV 118
            |...:.||.||.    ||..|..:|..   .|...:|.::|.:::   .:::...:.:..|..|:
Yeast    65 YSRAKAKFSIFG----DVYNLAQKLVFIKYDLFPKIWHMAVSLLNAVLPVRFHMVSTVAQSLCFL 125

  Fly   119 LISNVLSTFKGLPFKIYKIFVLEETHGFNKQTARFFAWDQLKGFLVTQVLMIPITAAIIFIVQRG 183
            .:.:.|||...||...|..|||||..||||.|.:.:..|.:|...:...:..||....:.|..:.
Yeast   126 GLLSSLSTLVDLPLSYYSHFVLEEKFGFNKLTVQLWITDMIKSLTLAYAIGGPILYLFLKIFDKF 190

  Fly   184 GDNFFIWLWIFTGVISLVLLTLYPIFIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTKLFVVEG 248
            ..:|..::.:|..|:.::.:|:.|:||.|:|:|:||||.|.|::|||.||..:.|||.|:||::|
Yeast   191 PTDFLWYIMVFLFVVQILAMTIIPVFIMPMFNKFTPLEDGELKKSIESLADRVGFPLDKIFVIDG 255

  Fly   249 SKRSSHSNAYFYGL-WNSKRIVLFDTLLLNKGKPDDSELSEEEKGKGCTDEEVLAVLGHELGHWK 312
            |||||||||||.|| :.||||||||| |:|....|                |:.|||.||:|||:
Yeast   256 SKRSSHSNAYFTGLPFTSKRIVLFDT-LVNSNSTD----------------EITAVLAHEIGHWQ 303

  Fly   313 LGHVTKNIIIMQVHLFLMFLVFGNVFKYPPFYVAMGF--QPGTR-----------PILVGLLIVF 364
            ..|:...:|..|:|.||:|.:|.::::...||...||  :..|.           ||::|.:: |
Yeast   304 KNHIVNMVIFSQLHTFLIFSLFTSIYRNTSFYNTFGFFLEKSTGSFVDPVITKEFPIIIGFML-F 367

  Fly   365 TYVLAPYNALMNFAMTILSRRFEYQADEFAFKLGFAEQLGQALIKLNVDNLGFPVYDWLYSTWNH 429
            ..:|.|....|.|.|:::||..|||||.:|.|||:.:.|.:|||.|.:.||.....|.|||::::
Yeast   368 NDLLTPLECAMQFVMSLISRTHEYQADAYAKKLGYKQNLCRALIDLQIKNLSTMNVDPLYSSYHY 432

  Fly   430 SHPTLLQRLNRLKELKEEKK 449
            |||||.:||..|..:.|:||
Yeast   433 SHPTLAERLTALDYVSEKKK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	55/192 (29%)
		HtpX	153..440	CDD:223575	118/300 (39%)
		Peptidase_M48	219..439	CDD:279743	101/233 (43%)
STE24	NP_012651.1	M48A_Zmpste24p_like	17..446	CDD:320702	165/453 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344115
Domainoid	1	1.000	179	1.000	Domainoid score	I716
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	277	1.000	Inparanoid score	I575
Isobase	1	0.950	-	0	Normalized mean entropy	S1184
OMA	1	1.010	-	-		QHG61664
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		otm46568
orthoMCL	1	0.900	-	-		OOG6_101632
Panther	1	1.100	-	-	LDO	PTHR10120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1406
SonicParanoid	1	1.000	-	-		X3698
TreeFam	1	0.960	-	-
	16	15.740