DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24a and ATSTE24

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_567212.1	Gene:	ATSTE24 / 828209	AraportID:	AT4G01320	Length:	424	Species:	Arabidopsis thaliana

Alignment Length:	445	Identity:	189/445 - (42%)
Similarity:	275/445 - (61%)	Gaps:	37/445 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SILFLVVIENALEIYISLRQVKVYQTALKVPAELKSHMG---EDTFHKARKYGLDQEKFGI---F 70
            :::..:::....|.|:.|||:    ||||:|...|:.:|   ::.|.|:|.|.||:..|..   |
plant     8 TVVGFMIVMYIFETYLDLRQL----TALKLPTLPKTLVGVISQEKFEKSRAYSLDKSYFHFVHEF 68

  Fly    71 KAVVMDVALLCMELYIGLIAVLWQLSVQVVDKLQWDSKNEIIVSCVFVLISNVLSTFKGLPFKIY 135
            ..::||.|:    |:.|::...|::|..|:.:|..|.:|||:.:..|:......|....|||.:|
plant    69 VTILMDSAI----LFFGILPWFWKMSGAVLPRLGLDPENEILHTLSFLAGVMTWSQITDLPFSLY 129

  Fly   136 KIFVLEETHGFNKQTARFFAWDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIFTGVISL 200
            ..||:|..|||||||...|..|.:||..::.:|..||.||||||||:||....|:||.|..::||
plant   130 STFVIESRHGFNKQTIWMFIRDMIKGTFLSVILGPPIVAAIIFIVQKGGPYLAIYLWAFMFILSL 194

  Fly   201 VLLTLYPIFIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNAYFYGLWNS 265
            |::|:||:.|||||:|:|||..|.||:.||.||:||||||.|||||:||.||||||||.||.:.:
plant   195 VMMTIYPVLIAPLFNKFTPLPDGDLREKIEKLASSLKFPLKKLFVVDGSTRSSHSNAYMYGFFKN 259

  Fly   266 KRIVLFDTLLLNKGKPDDSELSEEEKGKGCTDE-EVLAVLGHELGHWKLGHVTKNIIIMQVHLFL 329
            |||||:|||:                 :.|.:| |::||:.||||||||.|.|.:.|.:|:..||
plant   260 KRIVLYDTLI-----------------QQCKNEDEIVAVIAHELGHWKLNHTTYSFIAVQILAFL 307

  Fly   330 MFLVFGNVFKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMNFAMTILSRRFEYQADEFA 394
            .|..:..|......:.:.||.  |:|:|:| ||:|.:.:.|...|::|.:.::||.||:|||.||
plant   308 QFGGYTLVRNSTDLFRSFGFD--TQPVLIG-LIIFQHTVIPLQHLVSFGLNLVSRAFEFQADAFA 369

  Fly   395 FKLGFAEQLGQALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRLNRLKELKEEKK 449
            .|||:|:.|..||:||..:||.....|.|||.:::|||.|::||..:.  .|:||
plant   370 VKLGYAKDLRPALVKLQEENLSAMNTDPLYSAYHYSHPPLVERLRAID--GEDKK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	77/190 (41%)
		HtpX	153..440	CDD:223575	137/287 (48%)
		Peptidase_M48	219..439	CDD:279743	102/220 (46%)
ATSTE24	NP_567212.1	M48A_Zmpste24p_like	8..417	CDD:320702	186/436 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	187	1.000	Domainoid score	I974
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	330	1.000	Inparanoid score	I678
OMA	1	1.010	-	-		QHG61664
OrthoDB	1	1.010	-	-		D878143at2759
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		oto2984
orthoMCL	1	0.900	-	-		OOG6_101632
Panther	1	1.100	-	-	LDO	PTHR10120
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3698
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840