DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24a and zmpste24

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001017255.1	Gene:	zmpste24 / 550009	XenbaseID:	XB-GENE-954285	Length:	466	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	223/463 - (48%)
Similarity:	317/463 - (68%)	Gaps:	19/463 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLDADT-VLLSILFLVVIENALEIYISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQ 64
            :|.:..:: :..|:|....|....|.|::.||.|:|:|...|||||.:.|..:||.|:|.|.||:
Frog     5 LSEMSVESQIFYSVLLFSWIVYTWEAYLASRQRKIYRTTTHVPAELGNIMDAETFEKSRLYQLDK 69

  Fly    65 EKFGIFKAVVMDVALLCMELYIGLIAVLWQLSVQVVDKLQWDSKNEIIVSCVFVLISNVLSTFKG 129
            ..|..:..:..: |...:.|.:|.|..||.::.|::.:..:.::.|||.|.||:|::.:.|.|.|
Frog    70 STFSFWSGLYSE-AEGTLILLLGGIPFLWNIAEQMLYRAGFSAEYEIIHSLVFLLLATLFSAFTG 133

  Fly   130 LPFKIYKIFVLEETHGFNKQTARFFAWDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIF 194
            ||:.:|..||:||.||||:||..||..|.:|.|||||.:::|:.:.:::|::.|||.|||:.|:|
Frog   134 LPWSLYNTFVIEERHGFNQQTLGFFFKDAVKKFLVTQCILLPVASLLLYIIKMGGDYFFIYAWLF 198

  Fly   195 TGVISLVLLTLYPIFIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNAYF 259
            |.|:||||:|:|..:|||||||:|||.:|.|::|||::|.|:.|||||::|||||||||||||||
Frog   199 TLVVSLVLVTIYADYIAPLFDKFTPLPEGDLKESIENMAKSIDFPLTKVYVVEGSKRSSHSNAYF 263

  Fly   260 YGLWNSKRIVLFDTLL-----LNKGKPDDSELSEE-----------EKGKGCTDEEVLAVLGHEL 308
            ||.:.:||||||||||     |||...:|:..:|.           .|.:||.::||||||||||
Frog   264 YGFFKNKRIVLFDTLLEDYSPLNKEGTEDTSGNENTELKAKVKQNLNKKQGCNNQEVLAVLGHEL 328

  Fly   309 GHWKLGHVTKNIIIMQVHLFLMFLVFGNVFKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNA 373
            |||||||..|||:|.||:.||.|.:|..:......:.|.||. .|:|.|:||:|:|.::.:|||.
Frog   329 GHWKLGHTVKNIVISQVNSFLCFFLFAVLIGRKELFAAFGFY-NTQPTLIGLMIIFQFIFSPYNE 392

  Fly   374 LMNFAMTILSRRFEYQADEFAFKLGFAEQLGQALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRL 438
            :::|.:|:||||||:|||.||..||.|:.|..||||||.|||||||.||::|.|::|||.||:||
Frog   393 VLSFCLTVLSRRFEFQADAFARNLGKAKDLYSALIKLNKDNLGFPVSDWVFSMWHYSHPPLLERL 457

  Fly   439 NRLKELKE 446
            ..||..|:
Frog   458 QALKVDKQ 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	80/184 (43%)
		HtpX	153..440	CDD:223575	165/302 (55%)
		Peptidase_M48	219..439	CDD:279743	129/235 (55%)
zmpste24	NP_001017255.1	M48A_Zmpste24p_like	16..461	CDD:320702	219/446 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1912
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1655
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D407946at33208
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		oto102592
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1406
SonicParanoid	1	1.000	-	-		X3698
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090